The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular Diseases

Autor: Isaac M. Emon, Ruaa Al-Qazazi, Michael J. Rauh, Stephen L. Archer

Publikováno v: Cells, Vol 12, Iss 21, p 2528 (2023)

DNA methylation is an epigenetic mechanism that regulates gene expression without altering gene sequences in health and disease. DNA methyltransferases (DNMTs) are enzymes responsible for DNA methylation, and their dysregulation is both a pathogenic

Externí odkaz: https://doaj.org/article/1b5a843719ae49199b46664b35133c85

U2AF1S34/Q157 Variants Detected in cis Arise Sequentially in an MDS Patient With Serial Sequencing Spanning 18 Years

Autor: Christina K. Ferrone, Amy J. M. McNaughton, Felicia Vincelli, Philip Zuzarte, David Lee, Harriet E. Feilotter, Michael J. Rauh

Publikováno v: HemaSphere, Vol 6, Iss 10, p e779 (2022)

Externí odkaz: https://doaj.org/article/13997812124b41fd98d43785adbb831a

Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis

Autor: Elina K. Cook, Terumi Izukawa, Sherylan Young, Gili Rosen, Mina Jamali, Liying Zhang, Dylan Johnson, Eva Bain, Jamie Hilland, Christina K. Ferrone, Jonah Buckstein, Janika Francis, Bushra Momtaz, Amy J.M. McNaughton, Xudong Liu, Brooke Snetsinger, Rena Buckstein, Michael J. Rauh

Publikováno v: Blood Advances, Vol 3, Iss 16, Pp 2482-2486 (2019)

Externí odkaz: https://doaj.org/article/cd938ca649564fcbb3bb2a49f9882316

Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population

Autor: Bryan Kestenbaum, Alexander G. Bick, Caitlyn Vlasschaert, Michael J. Rauh, Matthew B. Lanktree, Nora Franceschini, Moore B. Shoemaker, Raymond C. Harris, Bruce M. Psaty, Anna Köttgen, Pradeep Natarajan, Cassianne Robinson-Cohen

Publikováno v: American Journal of Kidney Diseases. 81:329-335

Clonal hematopoiesis of indeterminate potential (CHIP), defined by the age-related ontogenesis of expanded leukemogenic mutations indicative of a genetically distinct clonal leukocyte population, is associated with risk of hematologic malignancy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a59b112c6442a84241dacc29c6031c
https://doi.org/10.1053/j.ajkd.2022.08.014

Returning to Activity After Anterior Cruciate Ligament Revision Surgery: An Analysis of the Multicenter Anterior Cruciate Ligament Revision Study (MARS) Cohort at 2 Years Postoperative

Autor: John P, Bigouette, Erin C, Owen, Brett Brick A, Lantz, Rudolf G, Hoellrich, Rick W, Wright, Laura J, Huston, Amanda K, Haas, Christina R, Allen, Daniel E, Cooper, Thomas M, DeBerardino, Warren R, Dunn, Kurt P, Spindler, Michael J, Stuart, John P, Albright, Annunziato Ned, Amendola, Christopher C, Annunziata, Robert A, Arciero, Bernard R, Bach, Champ L, Baker, Arthur R, Bartolozzi, Keith M, Baumgarten, Jeffery R, Bechler, Jeffrey H, Berg, Geoffrey A, Bernas, Stephen F, Brockmeier, Robert H, Brophy, Charles A, Bush-Joseph, J, Brad Butler V, James L, Carey, James E, Carpenter, Brian J, Cole, Jonathan M, Cooper, Charles L, Cox, R, Alexander Creighton, Tal S, David, David C, Flanigan, Robert W, Frederick, Theodore J, Ganley, Elizabeth A, Garofoli, Charles J, Gatt, Steven R, Gecha, James, Robert Giffin, Sharon L, Hame, Jo A, Hannafin, Christopher D, Harner, Norman Lindsay, Harris, Keith S, Hechtman, Elliott B, Hershman, David C, Johnson, Timothy S, Johnson, Morgan H, Jones, Christopher C, Kaeding, Ganesh V, Kamath, Thomas E, Klootwyk, Bruce A, Levy, C, Benjamin Ma, G Peter, Maiers, Robert G, Marx, Matthew J, Matava, Gregory M, Mathien, David R, McAllister, Eric C, McCarty, Robert G, McCormack, Bruce S, Miller, Carl W, Nissen, Daniel F, O'Neill, Brett D, Owens, Richard D, Parker, Mark L, Purnell, Arun J, Ramappa, Michael A, Rauh, Arthur C, Rettig, Jon K, Sekiya, Kevin G, Shea, Orrin H, Sherman, James R, Slauterbeck, Matthew V, Smith, Jeffrey T, Spang, Ltc, Steven J Svoboda, Timothy N, Taft, Joachim J, Tenuta, Edwin M, Tingstad, Armando F, Vidal, Darius G, Viskontas, Richard A, White, James S, Williams, Michelle L, Wolcott, Brian R, Wolf, James J, York

Publikováno v: Am J Sports Med

Background: Patients with anterior cruciate ligament (ACL) revision report lower outcome scores on validated knee questionnaires postoperatively compared to cohorts with primary ACL reconstruction. In a previously active population, it is unclear if

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e9dfeca3ee316d6b6b616f66da1bb8
https://pubmed.ncbi.nlm.nih.gov/35648628