Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael A. Myre"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1210 (2020)
Dictyostelium discoideum is gaining increasing attention as a model organism for the study of calcium binding and calmodulin function in basic biological events as well as human diseases. After a short overview of calcium-binding proteins, the struct
Externí odkaz:
https://doaj.org/article/91b01c1e6b1a431ba259e909ad3a78d6
Publikováno v:
Biological Reviews of the Cambridge Philosophical Society
This review focusses on the functions of intracellular and extracellular calmodulin, its target proteins and their binding proteins during the asexual life cycle of Dictyostelium discoideum. Calmodulin is a primary regulatory protein of calcium signa
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110544 (2014)
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein t
Externí odkaz:
https://doaj.org/article/8e771adcc3de477dbb5616cd9d6d1b81
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1210 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1210 (2020)
Dictyostelium discoideum is gaining increasing attention as a model organism for the study of calcium binding and calmodulin function in basic biological events as well as human diseases. After a short overview of calcium-binding proteins, the struct
Autor:
Michael A Myre, Amanda L Lumsden, Morgan N Thompson, Wilma Wasco, Marcy E MacDonald, James F Gusella
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1002052 (2011)
Huntingtin is a large HEAT repeat protein first identified in humans, where a polyglutamine tract expansion near the amino terminus causes a gain-of-function mechanism that leads to selective neuronal loss in Huntington's disease (HD). Genetic eviden
Externí odkaz:
https://doaj.org/article/9a659ae4b5a640f5a3e9e72400c98aed
Autor:
Hanifa J. Abu Toamih Atamni, Antoine Adamantidis, Eva Adamová, Alejandra I. Aguirre, Vladimir N. Babenko, Maria V. Baez, Jon Beckwith, Douglas M. Bowden, Camron D. Bryant, Jarryd M. Campbell, Karl J. Clark, John C. Crabbe, M. Imad Damaj, Priscila Darakjian, Fernando P.M. De Villena, Mara Dierssen, Evan Dong, Mark F. Dubach, Louis Y. El Khoury, Alberto L. Epstein, Martin T. Ferris, Anna G. Galyamina, Robert T. Gerlai, Terri L. Gilbert, Su Guo, David Hanwell, Christina A. Harrington, Robert Hitzemann, Robert J. Huber, Ovidiu D. Iancu, Fuad A. Iraqi, Diana A. Jerusalinsky, Zhengping Jia, Byron C. Jones, Sulev Kõks, Gea Kõks, Irina L. Kovalenko, Natalia N. Kudryavtseva, Vivek Kumar, Celeste Leung, Peter V. Lovell, Anthony R. McIntosh, Shannon McWeeney, Adam Melgoza, Claudio V. Mello, Megan K. Mulligan, Michael A. Myre, Klotilda Narkaj, Lydia Ng, Danton H. O'Day, Denesa Oberbeck, Ilse S. Pienaar, Robin Pierce, Firyal Ramzan, Petra Ritter, Belén Sancristóbal, David Schlessinger, Cornelia Schöne, Robert Searles, Puneet Sharma, Alexei A. Sharov, Dmitry A. Smagin, Ana Solodkin, Gilda Stefanelli, Leon Stefanovski, Cindy Tao, Ibrahim Tastekin, Joe Z. Tsien, Nikki Walter, Brandon J. Walters, J.T. Westwood, Robert W. Williams, Morgan Wirthlin, Christina Zheng, Joelle Zimmermann, Iva B. Zovkic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d5c23b66ed09edd11b37d8a8f976ea
https://doi.org/10.1016/b978-0-12-804078-2.01002-3
https://doi.org/10.1016/b978-0-12-804078-2.01002-3
Functional Analysis of Proteins Involved in Neurodegeneration Using the Model Organism Dictyostelium
Many neurodegenerative disorders, although related by their destruction of brain function, begin at the cellular level with pathogenic mechanisms that are caused by altered function, expression, or mis-localization of the mutant protein. Understandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514162ea0b53750013a7c3238b3ee433
https://doi.org/10.1016/b978-0-12-804078-2.00021-0
https://doi.org/10.1016/b978-0-12-804078-2.00021-0
Autor:
Amanda Scherer, Michael A. Myre, Deborah Wessels, Daniel F. Lusche, Spencer Kuhl, David R. Soll
Publikováno v:
Developmental Biology. 394:24-38
Huntington׳s disease is a neurodegenerative disorder, attributable to an expanded trinucleotide repeat in the coding region of the human HTT gene, which encodes the protein huntingtin. These mutations lead to huntingtin fragment inclusions in the st
Autor:
Michael A. Myre, Erika Kovács-Bogdán, Molly Plovanich, Kimberli J. Kamer, Ashwini Jambhekar, Vamsi K. Mootha, Michael D. Blower, Yasemin Sancak, Robert J. Huber
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8985-8990
The mitochondrial calcium uniporter is a highly selective calcium channel distributed broadly across eukaryotes but absent in the yeast Saccharomyces cerevisiae. The molecular components of the human uniporter holocomplex (uniplex) have been identifi
Publikováno v:
Journal of Huntington's Disease. 3:261-271
Background: The CAG triplet repeat expansion mutation in the HTT locus, which results in neurodegeneration in Huntington’s disease, elongates a polyglutamine tract in huntingtin, a HEAT/HEAT-like protein that has been highly structurally conserved