Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michael A. Mohutsky"'
Publikováno v:
Molecular Pharmaceutics. 17:3600-3608
Among the FDA-approved small molecule drugs (2005-2016) that are primarily metabolized by cytochrome P450 (CYP), 64% are primarily metabolized by CYP3A4. As the proportion of an individual drug's fraction metabolized through CYP3A4 increases, the ris
Publikováno v:
International Journal of Pharmaceutics. 543:29-37
Amorphous solid dispersions (ASDs) are a promising formulation strategy to increase both the apparent aqueous solubility and bioavailability of poorly water-soluble drugs. Upon dissolution under nonsink conditions, ASDs can generate highly supersatur
Autor:
Jayakumar Surendradoss, Kathleen M. Hillgren, Jiabin Qiu, Anthony Borel, Richard Moulton, Lisa Chen, Jeff Alberts, Cydney M. Martell, Anne Pak, Yingyin Guo, Michael A. Mohutsky, Celia Ochoa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S63-S64
Autor:
Anil Kolur, Yingying Guo, Geri A. Sawada, Andrew T. Hogan, Shelby Hullett, Kathleen M. Hillgren, Bridget L. Morse, Michael A. Mohutsky
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S92-S93
Publikováno v:
Pharmaceutical research. 36(12)
Many bioactive molecules show a type of solution phase behavior, termed promiscuous aggregation, whereby at micromolar concentrations, colloidal drug-rich aggregates are formed in aqueous solution. These aggregates are known to be a major cause of fa
Autor:
Michael A. Mohutsky, Junliang Hao, Xin Zhou, Kenneth C. Cassidy, Loyd R. Hudson, Geri A. Sawada
Publikováno v:
Pharmacology Research & Perspectives
The enterohepatic circulation (EHC) of drugs is often the result of the direct glucuronidation, excretion of the metabolite into bile, followed by hydrolysis to the aglycone by the gut microbiome and finally reabsorption of drug into the systemic cir
Autor:
Donald J. Tweedie, Michael A. Mohutsky, Neil J. Parrott, Sarah Robertson, Diane Ramsden, Niresh Hariparsad, Jane R. Kenny, Conrad Fung
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(10)
A recent publication from the Innovation and Quality Consortium Induction Working Group collated a large clinical data set with the goal of evaluating the accuracy of drug-drug interaction (DDI) prediction from in vitro data. Somewhat surprisingly, c
Publikováno v:
Drug Metabolism and Disposition. 44:1819-1827
Surrogate assays for drug metabolism and inhibition are traditionally performed in buffer systems at pH 7.4, despite evidence that hepatocyte intracellular pH is 7.0. This pH gradient can result in a pKa-dependent change in intracellular/extracellula
Autor:
David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou
Publikováno v:
Drug Metabolism and Disposition. 44:1184-1192
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity a
Autor:
Kathleen M. Hillgren, David W. Bedwell, Bridget L. Morse, Norikazu Matsunaga, Aleksandra Galetin, Michael A. Mohutsky, J. Brian Houston, Stephen D. Hall, Jingqi Bao, Ayşe Ufuk
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(3)
In the present study, the beagle dog was evaluated as a preclinical model to investigate organic anion transporting polypeptide (OATP)-mediated hepatic clearance. In vitro studies were performed with nine OATP substrates in three lots of plated male