Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Michael A. McGregor"'
Autor:
Ujjwal Rathore, Paige Haas, Vigneshwari Easwar Kumar, Joseph Hiatt, Kelsey M. Haas, Mehdi Bouhaddou, Danielle L. Swaney, Erica Stevenson, Lorena Zuliani-Alvarez, Michael J. McGregor, Autumn Turner-Groth, Charles Ochieng' Olwal, Yaw Bediako, Hannes Braberg, Margaret Soucheray, Melanie Ott, Manon Eckhardt, Judd F. Hultquist, Alexander Marson, Robyn M. Kaake, Nevan J. Krogan
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTDuring HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3 ubiquitin ligases is not well understood. Proteomics analyses identified 116 single-
Externí odkaz:
https://doaj.org/article/a68bf9f80cd74600b676bdd895184026
Autor:
Kelsey M. Haas, Michael J. McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun-Young Kim, Thong T. Nguyen, Billy W. Newton, Matthew Urbanowski, Heejin Kim, Michael A. P. Williams, Veronica V. Rezelj, Alexandra Hardy, Andrea Fossati, Erica J. Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A. Tummino, James E. Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S. Jureka, Christopher F. Basler, Kevan M. Shokat, Brian K. Shoichet, Leah P. Shriver, Jeffrey R. Johnson, Megan L. Shaw, Sumit K. Chanda, Dan M. Roden, Tonia C. Carter, Leah C. Kottyan, Rex L. Chisholm, Jennifer A. Pacheco, Maureen E. Smith, Steven J. Schrodi, Randy A. Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L. Swaney, Manon Eckhardt, Steven M. Wolinsky, Kris M. White, Judd F. Hultquist, Robyn M. Kaake, Adolfo García-Sastre, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using aff
Externí odkaz:
https://doaj.org/article/6403bbe7a8b6480aacd27d46627e36f2
Autor:
Joseph Hiatt, Judd F. Hultquist, Michael J. McGregor, Mehdi Bouhaddou, Ryan T. Leenay, Lacy M. Simons, Janet M. Young, Paige Haas, Theodore L. Roth, Victoria Tobin, Jason A. Wojcechowskyj, Jonathan M. Woo, Ujjwal Rathore, Devin A. Cavero, Eric Shifrut, Thong T. Nguyen, Kelsey M. Haas, Harmit S. Malik, Jennifer A. Doudna, Andrew P. May, Alexander Marson, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.
Externí odkaz:
https://doaj.org/article/4afe586db1e74b9e9e49556512d17fd5
Autor:
Yushen Du, Judd F. Hultquist, Quan Zhou, Anders Olson, Yenwen Tseng, Tian-hao Zhang, Mengying Hong, Kejun Tang, Liubo Chen, Xiangzhi Meng, Michael J. McGregor, Lei Dai, Danyang Gong, Laura Martin-Sancho, Sumit Chanda, Xinming Li, Steve Bensenger, Nevan J. Krogan, Ren Sun
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A viru
Externí odkaz:
https://doaj.org/article/6e0ba4fb71cb4e7ea04eed81d78d3f6a
Autor:
Judd F. Hultquist, Kathrin Schumann, Jonathan M. Woo, Lara Manganaro, Michael J. McGregor, Jennifer Doudna, Viviana Simon, Nevan J. Krogan, Alexander Marson
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1438-1452 (2016)
Summary: New genetic tools are needed to understand the functional interactions between HIV and human host factors in primary cells. We recently developed a method to edit the genome of primary CD4+ T cells by electroporation of CRISPR/Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/c5e4f90fd3b349c0bf28cdd2cec6c482
Publikováno v:
European Policy Analysis. 8:370-393
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ed427d14d6dbb5d1eb1a4faceff64b
https://doi.org/10.1002/epa2.1139
https://doi.org/10.1002/epa2.1139
Autor:
