Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael A. Stanga"'
Publikováno v:
Journal of Cellular Plastics. 33:55-71
Requirements for silicone surfactants for flexible slabstock polyurethane foam are varied and demanding and consideration must be given to new requirements for high water formulations, low density formulations, emulsification of high water levels int
Autor:
Eun-Hong Kim, Lee S. Chong, Radhika Venkataraman, Michael A. Stanga, Jeffrey B. Epp, William C. Groutas, James E. Yoder
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:125-128
A series of isoxazoline derivatives were synthesized and investigated for their in vitro inhibitory activity towards human leukocyte elastase, cathepsin G and proteinase 3.
Autor:
Michael A. Stanga, Jeffrey B. Epp, Lee S. Chong, William C. Groutas, Jerald J. McClenahan, Radhika Venkataraman, Michael J. Brubaker, F. Tagusagawa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1164:283-288
A series of 3-( alkylthio )-N- hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether side chain (compounds 1 an
Autor:
Lee S. Chong, Radhika Venkataraman, Jeffrey B. Epp, Michael A. Stanga, Rongze Kuang, Michael J. Brubaker, William C. Groutas, James C. Castrisos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1163-1168
Several heterocyclic compounds derived from 3-hydroxypyridazopyrimidine-(I), 3-hydroxypyridopyrimidine-(II) and 3-hydroxyquinazoline-2,4(1H,3H)diones-(III) have been found to be time-dependent irreversible inhibitors of human leukocyte elastase.
Autor:
William C. Groutas, Eun-Hong Kim, Michael J. Brubaker, Charles E. Keller, Jeffrey B. Epp, Radhika Venkataraman, Lee S. Chong, Michael A. Stanga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1571-1574
The interaction of a series of derivatives of cis-N-hydroxy-3-phenyl-2-isoxazoline-4,5-dicarboximide toward human leukocyte elastase and cathepsin G was investigated. Both enzymes were rapidly acylated and the corresponding acyl enzymes exhibited var
Autor:
Jeffrey D. Wolt, Frederick R. Batzer, Michael A. Stanga, Jack R. Miller, Lennon H. McKendry, Julie D. Schwake, Debbie L. Holbrook, Stephen M. Brown, Gary A. Roth, David. Portwood
Publikováno v:
Journal of Agricultural and Food Chemistry. 40:2302-2308
The herbicide flumetsulam [N-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sul fonamide] was investigated in sediment-water systems to ascertain anaerobic aquatic degradation as a potential route for dissipation. In a strongly anaer
Publikováno v:
Biochemistry. 30:4132-4136
A series of phosphate esters derived from N-hydroxysuccinimide and 3-alkyl-N-hydroxy-succinimide have been synthesized and found to be potent time-dependent irreversible inhibitors of human leukocyte elastase (HLE). The observed inhibitory activity i
Publikováno v:
Archives of biochemistry and biophysics. 297(1)
(RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human
Autor:
Michael J. Brubaker, Radhika Venkataraman, William C. Groutas, Jeffrey B. Epp, Michael A. Stanga, Jerald J. McClenahan
Publikováno v:
Archives of biochemistry and biophysics. 294(1)
The interaction of a series of sulfonate and phosphate esters derived from N-hydroxysuccinimide with human leukocyte cathepsin G was investigated. The synthesized compounds were found to be time-dependent inhibitors of the enzyme. The composite inter
Autor:
Radhika Venkataraman, Michael A. Stanga, B. H. Gray, Narayanam V. Rao, William C. Groutas, John R. Hoidal, Michael J. Brubaker
Publikováno v:
Journal of medicinal chemistry. 33(4)