Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Michael A. Rudnicki"'
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We have recently made the strikingly discovery that upon a muscle injury, Wnt7a is upregulated and secreted from new regenerating myofibers on the surface of exosomes to elicit its myogenerative response distally. Despite recent advances in
Externí odkaz:
https://doaj.org/article/b98878e1ad2e45b9839dc889787c43aa
Autor:
Kasun Kodippili, Michael A. Rudnicki
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Progressive muscle weakness and degeneration characterize Duchenne muscular dystrophy (DMD), a lethal, x-linked neuromuscular disorder that affects 1 in 5,000 boys. Loss of dystrophin protein leads to recurrent muscle degeneration, progressive fibros
Externí odkaz:
https://doaj.org/article/ecae9cd0dc444a308ce921afeac29cc2
Autor:
Caroline E. Brun, Marie-Claude Sincennes, Alexander Y. T. Lin, Derek Hall, William Jarassier, Peter Feige, Fabien Le Grand, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.
Externí odkaz:
https://doaj.org/article/029f9948098341d7a5dbb5349abfd906
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Skeletal muscle has a remarkable capacity to regenerate throughout life, which is mediated by its resident muscle stem cells, also called satellite cells. Satellite cells, located periphery to the muscle fibers and underneath the basal lamina, are an
Externí odkaz:
https://doaj.org/article/9435cf5879a5402982a397d1be77ec0f
Autor:
Marie-Claude Sincennes, Caroline E. Brun, Alexander Y. T. Lin, Tabitha Rosembert, David Datzkiw, John Saber, Hong Ming, Yoh-ichi Kawabe, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The acetyltransferase MYST1 stimulated by acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD+, regulate PAX7 acetylation in muscle stem cells, which in turn, regulates stem cell self-renewal and regeneration following injury in mouse skeletal mu
Externí odkaz:
https://doaj.org/article/24a0e0653321457e90cacbe83a5277e7
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background Maintaining stem cells in physiologically relevant states is necessary to understand cell and context-specific signalling paradigms and to understand complex interfaces between cells in situ. Understanding human stem cell function
Externí odkaz:
https://doaj.org/article/0e66820fa3bf4bc6ac686df0cc30cff3
Autor:
Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4
Externí odkaz:
https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
Publikováno v:
Open Biology, Vol 10, Iss 5 (2020)
Individuals that maintain healthy skeletal tissue tend to live healthier, happier lives as proper muscle function enables maintenance of independence and actuation of autonomy. The onset of skeletal muscle decline begins around the age of 30, and mus
Externí odkaz:
https://doaj.org/article/cfe5a68370ff46d6af0311c09747b508
Publikováno v:
F1000Research, Vol 9 (2020)
Satellite cells are the main muscle-resident cells responsible for muscle regeneration. Much research has described this population as being heterogeneous, but little is known about the different roles each subpopulation plays. Recent advances in the
Externí odkaz:
https://doaj.org/article/3d8bf330750a4c5c90955f77950b01a2
Autor:
Ori Bar-Nur, Mattia F.M. Gerli, Bruno Di Stefano, Albert E. Almada, Amy Galvin, Amy Coffey, Aaron J. Huebner, Peter Feige, Cassandra Verheul, Priscilla Cheung, Duygu Payzin-Dogru, Sylvain Paisant, Anthony Anselmo, Ruslan I. Sadreyev, Harald C. Ott, Shahragim Tajbakhsh, Michael A. Rudnicki, Amy J. Wagers, Konrad Hochedlinger
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1505-1521 (2018)
Summary: Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative progenitors termed myoblasts, which play pivotal roles during muscle regeneration. However, current technology does not allow permanent capture of these ce
Externí odkaz:
https://doaj.org/article/a15bbb95518c4bcfac9f9bdefbfc29a6