Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael A. Weinreich"'
Autor:
Silvio Danese, Séverine Vermeire, Wen Zhou, Aileen L Pangan, Jesse Siffledeen, Susan Greenbloom, Xavier Hébuterne, Geert D'Haens, Hiroshi Nakase, Julian Panés, Peter D R Higgins, Pascal Juillerat, James O Lindsay, Edward V Loftus, William J Sandborn, Walter Reinisch, Min-Hu Chen, Yuri Sanchez Gonzalez, Bidan Huang, Wangang Xie, John Liu, Michael A Weinreich, Remo Panaccione
Publikováno v:
The Lancet, 399(10341), 2113-2128. Elsevier Limited
BACKGROUND There is a great unmet need for advanced therapies that provide rapid, robust, and sustained disease control for patients with ulcerative colitis. We assessed the efficacy and safety of upadacitinib, an oral selective Janus kinase 1 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33600bd654cc9215cd8503b388ec5ccd
https://doi.org/10.1016/s0140-6736(22)00581-5
https://doi.org/10.1016/s0140-6736(22)00581-5
Autor:
Miguel A, Alvarez Villela, Ahmad, Alkhalil, Michael A, Weinreich, Jonathan, Koslowsky, Shunsuke, Aoi, M Azeem, Latib
Publikováno v:
Tex Heart Inst J
Atypical presentations of ST-segment-elevation myocardial infarction (STEMI) have been reported in patients who have COVID-19. We have seen this occurrence in our center in Bronx, New York, where multitudes of patients sought treatment for the corona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c35938485ae1d2aabb45765e4e9515
https://doi.org/10.14503/thij-20-7446
https://doi.org/10.14503/thij-20-7446
Autor:
Hana Alachkar, Kathleen E. Sullivan, Claire Bethune, Erica Brittain, Niall Conlon, Neil Romberg, Claire Langley, Shanmuganathan Chandrakasan, Daniel Veltri, Matthew C. Cook, Bahar Miraghazadeh, Kelly D. Stone, Stefanie Frey-Jakobs, Jeffrey I. Cohen, Andrew L. Snow, Sinisa Savic, Sophie Hambleton, Maria Cecilia Poli, Arturo Borzutzky, Alexandra F. Freeman, Jeffrey R. Stinson, Michael B. Jordan, Michael A. Weinreich, T. Prescott Atkinson, Troy R. Torgerson, Michele P. Lambert, Alejandro A. Schäffer, T. Ronan Leahy, Celeste G Nelson, Peter D. Arkwright, Ivan K. Chinn, Stephan Weidinger, Laura Lucas, Tracy A Briggs, Martha Nason, Kenneth Paris, Smita Y. Patel, Sandhya Limaye, Sebastian Fuchs, Julia M. Hartberger, Bodo Grimbacher, Batsukh Dorjbal, Stephan Ehl, Amy Theos, Sergey Nejentsev, Andrew F. Whyte, Lena Moebus, Andrew J. Oler, Thomas DiMaggio, Joie Davis, Andre Franke, Chi Ma, Joshua D. Milner, Alla Bulashevska, Jeffrey D. Lebensburger
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:1482-1495
Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold protein in lymphocytes that links antigen receptor engagement with downstream signaling to nuclear factor κB, c-Jun N-terminal kinase, and mechanistic target of rapa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f399f0a51375745fd3767ab21c69a8a4
https://doi.org/10.1016/j.jaci.2018.08.013
https://doi.org/10.1016/j.jaci.2018.08.013
Autor:
Michael A. Weinreich, Megan A. Cooper, Pia J. Hauk, Thomas DiMaggio, Batsukh Dorjbal, Geronimo Dubra, Eric Meffre, Brian S. Kim, Jonathan J. Lyons, Jordan K. Abbott, Erwin W. Gelfand, Chi Ma, Emma Prieto, Kelly D. Stone, Joshua D. Milner, Natsuko Yamakawa, Jeffrey R. Stinson, Silvia Danielian, Jonathan Zaiat, Paul R. Reynolds, Andrew L. Snow, Swadhinya Arjunaraja, Yu Zhang, Elisa Ruffo, Salomé Glauzy, Sergio D. Rosenzweig, Jennifer Stoddard, Marcelo A. Martí, Matías Oleastro, Nina Jones, Neil Romberg, Alejandro Palma, Kelsey Voss, Celeste G Nelson, Joshua J McElwee, Julie E. Niemela, Helen F. Matthews, Yuan Zhang, Andrea Bernasconi
