Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael A. Nukkala"'
Autor:
Kenneth J. Barr, Laura Gehrke, Hing L. Sham, Michael A. Nukkala, Jang Lee, Shi Chung Ng, Nicolette A. Zielinski, Stephen L. Gwaltney, Michael C. Fitzgerald, Stephen K. Tahir, R. Bruce Credo, Akiyo Claiborne, Robert B. Warner, Keith W. Woods, Gang Liu, Ki H. Kim, David Frost, Yu Hua Hui, Kennan C. Marsh, Qun Li, Saul H. Rosenberg, Peter Kovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:465-469
A series of indole containing oxazolines has been discovered as a result of structural modifications of the lead compound A-105972. The compounds exert their anticancer activity through inhibition of tubulin polymerization by binding at the colchicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59399b6a8e6b6f1c5bbc068b46d3c2d5
https://doi.org/10.1016/s0960-894x(01)00759-4
https://doi.org/10.1016/s0960-894x(01)00759-4
Autor:
Akiyo Claiborne, Gang Liu, David Frost, Ken Jarvis, Jeffery D. Alder, Thomas W. von Geldern, and Qun Li, Joy Bauch, Laura Gehrke, William J. Chiou, Gunawardana Indrani W, Saul H. Rosenberg, Andrew Tasker, Jae Hwan-Soo, Bruce G. Szczepankiewicz, R. Bruce Credo, Yu Hua Hui, Michael A. Nukkala, Nicolette A. Zielinski, J. Ruth Wu-Wong, Stephen L. Gwaltney, Karl W. Mollison
Publikováno v:
Journal of Medicinal Chemistry. 44:4416-4430
During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af95cb1724b235389be978fd3f83efc
https://doi.org/10.1021/jm010231w
https://doi.org/10.1021/jm010231w
Autor:
Kenneth J. Barr, Hovis M. Imade, Robert B. Warner, David Frost, Stephen L. Gwaltney, Jang Yun Lee, Hing L. Vernon Hills Sham, R. Bruce Credo, Peter Kovar, Jieyi Wang, Laura Gehrke, Qun Li, Nicolette A. Zielinski, Shi Chung Ng, Michael A. Nukkala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:871-874
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2f5d2d512fac2dd2b467a6f39dc468
https://doi.org/10.1016/s0960-894x(01)00098-1
https://doi.org/10.1016/s0960-894x(01)00098-1
Autor:
Stephen K, Tahir, Michael A, Nukkala, Nicolette A, Zielinski Mozny, R Bruce, Credo, Robert B, Warner, Qun, Li, Keith W, Woods, Akiyo, Claiborne, Stephen L, Gwaltney, David J, Frost, Hing L, Sham, Saul H, Rosenberg, Shi-Chung, Ng
Publikováno v:
Molecular cancer therapeutics. 2(3)
In this report, we describe the antitumor activity of A-289099, an indolyloxazoline derivative with antimitotic activity. A-289099 decreased the proliferation of a variety of cells with EC(50) values ranging from 5.1 to 12.8 nM in a P-glycoprotein-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c4f060cd432a53b360c7ff46a346800
https://pubmed.ncbi.nlm.nih.gov/12657717
https://pubmed.ncbi.nlm.nih.gov/12657717