Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Michael A. Teitell"'
Autor:
Peyton J. Tebon, Bowen Wang, Alexander L. Markowitz, Ardalan Davarifar, Brandon L. Tsai, Patrycja Krawczuk, Alfredo E. Gonzalez, Sara Sartini, Graeme F. Murray, Huyen Thi Lam Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Michael A. Teitell, Alice Soragni
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract High throughput drug screening is an established approach to investigate tumor biology and identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not accurately reflect the biology of human tumors. More clini
Externí odkaz:
https://doaj.org/article/cdb49d87278049f08e97471afd0ff5af
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Quantitative phase microscopy (QPM) enables studies of living biological systems without exogenous labels. To increase the utility of QPM, machine-learning methods have been adapted to extract additional information from the quantitative pha
Externí odkaz:
https://doaj.org/article/7752a033f33d43dea83c773f3e54baa9
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101568- (2022)
Summary: Metabolism regulates cell fates during early mammalian cell differentiation. This protocol describes the steps for directed differentiation of primed human pluripotent stem cells (hPSCs) into the three primary germ lineages—ectoderm, endod
Externí odkaz:
https://doaj.org/article/c51457da844140d69837f746cdc23626
Autor:
Alexander J. Sercel, Alexander J. Napior, Alexander N. Patananan, Ting-Hsiang Wu, Pei-Yu Chiou, Michael A. Teitell
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100850- (2021)
Summary: This protocol describes the assembly and use of MitoPunch to deliver mitochondria containing mitochondrial DNA (mtDNA) into cells lacking mtDNA (ρ0 cells). MitoPunch generates stable isolated mitochondrial recipient clones with restored mtD
Externí odkaz:
https://doaj.org/article/de320d3f3d974ca7b8b03cc85f6b537c
Autor:
Arash Pezhouman, Ngoc B. Nguyen, Alexander J. Sercel, Thang L. Nguyen, Ali Daraei, Shan Sabri, Douglas J. Chapski, Melton Zheng, Alexander N. Patananan, Jason Ernst, Kathrin Plath, Thomas M. Vondriska, Michael A. Teitell, Reza Ardehali
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be used as a source for cell delivery to remuscularize the heart after myocardial infarction. Despite their therapeutic potential, the emergence of ventricular arrhythmias ha
Externí odkaz:
https://doaj.org/article/b15067c9d27942a09f1c72c4d61693ac
Autor:
Shen Li, Feiyang Ma, Tomohiro Yokota, Gustavo Garcia Jr., Amelia Palermo, Yijie Wang, Colin Farrell, Yu-Chen Wang, Rimao Wu, Zhiqiang Zhou, Calvin Pan, Marco Morselli, Michael A. Teitell, Sergey Ryazantsev, Gregory A. Fishbein, Johanna ten Hoeve, Valerie A. Arboleda, Joshua Bloom, Barbara Dillon, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Vaithilingaraja Arumugaswami, Arjun Deb
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality rate than pulmonary manifestations. However, little is known about the pathogenesis of systemic complications of COVID-19. Here, we create a murine model of SARS-Co
Externí odkaz:
https://doaj.org/article/5eccd2b0db0941ecae1137cd886d2357
Autor:
Alexander J Sercel, Alexander N Patananan, Tianxing Man, Ting-Hsiang Wu, Amy K Yu, Garret W Guyot, Shahrooz Rabizadeh, Kayvan R Niazi, Pei-Yu Chiou, Michael A Teitell
Publikováno v:
eLife, Vol 10 (2021)
Generating mammalian cells with specific mitochondrial DNA (mtDNA)–nuclear DNA (nDNA) combinations is desirable but difficult to achieve and would be enabling for studies of mitochondrial-nuclear communication and coordination in controlling cell f
Externí odkaz:
https://doaj.org/article/6c21484b522f4026ba665933a074bed6
Autor:
Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan, Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja, David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell, Andrew S. Goldstein
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Background Cancer cell metabolism requires sustained pools of intracellular nicotinamide adenine dinucleotide (NAD+) which is maintained by a balance of NAD+ hydrolase activity and NAD+ salvage activity. We recently reported that human prost
Externí odkaz:
https://doaj.org/article/74edf0c78aa84fd28034f0b9a6de4892
Publikováno v:
iScience, Vol 5, Iss , Pp 99-109 (2018)
Summary: B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports naive B cell activation to enable an effective immune response.
Externí odkaz:
https://doaj.org/article/558153aa07ac42aba37a7a0d62887f41
Autor:
Thang L. Nguyen, Soorya Pradeep, Robert L. Judson-Torres, Jason Reed, Michael A. Teitell, Thomas A. Zangle
Publikováno v:
ACS Nano. 16:11516-11544
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with significant opportunities for biomedical applications. QPI uses the natural phase shift of light as it passes through a transparent object, such as a mammalian cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fbb40f712b833cba681034f8965833
https://doi.org/10.1021/acsnano.1c11507
https://doi.org/10.1021/acsnano.1c11507