Výsledky vyhledávání - "Michael A. Zschunke"

Use of FFPE-derived DNA in next generation sequencing: DNA extraction methods

Autor: Joshua A. Gorman, Julie M. Cunningham, Zhifu Sun, Karla J. Kopp, Michael A. Zschunke, Aditya Bhagwate, Chen Wang, Samantha J. McDonough

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0211400 (2019)

Archival tissues represent a rich resource for clinical genomic studies, particularly when coupled with comprehensive medical records. Use of these in next generation sequencing (NGS) is a priority. Nine formalin-fixed paraffin-embedded (FFPE) DNA ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b1d4a5280c5792dda3af3b9b1198aa
https://doaj.org/article/e3700947a6464a529167309336d2daa5

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Follicle Luteinization in Hyperandrogenic Follicles of Polycystic Ovary Syndrome Patients Undergoing Gonadotropin Therapy forin VitroFertilization

Autor: Timothy G. Lesnick, Shu C. Foong, David H. Abbott, Daniel A. Dumesic, Jennifer L. Phy, Michael A. Zschunke

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 91:2327-2333

Polycystic ovary syndrome (PCOS) is a reproductive disorder of ovarian hyperandrogenism and insulin resistance characterized by abnormal luteinization of small follicles. After exposure to GnRH analog/FSH stimulation for in vitro fertilization (IVF),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1c7083ca99335246a764ac02be3f2b
https://doi.org/10.1210/jc.2005-2142

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Insulin and Messenger Ribonucleic Acid Expression of Insulin Receptor Isoforms in Ovarian Follicles from Nonhirsute Ovulatory Women and Polycystic Ovary Syndrome Patients

Autor: Timothy G. Lesnick, Ian S. Tummon, Donna R. Session, David H. Abbott, Michael A. Zschunke, Alan R. Thornhill, Jennifer L. Phy, Cheryl A. Conover, David L. Walker, Daniel A. Dumesic

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 89:3561-3566

Insulin action is mediated by two insulin receptor (IR) isoforms, differing in mitogenic and metabolic function. IR isoform expression might occur in human granulosa cells and could be altered in polycystic ovary syndrome (PCOS) from hyperinsulinemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7328dc8af266fe8c6f6f72ee79cdbd
https://doi.org/10.1210/jc.2003-031888

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Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling

Autor: Laurie K. Bale, Patrick C. Roche, Cheryl A. Conover, Oluwole I. Falowo, Michael A. Zschunke, Kimberly R. Kalli

Publikováno v: Endocrinology. 143:3259-3267

The insulin receptor mediates a proliferative response in certain transformed cells, but little is known about its function in ovarian cancer. We used human epithelial ovarian carcinoma cell lines and lifespan-extended normal ovarian surface epitheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db90da0d8630335569a5e117df255c2
https://doi.org/10.1210/en.2001-211408

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Loss of Alternately Spliced Messenger RNA of the Luteinizing Hormone Receptor and Stability of the Follicle-Stimulating Hormone Receptor Messenger RNA in Granulosa Cell Tumors of the Human Ovary

Autor: Michael A. Zschunke, Patrick C. Roche, Monica M. Reinholz

Publikováno v: Gynecologic Oncology. 79:264-271

Objectives. The expression of messenger RNA (mRNA) for the LH (LHR) and FSH receptors (FSHR) was examined in normal human corpora lutea and granulosa cell tumors. Methods. Expression was examined by RT/PCR and DNA sequencing techniques. Results. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5532eb88f254017db06329f325d7ec3
https://doi.org/10.1006/gyno.2000.5946

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Multi-platform analysis of microRNA expression measurements in RNA from fresh frozen and FFPE tissues

Autor: Debra A. Schultz, Peter W. Li, Sumit Middha, Vernadette Simon, Jennifer M. Carr, E. Aubrey Thompson, Christopher P. Kolbert, Fariborz Rakhshan, Eric D. Wieben, Rod M. Feddersen, Wilma L. Lingle, Jin Jen, Jin Sung Jang, Ann L. Oberg, Michael A. Zschunke, Bruce W. Eckloff, György J. Simon, Diane E. Grill, Ping Yang

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e52517 (2013)
PLoS ONE

MicroRNAs play a role in regulating diverse biological processes and have considerable utility as molecular markers for diagnosis and monitoring of human disease. Several technologies are available commercially for measuring microRNA expression. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19afbae44b2cf299cf87db65ca60a47
http://europepmc.org/articles/PMC3561362?pdf=render

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Quantitative miRNA Expression Analysis Using Fluidigm Microfluidics Dynamic Arrays

Autor: Fariborz Rakhshan, Jin Sung Jang, Vernadette Simon, Rod M. Feddersen, Debra A. Schultz, Michael A. Zschunke, Wilma L. Lingle, Jin Jen, Christopher P. Kolbert

Publikováno v: BMC Genomics, Vol 12, Iss 1, p 144 (2011)
BMC Genomics

Background MicroRNAs (miRNAs) represent a growing class of small non-coding RNAs that are important regulators of gene expression in both plants and animals. Studies have shown that miRNAs play a critical role in human cancer and they can influence t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593a39886eab32c04764ef67ef914886
http://www.biomedcentral.com/1471-2164/12/144

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Expression profiling of formalin-fixed paraffin-embedded primary breast tumors using cancer-specific and whole genome gene panels on the DASL® platform

Autor: Jian-Bing Fan, Jin Jen, Beiyun Chen, Jeanette E. Eckel-Passow, Wilma L. Lingle, S. Keith Anderson, Edith A. Perez, Craig April, Julie M. Cunningham, Michael A. Zschunke, Eliza Wickham-Garcia, Monica M. Reinholz, Robert B. Jenkins, Amylou C. Dueck, Ann E. McCullough, Yan W. Asmann, Ann L. Oberg

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 3, Iss 1, p 60 (2010)

Background The cDNA-mediated Annealing, extension, Selection and Ligation (DASL) assay has become a suitable gene expression profiling system for degraded RNA from paraffin-embedded tissue. We examined assay characteristics and the performance of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2fa4bb5baa4f1f94ee0d3cf121eb6e
https://pubmed.ncbi.nlm.nih.gov/21172013

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Specific expression of proteins and phosphoproteins in 3T3 T mesenchymal stem cells at distinct growth arrest and differentiation states

Autor: E. I. Seibel-Ross, R. Sparks, Michael A. Zschunke, Robert E. Scott, Bryan J. Hoerl, Bruce M. Boman, R. Tracy, J. G. Zalitis

Publikováno v: Cell Proliferation. 23:71-87

Murine mesenchymal stem cells can be induced to arrest their growth at a series of growth and differentiation states in the G1 phase of the cell cycle. These include the predifferentiation arrest state (GD) at which the integrated control of prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481b9a8eaa91b34f2ee8c319fe00dc84
https://doi.org/10.1111/j.1365-2184.1990.tb01334.x

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