Zobrazeno 1 - 10
of 588
pro vyhledávání: '"Michael A. Newton"'
Autor:
Won Jong Jin, Justin C. Jagodinsky, Jessica M. Vera, Paul A. Clark, Cindy L. Zuleger, Amy K. Erbe, Irene M. Ong, Trang Le, Kaitlin Tetreault, Tracy Berg, Alexander L. Rakhmilevich, KyungMann Kim, Michael A. Newton, Mark R. Albertini, Paul M. Sondel, Zachary S. Morris
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113556- (2023)
Summary: We report an in situ vaccination, adaptable to nearly any type of cancer, that combines radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific antibody and interleukin-2 (IL-2; 3xTx). In a phase I clinic
Externí odkaz:
https://doaj.org/article/3b49ec059cc6419f9fcdd7b1869fd235
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often associated with drug resistance. The mechani
Externí odkaz:
https://doaj.org/article/cabddaa252274ddaaa2082008b64a3dc
Autor:
Zijian Ni, Aman Prasad, Shuyang Chen, Richard B. Halberg, Lisa M. Arkin, Beth A. Drolet, Michael A. Newton, Christina Kendziorski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Spatial transcriptomics experiments profile genome-wide gene expression at localized spots across a tissue. Here, the authors identify spot swapping, an artifact where RNA expressed at one tissue spot binds probes at another, and they propose SpotCle
Externí odkaz:
https://doaj.org/article/66cf14fee50f46db8fe773740c41da35
Autor:
Alyssa A. Leystra, Brock J. Gilsdorf, Amanda M. Wisinger, Elise R. Warda, Shanna Wiegand, Christopher D. Zahm, Kristina A. Matkowskyj, Dustin A. Deming, Naghma Khan, Quincy Rosemarie, Chelsie K. Sievers, Alexander R. Schwartz, Dawn M. Albrecht, Linda Clipson, Hasan Mukhtar, Michael A. Newton, Richard B. Halberg
Publikováno v:
Cancer Reports, Vol 5, Iss 2, Pp n/a-n/a (2022)
Abstract Background Data are steadily accruing that demonstrate that intestinal tumors are frequently derived from multiple founding cells, resulting in tumors comprised of distinct ancestral clones that might cooperate or alternatively compete, ther
Externí odkaz:
https://doaj.org/article/8da5b0c5b0914ae6be7061afed01adcb
Autor:
Edgardo Castro-Pérez, Carlos I. Rodríguez, Dareen Mikheil, Shakir Siddique, Alexandra McCarthy, Michael A. Newton, Vijayasaradhi Setaluri
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 177-192 (2019)
Summary: Melanomas are known to exhibit phenotypic plasticity. However, the role cellular plasticity plays in melanoma tumor progression and drug resistance is not fully understood. Here, we used reprogramming of melanocytes and melanoma cells to ind
Externí odkaz:
https://doaj.org/article/6c14c906ae3f4707ac5421fbc805d665
Autor:
Michael A. Newton
Publikováno v:
Bulletin KNOB, Pp 14-19 (1993)
[No summary available]
Externí odkaz:
https://doaj.org/article/6f3ce30b25b74a56ae2fb345819170cd
Autor:
Tiago Bozzola, Mariafrancesca Scalise, Christer U. Larsson, Michael C. Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard E. Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C. J. Dobson, Cesare Indiveri, Jenny Schelin, Ulf J. Nilsson, Ulf Ellervik
Publikováno v:
ACS Chemical Biology. 17:1890-1900
Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic ac
Supplementary Figure S1 from MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
Supplementary Figure S1 presents the viability of SW48 and SW48PK cells after treatment with BEZ235 and TAK-228 at the 100-400nM concentrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3797d51c82d44138bbd5766b7be6a207
https://doi.org/10.1158/1535-7163.22507717.v1
https://doi.org/10.1158/1535-7163.22507717.v1
Autor:
Richard B. Halberg, William R. Schelman, Michael A. Newton, Ruth Sullivan, Linda Clipson, Lauren K. Plesh, Laura A. Nettekoven, Alice Nomura, Dawn M. Albrecht, Christopher D. Zahm, Dustin A. Deming, Alyssa A. Leystra, Chelsie K. Sievers, Jamie N. Hadac, Terrah J. Paul Olson
PDF file - 30K, Relative gene expression is shown for three adenomas and three intramucosal carcinomas taken from the colons of DSS-treated F1 Min mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ba7b91eb0984b007c5cbdb88b39142
https://doi.org/10.1158/1940-6207.22525532
https://doi.org/10.1158/1940-6207.22525532
Autor:
Richard B. Halberg, William R. Schelman, Michael A. Newton, Ruth Sullivan, Linda Clipson, Lauren K. Plesh, Laura A. Nettekoven, Alice Nomura, Dawn M. Albrecht, Christopher D. Zahm, Dustin A. Deming, Alyssa A. Leystra, Chelsie K. Sievers, Jamie N. Hadac, Terrah J. Paul Olson
PDF file - 21K, Characteristics of F1 ApcMin/+ mice treated with 4% dextran sodium sulfate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aec4941d8ab0c4d89817711ec305684
https://doi.org/10.1158/1940-6207.22525529.v1
https://doi.org/10.1158/1940-6207.22525529.v1