Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Michael Ailion"'
Autor:
Boopathi Balasubramaniam, Irini Topalidou, Melissa Kelley, Sarina M. Meadows, Owen Funk, Michael Ailion, David S. Fay
Publikováno v:
Biology Open, Vol 12, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/628406337538470ab35089a2a0e0ce90
Autor:
Kristen Davis, Christo Mitchell, Olivia Weissenfels, Jihong Bai, David M Raizen, Michael Ailion, Irini Topalidou
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010613 (2023)
Animals alter their behavior in manners that depend on environmental conditions as well as their developmental and metabolic states. For example, C. elegans is quiescent during larval molts or during conditions of satiety. By contrast, worms enter an
Externí odkaz:
https://doaj.org/article/0fd979be4cb3468587a6cf18ea2e5410
Autor:
Ye Xu, Lin Zhang, Yan Liu, Irini Topalidou, Cera Hassinan, Michael Ailion, Zhenqiang Zhao, Tan Wang, Zhibin Chen, Jihong Bai
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102247- (2021)
Summary: Animals require robust yet flexible programs to support locomotion. Here we report a pathway that connects the D1-like dopamine receptor DOP-1 with a sleep mechanism to modulate swimming in C. elegans. We show that DOP-1 plays a negative rol
Externí odkaz:
https://doaj.org/article/06d85d8bccd64634b4005a5bd8573cdb
Autor:
Piero Lamelza, Janet M Young, Luke M Noble, Lews Caro, Arielle Isakharov, Meenakshi Palanisamy, Matthew V Rockman, Harmit S Malik, Michael Ailion
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008520 (2019)
Although most unicellular organisms reproduce asexually, most multicellular eukaryotes are obligately sexual. This implies that there are strong barriers that prevent the origin or maintenance of asexuality arising from an obligately sexual ancestor.
Externí odkaz:
https://doaj.org/article/3744df6ec82649c2bda135890a9f6d1c
Autor:
Jill M. Hoyt, Samuel K. Wilson, Madhuri Kasa, Jeremy S. Rise, Irini Topalidou, Michael Ailion
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2979-2989 (2017)
Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling, we performed a forward genetic screen in Caenorhabditis elegans for suppressors of activated
Externí odkaz:
https://doaj.org/article/8f1360937002417e8285e43e49ded1bc
Autor:
Piero Lamelza, Michael Ailion
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 3, Pp 823-834 (2017)
How species arise is a fundamental question in biology. Species can be defined as populations of interbreeding individuals that are reproductively isolated from other such populations. Therefore, understanding how reproductive barriers evolve between
Externí odkaz:
https://doaj.org/article/9edc7bd4b53845e79f27b14dad8c28f0
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200851 (2018)
The lifestyle and feeding habits of nematodes are highly diverse. Several species of Pristionchus (Nematoda: Diplogastridae), including Pristionchus pacificus, have been reported to be necromenic, i.e. to associate with beetles in their dauer diapaus
Externí odkaz:
https://doaj.org/article/3a8e488bfb0d436c8d74a07f48c62473
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007032 (2017)
The NALCN/NCA ion channel is a cation channel related to voltage-gated sodium and calcium channels. NALCN has been reported to be a sodium leak channel with a conserved role in establishing neuronal resting membrane potential, but its precise cellula
Externí odkaz:
https://doaj.org/article/eed701e442804a3d8f973bf895bd1de8
Autor:
Irini Topalidou, Jérôme Cattin-Ortolá, Andrea L Pappas, Kirsten Cooper, Gennifer E Merrihew, Michael J MacCoss, Michael Ailion
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006074 (2016)
The dense-core vesicle is a secretory organelle that mediates the regulated release of peptide hormones, growth factors, and biogenic amines. Dense-core vesicles originate from the trans-Golgi of neurons and neuroendocrine cells, but it is unclear ho
Externí odkaz:
https://doaj.org/article/4cfecc52b4b148878a5dc9cfa819b719
Autor:
Gunther Hollopeter, Jeffrey J Lange, Ying Zhang, Thien N Vu, Mingyu Gu, Michael Ailion, Eric J Lambie, Brian D Slaughter, Jay R Unruh, Laurence Florens, Erik M Jorgensen
Publikováno v:
eLife, Vol 3 (2014)
The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active c
Externí odkaz:
https://doaj.org/article/098d2b93e831478887e9a1475eafe17d