Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Michael A. Vincent"'
Autor:
Spencer I. Danto, Nikolaos Tsamandouras, Padma Reddy, Steven A. Gilbert, Jessica Y. Mancuso, Karen Page, Jean S. Beebe, Elena Peeva, Michael S. Vincent
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-8 (2024)
Abstract PF-06817024 is a humanized antibody against interleukin-33 that has the potential to inhibit type 2 inflammation. An exploratory analysis of the pharmacodynamics and clinical effects of single and repeat doses of PF-06817024 was assessed in
Externí odkaz:
https://doaj.org/article/342daf6733c54dea9222dbbb5a9d74c3
Autor:
Rachel (Rae) J. House, Molly T. Soper-Hopper, Michael P. Vincent, Abigail E. Ellis, Colt D. Capan, Zachary B. Madaj, Emily Wolfrum, Christine N. Isaguirre, Carlos D. Castello, Amy B. Johnson, Martha L. Escobar Galvis, Kelsey S. Williams, Hyoungjoo Lee, Ryan D. Sheldon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar metabolomics, we discover a
Externí odkaz:
https://doaj.org/article/3c2a5db689674347bf92e9f80980aebe
Autor:
Stanley Cohen, Jean S. Beebe, Vishala Chindalore, Shunjie Guan, Mina Hassan-Zahraee, Madhurima Saxena, Li Xi, Craig Hyde, Sarita Koride, Robert Levin, Shannon Lubaczewski, Mikhail Salganik, Abigail Sloan, Erin Stevens, Elena Peeva, Michael S. Vincent, David A. Martin, Myron Chu
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Background The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 (CXCR5
Externí odkaz:
https://doaj.org/article/de4e6e08230342d8a8ccd262c81c4143
Akademický článek
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Autor:
Brett King, Emma Guttman-Yassky, Elena Peeva, Anindita Banerjee, Linda Zhu, Hua Zhu, Lori Ann Cox, Michael S. Vincent, Rodney Sinclair
Publikováno v:
JID Innovations, Vol 2, Iss 6, Pp 100156- (2022)
The 24-week, double-blind period of the ALLEGRO phase 2a trial (NCT02974868) evaluated the safety and efficacy of ritlecitinib (Jak3/tyrosine kinase expressed in the hepatocellular carcinoma inhibitor) and brepocitinib (tyrosine kinase 2/Jak1 inhibit
Externí odkaz:
https://doaj.org/article/0116e2d715b245428d9d62d101f6f5d4
Autor:
Sijia Yi, Sun-Young Kim, Michael P. Vincent, Simseok A. Yuk, Sharan Bobbala, Fanfan Du, Evan Alexander Scott
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104555- (2022)
Summary: Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including “all-in-one” CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficien
Externí odkaz:
https://doaj.org/article/d432c22450994663a654c2b64e717126
Autor:
Ravi Shankar P. Singh, Vivek Pradhan, Erika S. Roberts, Matthew Scaramozza, Elizabeth Kieras, Jeremy D. Gale, Elena Peeva, Michael S. Vincent, Anindita Banerjee, Andrew Fensome, Martin E. Dowty, Peter Winkle, Christopher Tehlirian
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 671-682 (2021)
Selective inhibition of tyrosine kinase 2 (TYK2) may offer therapeutic promise in inflammatory conditions, with its role in downstream pro‐inflammatory cytokine signaling. In this first‐in‐human study, we evaluated the safety, tolerability, and
Externí odkaz:
https://doaj.org/article/b2ae82b7680a48168cc227d391573f2e
Autor:
Michael P. Vincent, Sharan Bobbala, Nicholas B. Karabin, Molly Frey, Yugang Liu, Justin O. Navidzadeh, Trevor Stack, Evan A. Scott
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Polymeric nanocarriers used for drug delivery are often coated by albumin in vivo influencing the therapeutic outcomes. Here, the authors engineer the surface chemistry of a nanocarrier to either stabilize or denature the structure of adsorbed albumi
Externí odkaz:
https://doaj.org/article/15a179777f9c4b2e8d6492098d24f2b1
Autor:
Fanfan Du, Baofu Qiao, Trung Dac Nguyen, Michael P. Vincent, Sharan Bobbala, Sijia Yi, Chamille Lescott, Vinayak P. Dravid, Monica Olvera de la Cruz, Evan Alexander Scott
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Natural biomolecules such as peptides and DNA can dynamically self-organize into diverse hierarchical structures. Here the authors report experiments and simulations on the dynamic network self-assembly and subsequent collapse of the synthetic homopo
Externí odkaz:
https://doaj.org/article/64ac7fd9f98a4752983d43cca3a4d5d0
Publikováno v:
Advanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
Self‐assembling filomicelles (FMs) are of great interest to nanomedicine due to their structural flexibility, extensive systemic circulation time, and amenability to unique “cylinder‐to‐sphere” morphological transitions. However, current fa
Externí odkaz:
https://doaj.org/article/bbefe2efe0ec45d4a38159a6dfc54171