Publikováno v:
Nature Genetics. 49:1192-1201
Few monogenic causes for severe manifestations of common allergic diseases have been identified. Through next-generation sequencing on a cohort of patients with severe atopic dermatitis with and without comorbid infections, we found eight individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0771c386e540f21e44863d09e0748ebd
https://doi.org/10.1038/ng.3898
https://doi.org/10.1038/ng.3898
Publikováno v:
Frontiers in Pediatrics
The number of identified monogenic causes of childhood-onset autoimmunity due to nodal and extranodal lymphoproliferation has increased. These pathogenic genetic variants provide the potential for pathway-specific treatment. Novel variants also requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca99a66553c3267e5b80e2e7be33ffcc
http://europepmc.org/articles/PMC5347118
http://europepmc.org/articles/PMC5347118
Autor:
Andrew J. Oler, Michael A. Weinreich, Mukil Natarajan, Tirdad T. Zangeneh, Michail S. Lionakis, Amy P. Hsu, Tara F. Carr, Janyce A. Sugui, Joshua D. Milner, Morgan Similuk, Kyung J. Kwon-Chung
Publikováno v:
Open Forum Infectious Diseases
Background Signal transducer and activator of transcription 3 (STAT3) loss-of-function mutations in humans result in Job’s syndrome, characterized by elevated IgE, bacterial infections, chronic mucocutaneous candidiasis, pulmonary aspergillosis due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120eb47e464c1982984a6dae7bcf1f7d
http://europepmc.org/articles/PMC5631805
http://europepmc.org/articles/PMC5631805
Autor:
Michail S. Lionakis, Julie E. Niemela, Amy P. Hsu, Yuan Zhang, Kyung J. Kwon-Chung, Alexandra F. Freeman, Andrew J. Oler, Mukil Natarajan, Amanda L. Collar, Janyce A. Sugui, Joshua D. Milner, John A. Butman, Steven M. Holland, Jean K. Lim, Tirdad T. Zangeneh, Morgan Similuk, Tara F. Carr, Jigar V. Desai, Stefania Pittaluga, Lindsey B. Rosen, Michael A. Weinreich
Publikováno v:
Journal of Allergy and Clinical Immunology. 142:993-997.e3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::498b8ec12b873aa1ad916695c1a864b5
https://doi.org/10.1016/j.jaci.2018.05.009
https://doi.org/10.1016/j.jaci.2018.05.009
Publikováno v:
Nature Immunology. 11:709-716
Several gene-deficiency models promote the development of innate CD8(+) T cells that have diverse T cell antigen receptors (TCRs) but have a memory phenotype and rapidly produce cytokines. We demonstrate here that similar cells developed in mice defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144c547a79bdffeff755876c43ecff4c
https://doi.org/10.1038/ni.1898
https://doi.org/10.1038/ni.1898
Publikováno v:
The Journal of Immunology. 184:6060-6066
gammadelta T cells are generated in the thymus and traffic to secondary lymphoid organs and epithelial surfaces, where they regulate immune responses. alphabeta T cells require sphingosine 1-phosphate receptor type 1 (S1P(1)) and CD62L for thymic emi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7eff69cfa3d819b44ead210f798aea9
https://doi.org/10.4049/jimmunol.1000511
https://doi.org/10.4049/jimmunol.1000511
Publikováno v:
The Journal of Immunology. 181:2265-2270
The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 α/β T cells, γ/δ T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d3868652789067f0b6c05ef1f4e23d
https://doi.org/10.4049/jimmunol.181.4.2265
https://doi.org/10.4049/jimmunol.181.4.2265