Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michael A. Portelli"'
Autor:
Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Object
Externí odkaz:
https://doaj.org/article/b98b2138b6a345bba5e4c156f9115f19
Autor:
Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/ddb2c536e99642c9b3bab43b9ceb0b9b
Publikováno v:
Frontiers in Allergy, Vol 2 (2021)
Asthma affects more than 300 million people globally and is both under diagnosed and under treated. The most recent and largest genome-wide association study investigating moderate to severe asthma to date was carried out in 2019 and identified 25 in
Externí odkaz:
https://doaj.org/article/a8b1f2f2ce564bd298a06dd51d171aed
Autor:
Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Externí odkaz:
https://doaj.org/article/3c3cfae19b254f35bbc5345f4b26032c
Autor:
Sangita Bhaker, Michael A. Portelli, Robert J. Hall, David O. Bates, Ian Sayers, Vincent Pang, Amanda P. Henry, Tyson V. Sharp, Jonathan O'Loughlin
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Autor:
David O. Bates, Vincent Pang, Judith M. Vonk, Charlote K. Billington, John W. Holloway, Sangita Bhaker, Cornelis J. Vermeulen, Don D. Sin, Ian Sayers, Martin D. Tobin, Peter H. Howarth, F. Nicole Dijk, David C. Nickle, Ian P. Hall, Yohan Bossé, Louise V. Wain, Dominick E. Shaw, John D Blakey, Andrew M. Fogarty, Amisha Singapuri, Michael A. Portelli, Martijn C. Nawijn, Cheng J. Xu, Andrew V. Benest, Ma'en Obeidat, Liam G Heaney, Jenny Hankinson, Maarten van den Berge, Rekha Chaudhuri, Angela Simpson, Tricia M. McKeever, Simon R. Johnson, Adel H. Mansur, Robert Niven, Zara Pogson, Gabrielle A. Lockett, Christopher E. Brightling, Amanda P. Henry, Neil C. Thomson, Nick Shrine, Gerard H. Koppelman, Maria Ketelaar, Alen Faiz
Publikováno v:
Journal of Allergy and Clinical Immunology, 147(1), 144-157. MOSBY-ELSEVIER
Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevated in sp
Publikováno v:
Encyclopedia of Respiratory Medicine ISBN: 9780081027240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5d722631944c73d5d4c7af896827ac
https://doi.org/10.1016/b978-0-08-102723-3.00155-4
https://doi.org/10.1016/b978-0-08-102723-3.00155-4
Autor:
Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers
Publikováno v:
ERJ open research. 8(1)
Autor:
David J. Cousins, Ian Sayers, Dominick E. Shaw, Rebecca Cooper, Michael A. Portelli, Marco Londei, Simon R. Johnson, Christopher E. Brightling
Publikováno v:
Airway cell biology and immunopathology.
Rhinovirus (RV) is a major trigger of asthma exacerbations. RV infection of the bronchial epithelium leads to interleukin-33 (IL-33) release, driving local inflammation. The role of IL-33 release in asthmatic airways on virally induced mechanisms in
Autor:
Dominick E. Shaw, Simon R. Johnson, Christopher E. Brightling, Ian Sayers, Michael A. Portelli, Marco Londei
Publikováno v:
Genes and environment.