Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Michael A. Nash"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Catch bonds are a rare class of protein-protein interactions where the bond lifetime increases under an external pulling force. Here, we report how modification of anchor geometry generates catch bonding behavior for the mechanostable Docker
Externí odkaz:
https://doaj.org/article/ee6d55f38bb9443d821c24403293a281
Autor:
Rosario Vanella, Christoph Küng, Alexandre A. Schoepfer, Vanni Doffini, Jin Ren, Michael A. Nash
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Understanding the complex relationships between enzyme sequence, folding stability and catalytic activity is crucial for applications in industry and biomedicine. However, current enzyme assay technologies are limited by an inability to simu
Externí odkaz:
https://doaj.org/article/557062c21d184b79aad9b20a50a7c08d
Autor:
Joanan Lopez-Morales, Rosario Vanella, Elizabeth A. Appelt, Sarah Whillock, Alexandra M. Paulk, Eric V. Shusta, Benjamin J. Hackel, Chang C. Liu, Michael A. Nash
Publikováno v:
Small Science, Vol 3, Iss 12, Pp n/a-n/a (2023)
Yeast surface display (YSD) is a powerful tool in biotechnology that links genotype to phenotype. In this review, the latest advancements in protein engineering and high‐throughput screening based on YSD are covered. The focus is on innovative meth
Externí odkaz:
https://doaj.org/article/ddae0038718a4776a71f8c164540509e
Autor:
Joanan Lopez-Morales, Rosario Vanella, Tamara Utzinger, Valentin Schittny, Julia Hirsiger, Michael Osthoff, Christoph T. Berger, Yakir Guri, Michael A. Nash
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106648- (2023)
Summary: The emergence of the SARS-CoV-2 Omicron variant altered patient risk profiles and shifted the trajectory of the COVID-19 pandemic. Therefore, sensitive serological tests capable of analyzing patient IgG responses to multiple variants in para
Externí odkaz:
https://doaj.org/article/acba1905787e4d8683cc950f4cf31e66
Autor:
Michael A. Nash
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/0d8fcff7aa694b5ab6007c0d6e56cac8
Publikováno v:
Biophysical Reports, Vol 2, Iss 1, Pp 100035- (2022)
Here, we present a method based on yeast surface display that allows for direct comparison between population-level cell adhesion strength and single-molecule receptor-ligand rupture mechanics. We developed a high-throughput yeast adhesion assay in w
Externí odkaz:
https://doaj.org/article/001372e5b3ae4ec090c892f3ee6a732c
Autor:
Michael A. Nash
Publikováno v:
CHIMIA, Vol 74, Iss 9, Pp 704-709 (2020)
Protein sequences inhabit a discrete set in macromolecular space with incredible capacity to treat human disease. Despite our ability to program and manipulate protein sequences, the vast majority of protein development efforts are still done heurist
Externí odkaz:
https://doaj.org/article/df97287352084a9c881dcc2d7dec8bfe
Autor:
Zhaowei Liu, Haipei Liu, Andrés M. Vera, Rafael C. Bernardi, Philip Tinnefeld, Michael A. Nash
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Understanding bacterial adhesion is important in a number of different areas of study. Here using a range of simulations and experimental methods, the authors, report on the molecular mechanism behind the binding of bacteria to cellulose fibers at hi
Externí odkaz:
https://doaj.org/article/d2e3460e62474fa69f169c914a4432c2
Autor:
Michael A. Nash
Publikováno v:
CHIMIA, Vol 75, Iss 1/2, Pp 64-66 (2021)
The SARS-CoV-2/COVID-19 pandemic has disrupted higher education across the globe. As of early November 2020, Europe now finds itself in the middle of a second wave that is even more destructive than the first. The Swiss Federal Council declared on 28
Externí odkaz:
https://doaj.org/article/5de58da8b7364cac8997e84f3ae09a18
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Single-molecule force spectroscopy with the atomic force microscope provides molecular level insights into protein function, allowing researchers to reconstruct energy landscapes and understand functional mechanisms in biology. With steadily advancin
Externí odkaz:
https://doaj.org/article/046b1dc55e6d4b36aa65c3eb6570f27d