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Autor:
Poul-Erik Kofoed, Anita M. Rønn, Susanne Borum Gjedde, Anja Poulsen, Lars Rombo, Amabelia Rodrigues, Michael Alfrangis
Publikováno v:
Tropical Medicine and International Health. 9:171-177
The antifolate drugs sulphadoxine and pyrimethamine are used for treatment of chloroquine-resistant Plasmodium falciparum in Africa. Resistance to pyrimethamine has been associated with point mutations in the dhfr-gene and resistance to sulphadoxine