Jennifer M Binning, Amber M Smith, Judd F Hultquist, Charles S Craik, Nathalie Caretta Cartozo, Melody G Campbell, Lily Burton, Florencia La Greca, Michael J McGregor, Hai M Ta, Koen Bartholomeeusen, B Matija Peterlin, Nevan J Krogan, Natalia Sevillano, Yifan Cheng, John D Gross
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006830 (2018)
The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection. Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by re
Externí odkaz:
https://doaj.org/article/7095456598e14d2cb94a7e382671d584
Autor:
Courtney Nguyen, Danielle L. Swaney, Lars Pache, Hong M. Moulton, David A. Stein, Shashank Tripathi, Dexter Pratt, Trey Ideker, Stephen Soonthornvacharin, David Jimenez-Morales, Maite Sanchez-Aparicio, Nish Beltran-Raygoza, Paul D. De Jesus, Randy A. Albrecht, Kelsey M. Haas, Adolfo García-Sastre, Judd F. Hultquist, João I. Mamede, Guojun Wang, Laura Martin-Sancho, Ariel Rodriguez-Frandsen, Christopher Churas, Max W. Chang, Sara Brin Rosenthal, Thong T. Nguyen, Nevan J. Krogan, Sumit K. Chanda, Michael J. McGregor, Laura Riva, Christopher Benner
Publikováno v:
Nature microbiology, vol 6, iss 10
Nat Microbiol
Nat Microbiol
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and viral evasion strategies. To illuminate the landscape of IAV cellular restriction, we generated and integrated global geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b8b7933cc7d6e1aee1e78f2f5ec156
https://doi.org/10.1038/s41564-021-00964-2
https://doi.org/10.1038/s41564-021-00964-2
Autor:
J. Silvio Gutkind, Rachel A. O'Keefe, Jason F. Kreisberg, Jisoo Park, Dana J. Ramms, David Jimenez-Morales, Trey Ideker, Danielle L. Swaney, Helene Foussard, Fan Zheng, Michael J. McGregor, Jennifer R. Grandis, Kari A. Herrington, Natalia Jura, Yusuke Goto, Nan Jin, Mehdi Bouhaddou, Yan Zeng, Kyumin Kim, Margaret Soucheray, Daniel Johnson, Zhiyong Wang, Nevan J. Krogan, Min-Kyu Kim, John Von Dollen, Kirsten Obernier, Neil E. Bhola, Nathan K. VanLandingham
Publikováno v:
Science (New York, N.Y.), vol 374, iss 6563
Science
Science
Mapping protein interactions driving cancer Cancer is a genetic disease, and much cancer research is focused on identifying carcinogenic mutations and determining how they relate to disease progression. Three papers demonstrate how mutations are proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a275fcfba104564e2a5218ab9c04ad
https://doi.org/10.1126/science.abf2911
https://doi.org/10.1126/science.abf2911
Autor:
Danielle L. Swaney, Kuei Ho Chen, Alan Ashworth, Morgan E. Diolaiti, Trey Ideker, Fan Zheng, Bing Xia, Kari A. Herrington, Beril Tutuncuoglu, Michael J. McGregor, John D. Gordan, Min-Kyu Kim, Mehdi Bouhaddou, Denise P. Muñoz, Denise M. Wolf, Erica Stevenson, Nevan J. Krogan, Margaret Soucheray, Tzeh Keong Foo, Patrick O’Leary, Ajda Rojc, Maya Modak, Kyumin Kim, Laura van 't Veer, Jean-Philippe Coppe, Jason F. Kreisberg, Jisoo Park, Dominique C. Mitchell
Publikováno v:
Science
Science (New York, N.Y.), vol 374, iss 6563
Science (New York, N.Y.), vol 374, iss 6563
Mapping protein interactions driving cancer Cancer is a genetic disease, and much cancer research is focused on identifying carcinogenic mutations and determining how they relate to disease progression. Three papers demonstrate how mutations are proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ba5ac99a6a028e92c535730897988
https://europepmc.org/articles/PMC9040556/
https://europepmc.org/articles/PMC9040556/
