Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael A. Ringenberg"'
Autor:
Douglas A. Donahue, Cristina Ballesteros, Giulietta Maruggi, Christiana Glover, Michael A. Ringenberg, Miriam Marquis, Nawel Ben Abdeljelil, Asma Ashraf, Luis-Alexander Rodriguez, Alan H. Stokes
Publikováno v:
International Journal of Toxicology. 42:37-49
Vaccines containing mRNA with the capacity to self-amplify represent an alternative to the mRNA vaccines that came to prominence during the COVID-19 pandemic. To gain further insights on the safety profile of self-amplifying mRNA- (SAM-) vaccines, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a62f606e0975540407862a152a3bf5
https://doi.org/10.1177/10915818221138781
https://doi.org/10.1177/10915818221138781
Autor:
Giulietta Maruggi, Corey P. Mallett, Jason W. Westerbeck, Tiffany Chen, Giuseppe Lofano, Kristian Friedrich, Lin Qu, Jennifer Tong Sun, Josie McAuliffe, Amey Kanitkar, Kathryn T. Arrildt, Kai-Fen Wang, Ian McBee, Deborah McCoy, Rebecca Terry, Alison Rowles, Maia Araujo Abrahim, Michael A. Ringenberg, Malcolm J. Gains, Catherine Spickler, Xuping Xie, Jing Zou, Pei-Yong Shi, Taru Dutt, Marcela Henao-Tamayo, Izabela Ragan, Richard A. Bowen, Russell Johnson, Sandra Nuti, Kate Luisi, Jeffrey B. Ulmer, Ann-Muriel Steff, Rashmi Jalah, Sylvie Bertholet, Alan H. Stokes, Dong Yu
Publikováno v:
Molecular Therapy
RNA vaccines have demonstrated efficacy against SARS-CoV-2 in humans and the technology, is being leveraged for rapid emergency response. In this report, we assessed immunogenicity, and, for the first time, toxicity, biodistribution and protective ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8ac8597c1bbd871ec96b10ef6faf90
https://doi.org/10.1016/j.ymthe.2022.01.001
https://doi.org/10.1016/j.ymthe.2022.01.001
Autor:
Jong W Yu, Sandy Hoffman, Allison M Beal, Angela Dykon, Michael A Ringenberg, Anna C Hughes, Lauren Dare, Amber D Anderson, Joshua Finger, Viera Kasparcova, David Rickard, Scott B Berger, Joshi Ramanjulu, John G Emery, Peter J Gough, John Bertin, Kevin P Foley
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127083 (2015)
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a scaffolding protein to activate NF-κB through recruitment o
Externí odkaz:
https://doaj.org/article/327f71770e43439cbfdc0ac0b47f3d3d
Autor:
Ornella Binazon, Marie-Noëlle Donner, Alan H. Stokes, Vimala Vemireddi, Luis-Alexander Rodriguez, Daniel E Fisher, Lorraine M. Posobiec, Jeffrey H. Charlap, Mary K. Ziejewski, Niraj Tripathi, Ritankar Majumdar, Payal Khanna Weiss, Judith Baumeister, Kelle Franklin, Badiaa Bouzya, Michael Alan Ringenberg
Publikováno v:
International journal of toxicology. 40(2)
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, and vaccines are needed to treat young children and older adults. One of GSK’s candidate vaccines for RSV contains recombinant RSVPreF3 protein mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8028a8759cd0d0e4c2dbe99fc2241c0
https://pubmed.ncbi.nlm.nih.gov/33517807
https://pubmed.ncbi.nlm.nih.gov/33517807
Autor:
Benoit Laffont, Guillaume Dubois, Alan Stokes, Karine Blouin, Maude Bigras, Julius Haruna, Luis-Alexander Rodriguez, Michael Alan Ringenberg, Nawel Ben Abdeljelil, Jamie K. Young, Johanne Pion, Ornella Binazon
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 113
The novel self-amplifying mRNA (SAM) technology for vaccines consists of an engineered replication-deficient alphavirus genome encoding an RNA-dependent RNA polymerase and the gene of the target antigen. To validate the concept, the rabies glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f5d1ee6c3e8fc0c11355be7324b5bb
https://pubmed.ncbi.nlm.nih.gov/32240713
https://pubmed.ncbi.nlm.nih.gov/32240713
Autor:
Martin van Velsen, Octav Popescu, Jonathan Sewall, Bruce M. McLaren, Michael A. Ringenberg, Sandra Demi, Kenneth R. Koedinger, Vincent Aleven
Publikováno v:
International Journal of Artificial Intelligence in Education. 26:224-269
In 2009, we reported on a new Intelligent Tutoring Systems (ITS) technology, example-tracing tutors, that can be built without programming using the Cognitive Tutor Authoring Tools (CTAT). Creating example-tracing tutors was shown to be 4–8 times a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb7641ee5cc68ceb3d3a6b6b60d72ba
https://doi.org/10.1007/s40593-015-0088-2
https://doi.org/10.1007/s40593-015-0088-2
Publikováno v:
Toxicologic pathology. 46(6)
Nephrotoxicity is one of the more common causes of attrition in nonclinical drug development. Like most tissues, the kidney has a limited number of ways of responding to toxicological insults from diverse mechanistic pathways, which can limit the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c870b4b7ebad7d50d6c9d1fd289d3ab9
https://pubmed.ncbi.nlm.nih.gov/30049250
https://pubmed.ncbi.nlm.nih.gov/30049250
Publikováno v:
Comparative medicine. 67(5)
Coccidioides spp. are saprophytic, dimorphic fungi that are endemic to arid climates, are capable of infecting many species, and result in diverse clinical presentations. An indoor-housed laboratory rhesus macaque presented with weight loss and decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57986b6af51ce0f0b231a9f9a03c94f5
https://pubmed.ncbi.nlm.nih.gov/28935008
https://pubmed.ncbi.nlm.nih.gov/28935008
Autor:
Jonathan Sewall, Martin van Velsen, Sandra Demi, Michael A. Ringenberg, Octav Popescu, Vincent Aleven
Publikováno v:
Intelligent Tutoring Systems ISBN: 9783319395821
ITS
ITS
Intelligent tutoring systems ITS and MOOCs tend to have complementary pedagogical approaches, but their combination is rarely if ever seen. A key obstacle may be technical integration. We present a generalizable case study of extending ITS authoring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::677f0b28458763081c3737f465d954f6
https://doi.org/10.1007/978-3-319-39583-8_49
https://doi.org/10.1007/978-3-319-39583-8_49
Autor:
Colin H. Macphee, Gregory H. Turner, Michael A. Ringenberg, Carla A. Cornejo, Robert N. Willette, Alan R. Olzinski, Pu Qin, Clark A. Sehon, Karpagam Aravindhan, Bao Hoang, Roberta E. Bernard, Heather Karr, Krista B. Goodman, Beat M. Jucker, Peter J. Gough
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:253-259
Purpose— This study assessed the pharmacological effect of a novel selective C-C chemokine receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage infiltration into atherosclerotic plaque using magnetic resonance imaging (MRI) in an athero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab2e77f40627df4b450e0be2e8443e1
https://doi.org/10.1161/atvbaha.109.198812
https://doi.org/10.1161/atvbaha.109.198812