The Transcription Factor FoxK Participates with Nup98 To Regulate Antiviral Gene Expression

Autor: Debasis Panda, Beth Gold, Michael A. Tartell, Keiko Rausch, Sergio Casas-Tinto, Sara Cherry

Publikováno v: mBio, Vol 6, Iss 2 (2015)

ABSTRACT Upon infection, pathogen recognition leads to a rapidly activated gene expression program that induces antimicrobial effectors to clear the invader. We recently found that Nup98 regulates the expression of a subset of rapidly activated antiv

Externí odkaz: https://doaj.org/article/0116e6d954844afca527d8d29a1d043c

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Autor: Dong Hee Chung, Partha Karmakar, Michael A Tartell, Andrea M. Klingler, Vishnu C. Damalanka, Markus Hoffmann, Cassandra E Thompson, Sean P. J. Whelan, Matthew Mahoney, Stefan Pöhlmann, Paul W. Rothlauf, Melody Lee, Jorine Voss, Anthony J. O’Donoghue, André Luiz Lourenço, Charles S. Craik, Christina L. Stallings, Marc E. Rothenberg, James W. Janetka, Nurit P. Azouz, Anne E. Mayer Bridwell, Dustin Pwee, Lidija Klampfer

Publikováno v: bioRxiv
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America

Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375bc698f0a068ad5bcd60e5bac8a49a
https://europepmc.org/articles/PMC8204910/

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

Autor: Lindsay Droit, Herbert W. Virgin, Jeffrey P. Henderson, Ma. Xenia G. Ilagan, Stephen Tahan, David Wang, Louis Marie Bloyet, Haiyan Zhao, Davide Corti, Sean P. J. Whelan, Sachdev S. Sidhu, Michael A Tartell, Zhuoming Liu, James Brett Case, Elitza S. Theel, Shane Miersch, Michael S. Diamond, Rita E. Chen, Daved H. Fremont, Siyuan Ding, Arthur S. Kim, Qiru Zeng, Paul W. Rothlauf, Gaya K. Amarasinghe, Mart Ustav

Publikováno v: Cell Host & Microbe
bioRxiv
SSRN

Antibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and possibly transmission. An anticipated correlate of such countermeasures is the level of neutralizing antibodies against the SARS-CoV-2 spike protein, which engages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c558663a41532ccb44b117f69c567bcd
https://pubmed.ncbi.nlm.nih.gov/32910919

The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression

Autor: Keiko Rausch, Debasis Panda, Beth Gold, Michael A. Tartell, Sara Cherry, Sergio Casas-Tintó

Publikováno v: mBio
mBio, Vol 6, Iss 2 (2015)

Upon infection, pathogen recognition leads to a rapidly activated gene expression program that induces antimicrobial effectors to clear the invader. We recently found that Nup98 regulates the expression of a subset of rapidly activated antiviral gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82bab59687617848b255d3304b3ce53
https://pubmed.ncbi.nlm.nih.gov/25852164

Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR

Autor: Robert E. Means, Sabine Lang, Michael A. Tartell, Roshan Karki, Meisha O. F. Bynoe

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e58056 (2013)

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of multicentric Castleman's disease, primary effusion lymphoma and Kaposi's sarcoma. In this study, we show that like the C-type lectin DC-SIGN, the closely related DC-SIGNR can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100555ed8ee9249697a107d0b6226caf
https://doi.org/10.1371/journal.pone.0058056