Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Michael A. Rogawski"'
Autor:
Donald A. Bruun, Betty Ma, Yi‐Je Chen, Chun‐Yi Wu, Monica Aleman, Dorota Zolkowska, Suzette M. Smiley‐Jewell, Michael A. Rogawski, Pamela J. Lein
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 666-672 (2023)
Abstract The neurosteroid allopregnanolone (ALLO) is under investigation as a treatment for benzodiazepine‐refractory status epilepticus (SE). Here, we assess the cardiopulmonary safety of intravenous ALLO by itself and after a clinically recommend
Externí odkaz:
https://doaj.org/article/b46ab8137891425b998225dccd024a77
Autor:
Michelle Guignet, Kiran Dhakal, Brenna M. Flannery, Brad A. Hobson, Dorota Zolkowska, Ashish Dhir, Donald A. Bruun, Shuyang Li, Abdul Wahab, Danielle J. Harvey, Jill L. Silverman, Michael A. Rogawski, Pamela J. Lein
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
Current medical countermeasures for organophosphate (OP)-induced status epilepticus (SE) are not effective in preventing long-term morbidity and there is an urgent need for improved therapies. Rat models of acute intoxication with the OP, diisopropyl
Externí odkaz:
https://doaj.org/article/738218b0f62a47c78297d897468feddf
Autor:
Gerson D. Hernandez, Christine M. Solinsky, Wendy J. Mack, Naoko Kono, Kathleen E. Rodgers, Chun‐Yi Wu, Ana R. Mollo, Claudia M. Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A. Rogawski, Lon S. Schneider, Roberta D. Brinton
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy m
Externí odkaz:
https://doaj.org/article/5850674a3da74dfebad3206ffcd3f5dc
Autor:
Chao-Yin Chen, Jacopo Di Lucente, Yen-Chu Lin, Cheng-Chang Lien, Michael A. Rogawski, Izumi Maezawa, Lee-Way Jin
Publikováno v:
Neurobiology of Disease, Vol 109, Iss , Pp 25-32 (2018)
Rett syndrome (RTT) is a devastating neurodevelopmental disorder caused by loss-of-function mutations in the X-linked methyl-CpG binding protein 2 (Mecp2) gene. GABAergic dysfunction has been implicated contributing to the respiratory dysfunction, on
Externí odkaz:
https://doaj.org/article/f3ee4a541aa94860b8d209fb1e836a20
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 3, Pp 378-384 (2012)
Ion channels, specifically voltage-gated sodium channels (Navs), are common culprits in inheritable seizure disorders. Some Nav isoforms are particularly susceptible, while others are only weakly associated with neuronal hyperexcitability. Representa
Externí odkaz:
https://doaj.org/article/20982a824d5543f79a62509893e271f3
Autor:
Anthony S. Basile, Elena Koustova, P. Ioan, S. Rizzoli, Michael A. Rogawski, Peter N.R. Usherwood
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 6, Pp 1069-1081 (2001)
Biochemical and immunological studies have shown that mice infected with LP-BM5 virus develop antibodies to ionotropic glutamate receptors. Here, IgG isolated from brain of infected mice has been tested electrophysiologically on cultured rat cortical
Externí odkaz:
https://doaj.org/article/42616dc36a624019861339009b958170
Autor:
Michael A. Rogawski, Gary Slatko
Publikováno v:
EpilepsiaREFERENCES.
The pharmacokinetics of oral diazepam are affected by food, but food-effect studies have not been conducted for diazepam nasal spray because it is believed that most absorption occurs via the nasal mucosa. However, gastrointestinal side effects repor
Autor:
Stephen F, Traynelis, Dennis, Dlugos, David, Henshall, Heather C, Mefford, Michael A, Rogawski, Kevin J, Staley, Penny A, Dacks, Vicky, Whittemore, Annapurna, Poduri
Publikováno v:
Epilepsy Currents
The goals of Epilepsy Benchmark Area III involve identifying areas that are ripe for progress in terms of controlling seizures and patient symptoms in light of the most recent advances in both basic and clinical research. These goals were developed w
Publikováno v:
Archives of toxicology, vol 95, iss 7
Archives of Toxicology
Archives of Toxicology
Tetramethylenedisulfotetramine (TETS), a noncompetitive GABAA receptor antagonist, is a potent, highly lethal convulsant that is considered to be a chemical threat agent. Here, we assessed the ability of the AMPA receptor antagonist perampanel to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcb81da4270ed2c49341ca2a61419c2
https://escholarship.org/uc/item/476074tc
https://escholarship.org/uc/item/476074tc
Autor:
Vaclav Kremen, Ilo E. Leppik, Gregory A. Worrell, James C. Cloyd, Irene Vuu, Dorota Zolkowska, Michael A. Rogawski, Lisa D. Coles, Edward E. Patterson, Chun-Yi Wu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 380(2)
Allopregnanolone (ALLO) is a neurosteroid that modulates synaptic and extrasynaptic GABAA receptors. We hypothesize that ALLO may be useful as first-line treatment for status epilepticus (SE). Our objectives were to 1) characterize ALLO pharmacokinet