Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael A. Slama"'
Autor:
Kihak Gwon, Hye Jin Hong, Alan M. Gonzalez-Suarez, Michael Q. Slama, Daheui Choi, Jinkee Hong, Harihara Baskaran, Gulnaz Stybayeva, Quinn P. Peterson, Alexander Revzin
Publikováno v:
Bioactive Materials, Vol 15, Iss , Pp 1-14 (2022)
Human pluripotent stem cells (hPSC) hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver failure. Some of the challenges that limit the clinical/translational impact of hPSCs are high cost and
Externí odkaz:
https://doaj.org/article/82e304db50db4772875bb07418f55833
Autor:
Pouria Fattahi, Ali Rahimian, Michael Q. Slama, Kihak Gwon, Alan M. Gonzalez-Suarez, Jadon Wolf, Harihara Baskaran, Caden D. Duffy, Gulnaz Stybayeva, Quinn P. Peterson, Alexander Revzin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cellular therapies based on human pluripotent stem cells (hPSCs) offer considerable promise for treating numerous diseases including diabetes and end stage liver failure. Stem cell spheroids may be cultured in stirred bioreactors to scale up
Externí odkaz:
https://doaj.org/article/53e0a7662aba4e918a6dcc5423f60520
Autor:
Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression
Externí odkaz:
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
Autor:
Li Zhan, Joseph Sushil Rao, Nikhil Sethia, Michael Q. Slama, Zonghu Han, Diane Tobolt, Michael Etheridge, Quinn P. Peterson, Cari S. Dutcher, John C. Bischof, Erik B. Finger
Publikováno v:
Nature Medicine. 28:798-808
Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets in sufficient quantities. Cryopreservation could solve islet supply chain challenges by enabling quality-controlled banking and pooling of donor islets. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f0046a90c232cffea5a08a4a42aac32
https://doi.org/10.1038/s41591-022-01718-1
https://doi.org/10.1038/s41591-022-01718-1
Autor:
Quan Zhou, Maria Sörhede-Winzell, Douglas A. Melton, Shaimaa Hassoun, Jennifer H. R. Kenty, Aleksey V. Matveyenko, Matthew R. Brown, Caden D. Duffy, Adrian Veres, Björn Tyrberg, Patrik Rorsman, Michael Q. Slama, Lihua Chen, Quinn P. Peterson, Haiqiang Dou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused on generating pancreatic beta cells, considerable evidence indicates that glucagon secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1830555d671cc5d40102c6a337558a27
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
Autor:
Joseph Sushil Rao, Li Zhan, Nikhil Sethia, Michael Q. Slama, Zonghu Han, Diane Tobolt, Michael Ethridge, Quinn P. Peterson, Cari S. Dutcher, John C. Bischof, Erik B. Finger
Publikováno v:
Cryobiology. 109:20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e7338fb49c4424b3468da022a196579
https://doi.org/10.1016/j.cryobiol.2022.11.064
https://doi.org/10.1016/j.cryobiol.2022.11.064
Autor:
Gulnaz Stybayeva, Doo Sup Choi, Harihara Baskaran, Michael Q. Slama, Kihak Gwon, Alexander Revzin, Alan M. Gonzalez-Suarez, Hye Jin Hong, Quinn P. Peterson, Jong Kwang Hong
Human pluripotent stem cells (hPSC) hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver failure. Some of the challenges that limit the clinical/translational impact of hPSCs are high cost and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6c172fe26b011f73f81f4a4ef3b39ac
https://doi.org/10.1101/2021.09.21.461208
https://doi.org/10.1101/2021.09.21.461208
Autor:
Li, Zhan, Joseph Sushil, Rao, Nikhil, Sethia, Michael Q, Slama, Zonghu, Han, Diane, Tobolt, Michael, Etheridge, Quinn P, Peterson, Cari S, Dutcher, John C, Bischof, Erik B, Finger
Publikováno v:
Nature medicine. 28(4)
Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets in sufficient quantities. Cryopreservation could solve islet supply chain challenges by enabling quality-controlled banking and pooling of donor islets. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7a3600c5420cefc19e1d6982a5ec563
https://pubmed.ncbi.nlm.nih.gov/35584645
https://pubmed.ncbi.nlm.nih.gov/35584645
Autor:
Carrie J. Heppelmann, Subhasish Tapadar, Adegboyega K. Oyelere, Jin Sung Jang, Quinn P. Peterson, Aleksey V. Matveyenko, Chong Hyun Shin, Yun Fang Jia, Jin Xu, Subbiah Jeeva, Michael Q. Slama, Sang-Moo Kang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852367504420221c941eed7e69c81422
https://doi.org/10.1038/s41598-020-76600-6
https://doi.org/10.1038/s41598-020-76600-6
Autor:
Michele Schiavon, Xuan Mai Petterson, Michael Q. Slama, Ananda Basu, Rita Basu, Rickey E. Carter, Chiara Dalla Man, Ling Hinshaw, Claudio Cobelli
Publikováno v:
Am J Physiol Endocrinol Metab
While the triple tracer isotope dilution method has enabled accurate estimation of carbohydrate turnover after a mixed meal, use of the simple carbohydrate glucose as the carbohydrate source limits its translational applicability to everyday meals th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c4634c3d186a0c952581a0170f7660
http://hdl.handle.net/11577/3332226
http://hdl.handle.net/11577/3332226