Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michael A. McIlhatton"'
Autor:
Joanna Groden, Carlo M. Croce, Gregory P. Boivin, Daniel Carson, Kevin Murnan, Michael A. McIlhatton
Although disruption of DNA repair capacity is unquestionably associated with cancer susceptibility in humans and model organisms, it remains unclear if the inherent tumor phenotypes of DNA repair deficiency syndromes can be regulated by manipulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3984e8ad2349f081696e54fe7582323f
https://doi.org/10.1158/1940-6207.c.6544584
https://doi.org/10.1158/1940-6207.c.6544584
Autor:
Joanna Groden, Carlo M. Croce, Gregory P. Boivin, Daniel Carson, Kevin Murnan, Michael A. McIlhatton
Supplementary Figure S1. qPCR discriminates between mice hemizygous and homozygous for the BLM-Tg.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc57261f2468f701629f4e37339dcbb1
https://doi.org/10.1158/1940-6207.22525122.v1
https://doi.org/10.1158/1940-6207.22525122.v1
Autor:
Joanna Groden, Kun Huang, Guy N. Brock, Jie Zhang, Baris Hancioglu, Brian Kennedy, Kenechi Ebede, Michael A. McIlhatton, William Hankey
Predictive Value for Candidate Genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d19473bb24b677fb700b98e1367128d
https://doi.org/10.1158/0008-5472.22417454.v1
https://doi.org/10.1158/0008-5472.22417454.v1
Autor:
Joanna Groden, Kun Huang, Guy N. Brock, Jie Zhang, Baris Hancioglu, Brian Kennedy, Kenechi Ebede, Michael A. McIlhatton, William Hankey
APC biallelic loss-of-function mutations are the most prevalent genetic changes in colorectal tumors, but it is unknown whether these mutations phenocopy gain-of-function mutations in the CTNNB1 gene encoding β-catenin that also activate canonical W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cf5e8432cf1ade85e1a212dd826ac2
https://doi.org/10.1158/0008-5472.c.6509849
https://doi.org/10.1158/0008-5472.c.6509849
Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients
Autor:
Kenechi Ebede, Jie Zhang, Michael A. McIlhatton, William Hankey, Brian K. Kennedy, Joanna Groden, Baris Hancioglu, Guy Brock, Kun Huang
Publikováno v:
Cancer Research. 78:617-630
APC biallelic loss-of-function mutations are the most prevalent genetic changes in colorectal tumors, but it is unknown whether these mutations phenocopy gain-of-function mutations in the CTNNB1 gene encoding β-catenin that also activate canonical W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20229e376037882bd68463b3613087e4
https://doi.org/10.1158/0008-5472.can-17-1357
https://doi.org/10.1158/0008-5472.can-17-1357
Publikováno v:
BioMed Research International, Vol 2016 (2016)
BioMed Research International
BioMed Research International
Technical and biological innovations have enabled the development of more sophisticated and focused murine models that increasingly recapitulate the complex pathologies of human diseases, in particular cancer. Mouse models provide excellentin vivosys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39109c7f5fb87f81096d73ef1a7cbec6
https://doi.org/10.1155/2016/1414383
https://doi.org/10.1155/2016/1414383
Autor:
Gregory P. Boivin, Michael A. McIlhatton, Carlo M. Croce, Kevin Murnan, Joanna Groden, Daniel J. Carson
Publikováno v:
Cancer Prevention Research. 8:650-656
Although disruption of DNA repair capacity is unquestionably associated with cancer susceptibility in humans and model organisms, it remains unclear if the inherent tumor phenotypes of DNA repair deficiency syndromes can be regulated by manipulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390e643c9c130f9da7281c971a7b8086
https://doi.org/10.1158/1940-6207.capr-15-0001-t
https://doi.org/10.1158/1940-6207.capr-15-0001-t
Publikováno v:
Genes, Vol 7, Iss 9, p 69 (2016)
Genes
Genes; Volume 7; Issue 9; Pages: 69
Genes
Genes; Volume 7; Issue 9; Pages: 69
Defects in coordinated ribosomal RNA (rRNA) transcription in the nucleolus cause cellular and organismal growth deficiencies. Bloom’s syndrome, an autosomal recessive human disorder caused by mutated recQ-like helicase BLM, presents with growth def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064d5b7cec423b1ae7487e1e6be951ee
http://www.mdpi.com/2073-4425/7/9/69
http://www.mdpi.com/2073-4425/7/9/69
Publikováno v:
Cancer Research. 78:PR08-PR08
Bloom's syndrome (BS) is a recessive human chromosome breakage disorder caused by mutations in the recQ-like helicase BLM, sometimes known as RECQL2. Its clinical phenotype invariably includes male infertility, dwarfism, cancer susceptibility, and gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24271043536cf49e120111ff4fcdec7f
https://doi.org/10.1158/1538-7445.mousemodels17-pr08
https://doi.org/10.1158/1538-7445.mousemodels17-pr08
Autor:
Pierluigi Gasparini, Manuela Ferracin, Francesca Fanini, Angelo Veronese, Stefano Volinia, Massimo Negrini, Muller Fabbri, Stefan Costinean, Roberta Gafà, Brett Adair, Michael A. McIlhatton, Sukhinder K. Sandhu, Francesca Lovat, Chiara Braconi, Federica Calore, Ivan Vannini, Arianna Bottoni, Giovanni Lanza, Richard Fishel, Nicola Valeri, Carlo M. Croce, Gerard J. Nuovo, Hansjuerg Alder, Dino Amadori
Publikováno v:
Proceedings of the National Academy of Sciences. 107:6982-6987
Inactivation of mismatch repair (MMR) is the cause of the common cancer predisposition disorder Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), as well as 10–40% of sporadic colorectal, endometrial, ovarian, ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd8adb3b3d131beccdc42e03b82f86d
https://doi.org/10.1073/pnas.1002472107
https://doi.org/10.1073/pnas.1002472107