Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Michael A. Tones"'
Autor:
Jonathan J Cherry, Christine J DiDonato, Elliot J Androphy, Alessandro Calo, Kyle Potter, Sara K Custer, Sarah Du, Timothy L Foley, Ariamala Gopalsamy, Emily J Reedich, Susana M Gordo, William Gordon, Natalie Hosea, Lyn H Jones, Daniel K Krizay, Gregory LaRosa, Hongxia Li, Sachin Mathur, Carol A Menard, Paraj Patel, Rebeca Ramos-Zayas, Anne Rietz, Haojing Rong, Baohong Zhang, Michael A Tones
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185079 (2017)
C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) prote
Externí odkaz:
https://doaj.org/article/d509895517b840fca86c06c702f957d6
Autor:
Sandy M. Chu, Matthew Dukinfield, Michael E. J. Preedy, Adrian J. Hobbs, Reshma S. Baliga, Amie J Moyes, Michael A. Tones, Aisah A. Aubdool, Kristen J. Bubb
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The morbidity and mortality associated with heart failure (HF) are unacceptably high. Cyclic guanosine-3′,5′-monophosphate (cGMP) plays a key role in preserving cardiac structure and function, and therapeutically targeting cGMP in HF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5dec43405d21bbd24785eae9bc4596
https://doi.org/10.1073/pnas.1800996115
https://doi.org/10.1073/pnas.1800996115
Autor:
Shenping Liu, Lee R. Roberts, Erik C. Hett, Mihir D. Parikh, Ariamala Gopalsamy, Kieran F. Geoghegan, Ralph P. Robinson, Michael A. Tones, Lyn H. Jones, Robert E. Kyne, Hua Xu, Carol A. Menard, Arjun Narayanan
Publikováno v:
ACS Chemical Biology. 10:1094-1098
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes. Specific tyrosine residues in the active site of the mRNA-decapping scavenger enzyme DcpS were modified using reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ccf8d774527c711c78291b05503aba
https://doi.org/10.1021/cb5009475
https://doi.org/10.1021/cb5009475
Autor:
Sachin Mathur, Jonathan J. Cherry, Baohong Zhang, Christine J. DiDonato, Rebeca Ramos-Zayas, Kyle Potter, Gregory LaRosa, Michael A. Tones, Haojing Rong, Natalie Hosea, Alessandro Calo, Timothy L. Foley, Sarah Du, William Gordon, Carol A. Menard, Paraj Patel, Susana Gordo, Elliot J. Androphy, Anne Rietz, Lyn H. Jones, Sara K. Custer, Daniel K. Krizay, Emily J. Reedich, Ariamala Gopalsamy, Hongxia Li
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185079 (2017)
PLoS ONE
PLoS ONE
C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a8004254f0368601d90fc794482243
http://europepmc.org/articles/PMC5612656?pdf=render
http://europepmc.org/articles/PMC5612656?pdf=render
Autor:
Bruce L. Homer, Catharine J. Andresen, Daniel Morton, James A. Warneke, Dale L. Morris, Cedo M. Bagi, Michael A. Tones, Laurence O. Whiteley
Publikováno v:
Toxicologic Pathology. 43:411-423
Orally administered small molecule agonists of soluble guanylate cyclase (sGC) induced increased numbers of osteoclasts, multifocal bone resorption, increased porosity, and new bone formation in the appendicular and axial skeleton of Sprague-Dawley r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564b97e00d4be26323006d8bd252c650
https://doi.org/10.1177/0192623314546559
https://doi.org/10.1177/0192623314546559
Autor:
Michael A. Tones, Paul A. Bradley, Graham L. Smith, Lee R. Roberts, Geoff E. Gymer, Katherine S. England, Fox David Nathan Abraham, Steven E. Heasley, Michelle Schmidt, Mark E. Bunnage, Yvette M. Fobian, Jerome Molette, David Fairman, Dack Kevin Neil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6515-6518
A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54aefeeb064c19cd276466bf3d396d04
https://doi.org/10.1016/j.bmcl.2011.08.071
https://doi.org/10.1016/j.bmcl.2011.08.071
Autor:
Colin G. Nichols, Michael A. Tones, Todd E. Haim, Thomas P. Flagg, Anthony Bahinski, Randal E. Numann, Jeanne M. Nerbonne, Wei Wang
Publikováno v:
Journal of Molecular and Cellular Cardiology. 48:395-405
There is considerable evidence to support a role for lipotoxicity in the development of diabetic cardiomyopathy, although the molecular links between enhanced saturated fatty acid uptake/metabolism and impaired cardiac function are poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0694598a4f1fab8f366b110ebf43b0e
https://doi.org/10.1016/j.yjmcc.2009.10.004
https://doi.org/10.1016/j.yjmcc.2009.10.004
Autor:
Michael A. Tones, Sandra Piquet, Eric Paquet, Gabriel D. Bossé, Oussama Meziane, Claude Robert, Martin J. Simard, Dominic Gagné
Publikováno v:
Scientific Reports
The decapping scavenger enzyme DcpS is known for its role in hydrolyzing the cap structure following mRNA degradation. Recently, we discovered a new function in miRNA degradation activation for the ortholog of DcpS in C. elegans. Here we show that hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4477841232038d7aca760ad67fe8eb34
https://pubmed.ncbi.nlm.nih.gov/26584588
https://pubmed.ncbi.nlm.nih.gov/26584588
Publikováno v:
Molecular and Cellular Neuroscience. 18:296-306
Metabotropic glutamate receptor 5 (mGluR5) can modulate synaptic transmission by increasing intracellular Ca2+ and it plays a role in several forms of synaptic plasticity. We have constructed a fusion of human mGluR5 and green fluorescent protein (mG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb26bdc0fbcefe0e21d7f9815b1e101
https://doi.org/10.1006/mcne.2001.1031
https://doi.org/10.1006/mcne.2001.1031
Publikováno v:
NeuroReport. 7:117-120
To test the hypothesis that the determinants for agonist selectivity of class III metabotropic glutamate receptors (mGluRs) are localized in the N-terminal extracellular domain, a chimaeric cDNA was constructed where 519 amino acids of the N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55062ed0aa9e5eade307e25fbfa4297c
https://doi.org/10.1097/00001756-199512290-00028
https://doi.org/10.1097/00001756-199512290-00028