Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease

Autor: Li Zhang, Zhaohong Qin, Fariba Sharmin, Wei Lin, Konrad M. Ricke, Michael A. Zasloff, Alexandre F.R. Stewart, Hsiao-Huei Chen

Publikováno v: Neurobiology of Disease, Vol 156, Iss , Pp 105402- (2021)

Mutations in the beta-amyloid protein (APP) cause familial Alzheimer's disease. In hAPP-J20 mice expressing mutant APP, pharmacological inhibition or genetic ablation of the tyrosine phosphatase PTP1B prevents CA3 hippocampus neuron loss and cognitiv

Externí odkaz: https://doaj.org/article/0b629ecbb20143d9a03613b3b953c722

Activation of the Bile Acid Pathway and No Observed Antimicrobial Peptide Sequences in the Skin of a Poison Frog

Autor: Megan L. Civitello, Robert Denton, Michael A. Zasloff, John H. Malone

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 581-589 (2019)

The skin secretions of many frogs have genetically-encoded, endogenous antimicrobial peptides (AMPs). Other species, especially aposematic poison frogs, secrete exogenously derived alkaloids that serve as potent defense molecules. The origins of thes

Externí odkaz: https://doaj.org/article/4b77055247fc49bcbada538255a11452

Contributors

Autor: Darryl J. Adamko, N. Franklin Adkinson, Cezmi A. Akdis, Yassine Amrani, Andrea J. Apter, Erika Avila-Tang, Claus Bachert, Katherine J. Baines, Mark Ballow, Jennifer L. Bankers-Fulbright, Peter J. Barnes, Neal P. Barney, Leah Bellehsen, Bruce G. Bender, Paul J. Bertics, Eugene R. Bleecker, Bruce S. Bochner, Mark Boguniewicz, Larry Borish, Louis-Philippe Boulet, Jean Bousquet, Joshua A. Boyce, David H. Broide, Rebecca H. Buckley, A. Wesley Burks, Robert K. Bush, Paula J. Busse, William W. Busse, William J. Calhoun, Carlos A. Camargo, Brendan J. Canning, Thomas B. Casale, Gülfem Elif Çelik, Christina D. Chambers, Moira Chan-Yeung, Javier Chinen, Donald W. Cockcroft, Lauren Cohn, Ellen B. Cook, Jonathan Corren, Ronina Covar, Adnan Custovic, Timothy DeCapite, Pascal Demoly, Anne E. Dixon, Myrna B. Dolovich, Stephen R. Durham, Ronald Eccles, Alan M. Edwards, Robert E. Esch, John V. Fahy, Reuben Falkoff, Thomas A. Fleisher, Susan C. Foley, Michael M. Frank, Allison D. Fryer, Anthony A. Gaspari, Philippe Gevaert, Peter G. Gibson, Michael D. Gober, David B.K. Golden, Frank M. Graziano, Theresa Guilbert, Sudhir Gupta, Qutayba Hamid, Robert G. Hamilton, Hamida Hammad, C. Garren Hester, Stephen T. Holgate, Florence Ida Hsu, Charles G. Irvin, Elliot Israel, David B. Jacoby, Peter K. Jeffery, Christine Cole Johnson, Richard B. Johnston, Sujani Kakumanu, Allen P. Kaplan, Arthur Kavanaugh, Pramod Kelkar, H. William Kelly, John M. Kelso, Hirohito Kita, Cynthia J. Koziol, Paige Lacy, Bart N. Lambrecht, Robert F. Lemanske, Donald Y.M. Leung, Francesca Levi-Schaffer, Ian P. Lewkowich, James T. Li, Phillip L. Lieberman, Andrew H. Liu, Richard F. Lockey, Andrew D. Luster, Donald W. Macglashan, Eric Macy, Jean-Luc Malo, Elizabeth Matsui, E.R. McFadden, Michael H. Mellon, Dean D. Metcalfe, Deborah A. Meyers, Zamaneh Mikhak, Redwan Moqbel, Mark H. Moss, Hedwig S. Murphy, Arnon Nagler, Harold S. Nelson, Ewa Niżankowska-Mogilnicka, Paul M. O'Byrne, Solomon O. (Wole) Odemuyiwa, Nara T. Orban, Dennis R. Ownby, Reynold A. Panettieri, Mary E. Paul, David B. Peden, R. Stokes Peebles, Werner J. Pichler, Mark R. Pittelkow, Douglas A. Plager, Thomas A.E. Platts-Mills, David Proud, Hengameh Heidarian Raissy, Cynthia S. Rand, Anuradha Ray, Charles E. Reed, Clive Robinson, Antonino Romano, Lanny J. Rosenwasser, Marc E. Rothenberg, Brian H. Rowe, Michael C. Saavedra, Alireza Sadeghnejad, Hesham Saleh, Jonathan M. Samet, Hugh A. Sampson, Marek Sanak, Michael Schatz, R. Robert Schellenberg, Robert P. Schleimer, John T. Schroeder, Chun Y. Seow, William T. Shearer, James H. Shelhamer, Hans-Uwe Simon, F Estelle R. Simons, Jodie L. Simpson, Jay E. Slater, Philip H. Smith, Michael C. Sneller, Christine A. Sorkness, Joseph D. Spahn, P. Sriramarao, James L. Stahl, Geoffrey A. Stewart, Jeffrey R. Stokes, Kathleen E. Sullivan, Andrzej Szczeklik, Stanley J. Szefler, Stephen L. Taylor, Abba I. Terr, Shibu Thomas, Omar Tliba, Alkis Togias, Bradley J. Undem, Paul van Cauwenberge, James Varani, Donata Vercelli, Stephan Von Gunten, Martin Wagenmann, Ulrich Wahn, Peter A. Ward, Michael E. Wechsler, Catherine R. Weiler, David Weldon, Peter F. Weller, Sally E. Wenzel, Gregory J. Wiepz, Denise G. Wiesch, Marsha Wills-Karp, Robert A. Wood, Leman Yel, John W. Yunginger, Michael A. Zasloff, Robert S. Zeiger, Jihui Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ae37e8ed3a5f4936f69731e04928b9e
https://doi.org/10.1016/b978-0-323-05659-5.00100-5

843 AMNIOTIC MEMBRANE IMPLANTATION IN MUCOPOLYSACCHARIDOSIS

Autor: Harold D McDonald, George Constantopoulos, Anita Plkus, Muriel I Kaiser-Rupfer, Rafael C Caruso, Joseph Muenzer, Elizabeth F. Neufeld, James B Sidbury, Michael A Zasloff

Publikováno v: Pediatric Research. 19:251A-251A

Amniotic membrane implantation has been performed as an approach to enzyme replacement in mucopolysaccharidosis (MPS). The rationale for this study is based on the findings that cultured amniocytes secrete lysosomal enzymes and that amnion membranes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee36d9920b2f3feafdee5ff839a29dab
https://doi.org/10.1203/00006450-198504000-00873