Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Michael A. Walters"'
Autor:
Jayme L. Dahlin, Bruce K. Hua, Beth E. Zucconi, Shawn D. Nelson, Shantanu Singh, Anne E. Carpenter, Jonathan H. Shrimp, Evelyne Lima-Fernandes, Mathias J. Wawer, Lawrence P. W. Chung, Ayushi Agrawal, Mary O’Reilly, Dalia Barsyte-Lovejoy, Magdalena Szewczyk, Fengling Li, Parnian Lak, Matthew Cuellar, Philip A. Cole, Jordan L. Meier, Tim Thomas, Jonathan B. Baell, Peter J. Brown, Michael A. Walters, Paul A. Clemons, Stuart L. Schreiber, Bridget K. Wagner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with
Externí odkaz:
https://doaj.org/article/a0652f03d5554808827f7867140b6ae5
Autor:
Judit M. Pérez Ortiz, Nissa Mollema, Nicholas Toker, Carolyn J. Adamski, Brennon O'Callaghan, Lisa Duvick, Jillian Friedrich, Michael A. Walters, Jessica Strasser, Jon E. Hawkinson, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr, Sarita Lagalwar
Publikováno v:
Neurobiology of Disease, Vol 116, Iss , Pp 93-105 (2018)
Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATX
Externí odkaz:
https://doaj.org/article/b9f62c15636b4d38bc9157a6c5c1ed0f
Autor:
Jayme L. Dahlin, Kathryn M. Nelson, Jessica M. Strasser, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, Jordan L. Meier, Cheryl H. Arrowsmith, Peter J. Brown, Jonathan B. Baell, Michael A. Walters
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority ar
Externí odkaz:
https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30
Publikováno v:
ARKIVOC, Vol 2002, Iss 8, Pp 91-111 (2002)
Externí odkaz:
https://doaj.org/article/c4c44300e6fc4f7b9deb62117ce2ebe0
Autor:
Noah Nathan Kochen, Vivek Vasandani, Darren Seaney, Anil K. Pandey, Michael A. Walters, Anthony R. Braun, Jonathan N. Sachs
Publikováno v:
ACS Chemical Neuroscience. 13:2646-2657
Recent high-resolution structures of alpha-synuclein (aSyn) fibrils offer promise for rational approaches to drug discovery for Parkinson's disease and Lewy body dementia. Harnessing the first such structures, we previously used molecular dynamics an
Autor:
Gurpreet Singh, Peng Liu, Katherine R. Yao, Jessica M. Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J. Teravskis, Jessica M. Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M. Nelson, Dezhi Liao, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
ACS Chem Neurosci
Synaptic and cognitive deficits mediated by a severe reduction in excitatory neurotransmission caused by a disproportionate accumulation of the neuronal protein tau in dendritic spines is a fundamental mechanism that has been found repeatedly in mode
Autor:
Nina T Lichtenberg, Brian Lee, Vadim Kashtelyan, Bharadwaja S Chappa, Henok T Girma, Elizabeth A Green, Shir Kantor, Dave A Lagowala, Matthew A Myers, Danielle Potemri, Meredith G Pecukonis, Robel T Tesfay, Michael S Walters, Adam C Zhao, R James R Blair, Joseph F Cheer, Matthew R Roesch
Publikováno v:
eLife, Vol 7 (2018)
Rats exhibit ‘empathy’ making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation
Externí odkaz:
https://doaj.org/article/f0b709ee5e17444f8ce2d47440c8dea6
Autor:
Liewei Wang, Richard M. Weinshilboum, Scott H. Kaufmann, Cristina Correia, Michael A. Walters, Matthew E. Cuellar, Barbara Goodnature, Matthew P. Goetz, Tufia Haddad, Erin E. Carlson, Poulami Barman, Bernhard Volz, Bingshu E. Chen, Paul E. Goss, Matthew J. Ellis, Krishna R. Kalari, Zeruesenay Desta, Ravinder J. Singh, Tanya L. Hoskin, Peter A. Fasching, Lois E. Shepherd, Vera J. Suman, Junmei Cairns, James N. Ingle
Purpose:To determine if the degree of estrogen suppression with aromatase inhibitors (AI: anastrozole, exemestane, letrozole) is associated with efficacy in early-stage breast cancer, and to examine for differences in the mechanism of action between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863cc18ace5c45681a8e51a753a51ac2
https://doi.org/10.1158/1078-0432.c.6530129.v1
https://doi.org/10.1158/1078-0432.c.6530129.v1
Autor:
Liewei Wang, Richard M. Weinshilboum, Scott H. Kaufmann, Cristina Correia, Michael A. Walters, Matthew E. Cuellar, Barbara Goodnature, Matthew P. Goetz, Tufia Haddad, Erin E. Carlson, Poulami Barman, Bernhard Volz, Bingshu E. Chen, Paul E. Goss, Matthew J. Ellis, Krishna R. Kalari, Zeruesenay Desta, Ravinder J. Singh, Tanya L. Hoskin, Peter A. Fasching, Lois E. Shepherd, Vera J. Suman, Junmei Cairns, James N. Ingle
This file is the revised clean Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628f1d65cb215164fa22d2124af0f093
https://doi.org/10.1158/1078-0432.22479095
https://doi.org/10.1158/1078-0432.22479095
Autor:
Michael S. Walters, David C. Wong
The Community Multiscale Air Quality Model (CMAQ) has been a vital tool for air quality research and management at the United States Environmental Protection Agency (U.S. EPA), and at government environmental agencies and academic institutions worldw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9881a2065389165314ba0d405980a764
https://gmd.copernicus.org/articles/16/1179/2023/
https://gmd.copernicus.org/articles/16/1179/2023/