Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Michael A. Mccabe"'
Autor:
Alex Y. Ge, Abolfazl Arab, Raymond Dai, Albertas Navickas, Lisa Fish, Kristle Garcia, Hosseinali Asgharian, Jackson Goudreau, Sean Lee, Kathryn Keenan, Melissa B. Pappalardi, Michael T. McCabe, Laralynne Przybyla, Hani Goodarzi, Luke A. Gilbert
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The search for new approaches in cancer therapy requires a mechanistic understanding of cancer vulnerabilities and anti-cancer drug mechanisms of action. Problematically, some effective therapeutics target cancer vulnerabilities that have po
Externí odkaz:
https://doaj.org/article/502044bc11f6478ab5fb48123fb6c155
Autor:
Georgios Vlasakakis, Michael T. McCabe, Yu Liu Ho, Geraldine Ferron‐Brady, Paul Martin, Darren Bentley, Catherine Ellis, Mary Antonysamy, Sandra A. G. Visser
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Myelofibrosis is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, splenomegaly, anemia, and constitutional symptoms, with a median survival of ≈6 years from diagnosis. While currently approved Janus kinase (JAK)
Externí odkaz:
https://doaj.org/article/007db636c4c9495b90b6e087de2b9aef
Autor:
Ashley K. Wiseman, Rochelle L. Tiedemann, Huihui Fan, Hui Shen, Zachary Madaj, Michael T. McCabe, Melissa B. Pappalardi, Peter A. Jones
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Chromosome specific retention of cancer associated DNA hypermethylation following pharmacological inhibition of DNMT1 is shown, with residual CpG methylation on the X chromosome compared to autosomes, suggesting a separate mechanism of methylation.
Externí odkaz:
https://doaj.org/article/f61392dc449b4ea58f124af35530403b
Autor:
Jiajia Dai, Hyangin Kim, Zerong You, Michael F. McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Mao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon. In thr
Externí odkaz:
https://doaj.org/article/de864ada10de4337b218cde94cab6a09
Autor:
Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2
Externí odkaz:
https://doaj.org/article/375cf7300ce44f4d81582faca63eef19
Autor:
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD
Externí odkaz:
https://doaj.org/article/bb08125c1aa14689b48e6b606c7f9587
Autor:
Ping Chi, Yu Chen, Deyou Zheng, Cristina R. Antonescu, Jacob L. Glass, Richard P. Koche, Joseph M. Scandura, Sarat Chandarlapaty, Charles M. Rudin, Jonathan A. Fletcher, Michael T. McCabe, Melissa B. Pappalardi, Emily Giff, Juan Yan, Elissa W.P. Wong, Yinuo Meng, Eve Fishinevich, Gabriella Bayshtok, Naitao Wang, Dan Li, Cindy J. Lee, Mohini R. Pachai, Miguel A. Miranda-Román, Rohan Misra, Jesper L.V. Maag, Sarah Warda, Amish J. Patel
Supplementary Data from PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f847d5ee315f0b1a992e649f77a1c97
https://doi.org/10.1158/2159-8290.22540900.v1
https://doi.org/10.1158/2159-8290.22540900.v1
Autor:
Ping Chi, Yu Chen, Deyou Zheng, Cristina R. Antonescu, Jacob L. Glass, Richard P. Koche, Joseph M. Scandura, Sarat Chandarlapaty, Charles M. Rudin, Jonathan A. Fletcher, Michael T. McCabe, Melissa B. Pappalardi, Emily Giff, Juan Yan, Elissa W.P. Wong, Yinuo Meng, Eve Fishinevich, Gabriella Bayshtok, Naitao Wang, Dan Li, Cindy J. Lee, Mohini R. Pachai, Miguel A. Miranda-Román, Rohan Misra, Jesper L.V. Maag, Sarah Warda, Amish J. Patel
Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent cancers, but an unmet therapeutic need exists in PRC2-loss cancer. PRC2-inactivating mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddd2212905d2044de7e4a7a9f01b27a
https://doi.org/10.1158/2159-8290.c.6549502.v1
https://doi.org/10.1158/2159-8290.c.6549502.v1
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Figure 1: Standard curves of recombinant modified histone proteins for quantification of western blots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b70fab24cd9253c9bdf762690f23cd
https://doi.org/10.1158/1535-7163.22502863
https://doi.org/10.1158/1535-7163.22502863
Supplementary Figures S1-S3 and Supplementary Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c062d98638b4d0392905dc3ac9207ae
https://doi.org/10.1158/1541-7786.22519248.v1
https://doi.org/10.1158/1541-7786.22519248.v1