Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michael A. Siani"'
Publikováno v:
International Journal of Peptide and Protein Research. 40:497-506
A fully automated peptide synthesizer has been constructed that is capable of the synthesis of equimolar peptide mixtures and the simultaneous synthesis of 36 individual peptides. The synthesizer was constructed from a workstation of our own design u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6900bc51796e618938e9ecd8e6ffe34e
https://doi.org/10.1111/j.1399-3011.1992.tb00433.x
https://doi.org/10.1111/j.1399-3011.1992.tb00433.x
Autor:
David Kulp, Jill Cheng, Michael A. Siani-Rose, David Finkelstein, Tarif Awad, Melissa S. Cline, John Martin
Publikováno v:
Journal of Biopharmaceutical Statistics. 14:687-700
We have developed an algorithm for inferring the degree of similarity between genes by using the graph-based structure of Gene Ontology (GO). We applied this knowledge-based similarity metric to a clique-finding algorithm for detecting sets of relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a229e15eea9028fd698dab45405dc05c
https://doi.org/10.1081/bip-200025659
https://doi.org/10.1081/bip-200025659
Autor:
Hui Wang, Jing-shan Hu, Melissa S. Cline, David Kulp, Manuel Ares, Tyson A. Clark, David Haussler, Gang Lu, Michael A. Siani-Rose, Earl Hubbell, Gangwu Mei
Publikováno v:
ISMB (Supplement of Bioinformatics)
Motivation: Alternative splicing allows a single gene to generate multiple mRNAs, which can be translated into functionally and structurally diverse proteins. One gene can have multiple variants coexisting at different concentrations. Estimating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9630a79344669565033f0816cd34d198
https://doi.org/10.1093/bioinformatics/btg1044
https://doi.org/10.1093/bioinformatics/btg1044
Autor:
Hilary L.E. Rood, Darren A. Thompson, Biaoxin Chai, Glenn L. Millhauser, Nicholai R. Douglas, Michael A. Siani, Ira Gantz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1409-1413
The Agouti Related Protein (AGRP) is an endogenous antagonist of melanocortin-3 and -4 receptors, each of which plays a key role in body weight homeostasis. We designed a peptoid trimer based on AGRP 111-113 in which a single chiral atom is used to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec44cdeb0aea3c4602a0274eaa5e219e
https://doi.org/10.1016/s0960-894x(03)00164-1
https://doi.org/10.1016/s0960-894x(03)00164-1
Publikováno v:
Analytical Biochemistry. 300:146-151
A synthetic gene for the human motilin receptor containing 33 unique restriction sites was designed and stably coexpressed in HEK293 cells with the bioluminescent Ca(2+) indicator protein aequorin. The dose-dependent response of the receptor to motil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec6a05f37944e895be34be3325c930e
https://doi.org/10.1006/abio.2001.5466
https://doi.org/10.1006/abio.2001.5466
Autor:
Patrick Hildbrand, Luc J. W. van der Laan, Bruce E. Torbett, Michael A. Siani, Anthony J. Pelletier, Philip E. Dawson, Daniel R. Salomon, Darren A. Thompson
Publikováno v:
Blood. 96:2682-2690
The role of chemokine–matrix interactions in integrin-dependent T-cell migration was examined to address the critical question of how chemokines provide directional information. The chemokine SDF-1α binds fibronectin (Fn) with a low nanomolar Kd(e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa17c1230e05b402bad165072805ac
https://doi.org/10.1182/blood.v96.8.2682.h8002682_2682_2690
https://doi.org/10.1182/blood.v96.8.2682.h8002682_2682_2690
Publikováno v:
Gene. 247:97-102
An approach is described for obtaining 'perfect probes' for type I modular polyketide synthase (PKS) gene clusters that in turn enables the identification of all such gene clusters in a genome. The approach involves sequencing small fragments of a ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28b6e3c950e0db3dcc23bc163bede62
https://doi.org/10.1016/s0378-1119(00)00113-x
https://doi.org/10.1016/s0378-1119(00)00113-x
Autor:
Daniel V. Santi, A. Geoffrey Skillman, Irwin D. Kuntz, Christopher Carreras, Michael A. Siani, Gary W. Ashley
Publikováno v:
Journal of Molecular Graphics and Modelling. 18:497-511
A virtual library of macrocyclic polyketide molecules was generated and screened to identify novel, conformationally constrained potential motilin receptor agonists (“motilides”). A motilide pharmacophore model was generated from the potent 6,9-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e9bae19966c488c6e833aa120db98e
https://doi.org/10.1016/s1093-3263(00)00070-x
https://doi.org/10.1016/s1093-3263(00)00070-x
Autor:
Albert Zlotnik, Michael A. Siani, James Campbell, Joseph A. Hedrick, Darren A. Thompson, Eugene C. Butcher
Publikováno v:
Science. 279:381-384
Circulating lymphocytes are recruited from the blood to the tissue by rolling along the endothelium until being stopped by a signaling event linked to the Giα subunit of a heterotrimeric GTP-binding protein; that event then triggers rapid integrin-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c55b537e385ad895f424f9612ad9528
https://doi.org/10.1126/science.279.5349.381
https://doi.org/10.1126/science.279.5349.381
Autor:
Lili Feng, David Lo, Shizhong Chen, Kevin Bacon, Darren A. Thompson, Li Li, Gabriela E. Garcia, Yiyang Xia, Jeffrey K. Harrison, Tadashi Yamamoto, Michael A. Siani
Publikováno v:
The Journal of Experimental Medicine
Chemokines play a central role in immune and inflammatory responses. It has been observed recently that certain viruses have evolved molecular piracy and mimicry mechanisms by encoding and synthesizing proteins that interfere with the normal host def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716ab46878e73395cf16aa3e06f24347
http://europepmc.org/articles/PMC2525551
http://europepmc.org/articles/PMC2525551