Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael A. Weinreich"'
Autor:
Silvio Danese, Séverine Vermeire, Wen Zhou, Aileen L Pangan, Jesse Siffledeen, Susan Greenbloom, Xavier Hébuterne, Geert D'Haens, Hiroshi Nakase, Julian Panés, Peter D R Higgins, Pascal Juillerat, James O Lindsay, Edward V Loftus, William J Sandborn, Walter Reinisch, Min-Hu Chen, Yuri Sanchez Gonzalez, Bidan Huang, Wangang Xie, John Liu, Michael A Weinreich, Remo Panaccione
Publikováno v:
The Lancet, 399(10341), 2113-2128. Elsevier Limited
BACKGROUND There is a great unmet need for advanced therapies that provide rapid, robust, and sustained disease control for patients with ulcerative colitis. We assessed the efficacy and safety of upadacitinib, an oral selective Janus kinase 1 inhibi
Autor:
Miguel A, Alvarez Villela, Ahmad, Alkhalil, Michael A, Weinreich, Jonathan, Koslowsky, Shunsuke, Aoi, M Azeem, Latib
Publikováno v:
Tex Heart Inst J
Atypical presentations of ST-segment-elevation myocardial infarction (STEMI) have been reported in patients who have COVID-19. We have seen this occurrence in our center in Bronx, New York, where multitudes of patients sought treatment for the corona
Autor:
Hana Alachkar, Kathleen E. Sullivan, Claire Bethune, Erica Brittain, Niall Conlon, Neil Romberg, Claire Langley, Shanmuganathan Chandrakasan, Daniel Veltri, Matthew C. Cook, Bahar Miraghazadeh, Kelly D. Stone, Stefanie Frey-Jakobs, Jeffrey I. Cohen, Andrew L. Snow, Sinisa Savic, Sophie Hambleton, Maria Cecilia Poli, Arturo Borzutzky, Alexandra F. Freeman, Jeffrey R. Stinson, Michael B. Jordan, Michael A. Weinreich, T. Prescott Atkinson, Troy R. Torgerson, Michele P. Lambert, Alejandro A. Schäffer, T. Ronan Leahy, Celeste G Nelson, Peter D. Arkwright, Ivan K. Chinn, Stephan Weidinger, Laura Lucas, Tracy A Briggs, Martha Nason, Kenneth Paris, Smita Y. Patel, Sandhya Limaye, Sebastian Fuchs, Julia M. Hartberger, Bodo Grimbacher, Batsukh Dorjbal, Stephan Ehl, Amy Theos, Sergey Nejentsev, Andrew F. Whyte, Lena Moebus, Andrew J. Oler, Thomas DiMaggio, Joie Davis, Andre Franke, Chi Ma, Joshua D. Milner, Alla Bulashevska, Jeffrey D. Lebensburger
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:1482-1495
Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold protein in lymphocytes that links antigen receptor engagement with downstream signaling to nuclear factor κB, c-Jun N-terminal kinase, and mechanistic target of rapa
Autor:
Michael A. Weinreich, Megan A. Cooper, Pia J. Hauk, Thomas DiMaggio, Batsukh Dorjbal, Geronimo Dubra, Eric Meffre, Brian S. Kim, Jonathan J. Lyons, Jordan K. Abbott, Erwin W. Gelfand, Chi Ma, Emma Prieto, Kelly D. Stone, Joshua D. Milner, Natsuko Yamakawa, Jeffrey R. Stinson, Silvia Danielian, Jonathan Zaiat, Paul R. Reynolds, Andrew L. Snow, Swadhinya Arjunaraja, Yu Zhang, Elisa Ruffo, Salomé Glauzy, Sergio D. Rosenzweig, Jennifer Stoddard, Marcelo A. Martí, Matías Oleastro, Nina Jones, Neil Romberg, Alejandro Palma, Kelsey Voss, Celeste G Nelson, Joshua J McElwee, Julie E. Niemela, Helen F. Matthews, Yuan Zhang, Andrea Bernasconi
Publikováno v:
Nature Genetics. 49:1192-1201
Few monogenic causes for severe manifestations of common allergic diseases have been identified. Through next-generation sequencing on a cohort of patients with severe atopic dermatitis with and without comorbid infections, we found eight individuals
Publikováno v:
Frontiers in Pediatrics
The number of identified monogenic causes of childhood-onset autoimmunity due to nodal and extranodal lymphoproliferation has increased. These pathogenic genetic variants provide the potential for pathway-specific treatment. Novel variants also requi
Autor:
Andrew J. Oler, Michael A. Weinreich, Mukil Natarajan, Tirdad T. Zangeneh, Michail S. Lionakis, Amy P. Hsu, Tara F. Carr, Janyce A. Sugui, Joshua D. Milner, Morgan Similuk, Kyung J. Kwon-Chung
Publikováno v:
Open Forum Infectious Diseases
Background Signal transducer and activator of transcription 3 (STAT3) loss-of-function mutations in humans result in Job’s syndrome, characterized by elevated IgE, bacterial infections, chronic mucocutaneous candidiasis, pulmonary aspergillosis due
Autor:
Michail S. Lionakis, Julie E. Niemela, Amy P. Hsu, Yuan Zhang, Kyung J. Kwon-Chung, Alexandra F. Freeman, Andrew J. Oler, Mukil Natarajan, Amanda L. Collar, Janyce A. Sugui, Joshua D. Milner, John A. Butman, Steven M. Holland, Jean K. Lim, Tirdad T. Zangeneh, Morgan Similuk, Tara F. Carr, Jigar V. Desai, Stefania Pittaluga, Lindsey B. Rosen, Michael A. Weinreich
Publikováno v:
Journal of Allergy and Clinical Immunology. 142:993-997.e3
Publikováno v:
Nature Immunology. 11:709-716
Several gene-deficiency models promote the development of innate CD8(+) T cells that have diverse T cell antigen receptors (TCRs) but have a memory phenotype and rapidly produce cytokines. We demonstrate here that similar cells developed in mice defi
Publikováno v:
The Journal of Immunology. 184:6060-6066
gammadelta T cells are generated in the thymus and traffic to secondary lymphoid organs and epithelial surfaces, where they regulate immune responses. alphabeta T cells require sphingosine 1-phosphate receptor type 1 (S1P(1)) and CD62L for thymic emi
Autor:
Kelly D. Stone, Neil Romberg, Andrew L. Snow, Megan A. Cooper, Matías Oleastro, Swadhinya Arjunaraja, Nina Jones, Emma Prieto, Kelsey Voss, Silvia Danielian, Natsuko Yamakawa, Yu Zhang, Jonathan Zaiat, Julie E. Niemela, Brian S. Kim, Batsukh Dorjbal, Sergio D. Rosenzweig, Helen F. Matthews, Erwin W. Gelfand, Chi Ma, Jeffrey R. Stinson, Joshua D. Milner, Jennifer Stoddard, Geronimo Dubra, Paul R. Reynolds, Elisa Ruffo, Joshua McElwee, Michael A. Weinreich, Alejandro Palma, Eric Meffre, Jonathan J. Lyons, Celeste G Nelson, Pia J. Hauk, Jordan K. Abbott, Yuan Zhang, Andrea Bernasconi, Salomé Glauzy, Thomas DiMaggio, Marcelo A. Martí
Publikováno v:
Nature genetics
Few monogenic causes for severe manifestations of common allergic diseases have been identified. Via next generation sequencing on a cohort of patients with severe atopic dermatitis, some with comorbid infections, we found 8 individuals from 4 famili