Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael A. Matchett"'
Autor:
Bill Bingenheimer, Hong Jun-Bae, Qingwu Jin, Michael Welch, Michael Allen Matchett, Erin M. O'brien, James Edward Paul Davidson, Keshab Sarma, Gary R. Lee
Publikováno v:
Organic Process Research & Development. 18:228-238
A scalable and convergent synthesis of a BTK (Bruton’s tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for the scale-up campaign, especially the process for 6-dimethylaminodihydroisoquinolinone, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1027a98be9ddbbb804a8972b8541c1
https://doi.org/10.1021/op4001077
https://doi.org/10.1021/op4001077
Autor:
Michael D. Matchett, Miwako Kondo, Shawna L. MacKinnon, Catherine C. Neto, Cheryl C Craft, Robert A. R. Hurta
Publikováno v:
Journal of the Science of Food and Agriculture. 91:789-796
BACKGROUND: Ursolic acid and its cis- and trans-3-O-p-hydroxycinnamoyl esters have been identified as constituents of American cranberries (Vaccinium macrocarpon), which inhibit tumor cell proliferation. Since the compounds may contribute to berry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c01772f635fc5f239bfc06a617c3a032
https://doi.org/10.1002/jsfa.4330
https://doi.org/10.1002/jsfa.4330
Autor:
Terrence J. Connolly, Jiang Zhu, Michael Allen Matchett, Sunil Sukhtankar, Patrick Finbar Mcgarry
Publikováno v:
Organic Process Research & Development. 10:391-397
An efficient synthesis of an adrenoceptor antagonist has been developed and demonstrated in a pilot plant. A linear synthesis that relied on a catalytic reduction of a rather insoluble nitroaromatic proved to be a viable route. The active pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d428495d6fe1f02b0b34ac8e527dc6c
https://doi.org/10.1021/op050122h
https://doi.org/10.1021/op050122h
Autor:
Terrence J. Connolly, Constantinescue Anton, Michael Allen Matchett, Tim S. Lane, Mariya Paperna, and Patrick McGarry
Publikováno v:
Organic Process Research & Development. 9:837-842
During the development of a sodium borohydride mediated reductive amination of 3-nitrobenzaldehyde with methylamine, studies revealed that partial reduction of the nitro group occurred, and potentially dangerous azo- and azoxy-containing products wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9befcd5b464a34878ab6aca133149a6
https://doi.org/10.1021/op050120x
https://doi.org/10.1021/op050120x
Autor:
Katherine Gottschall-Pass, Shawna L. MacKinnon, Michael D. Matchett, Robert A. R. Hurta, Marva I. Sweeney
Publikováno v:
Biochemistry and Cell Biology. 83:637-643
Regulation of the matrix metalloproteinases (MMPs), the major mediators of extracellular matrix (ECM) degradation, is crucial to regulate ECM proteolysis, which is important in metastasis. This study examined the effects of 3 flavonoid-enriched fract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffaa6009e52d47449fcf7934f5a22906
https://doi.org/10.1139/o05-063
https://doi.org/10.1139/o05-063
Autor:
Abraham Vaisberg, Jess D. Reed, Robert A. R. Hurta, Toni L. Lamoureaux, Marva I. Sweeney, Horace Yeung, Shannon Curtis, Michael D. Matchett, Catherine C. Neto, Miwako Kondo, Christian G. Krueger
Publikováno v:
Journal of the Science of Food and Agriculture. 86:18-25
Proanthocyanidin-rich extracts were prepared by fractionation of the fruit of the North American cranberry (Vaccinium macrocarpon). In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions inhibited the growth of H46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34f45ddb7a7cc92c42690506d1dfe498
https://doi.org/10.1002/jsfa.2347
https://doi.org/10.1002/jsfa.2347
Publikováno v:
Organic Process Research & Development. 9:80-87
A synthetic route to a potent and selective α-1-adrenergic receptor antagonist has been developed and demonstrated in a pilot plant. The route has been used in two pilot plant campaigns and has produced RO3203546 in 2.3 and 12.0 kg batch sizes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9efd82e1372f2c8994190690bc8377dd
https://doi.org/10.1021/op0498114
https://doi.org/10.1021/op0498114
Autor:
Terrence J. Connolly, Jiang Zhu, and Sunil Sukhtankar, Patrick Finbar Mcgarry, Michael Allen Matchett
Publikováno v:
Organic Process Research & Development. 8:624-627
A streamlined, telescoped process has been developed for the preparation of 3,4-dimethoxy-o-toluic acid, starting with economical and readily available 2,3-dimethoxybenzaldehyde. Catalytic reduction of the aldehyde functional group generated dimethox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eee22177c1d252a75fe152208df689e
https://doi.org/10.1021/op049938t
https://doi.org/10.1021/op049938t
Publikováno v:
Inorganic Chemistry. 33:1109-1114
The disilylphosphido complexes M[P(SiPh 3 ) 2 ] 2 , where M=Zn, Cd, Hg, and Sn, are prepared in 50-90% yields and isolated as crystalline solids or powders. Cryoscopic and NMR data indicate that the compounds are monomers in solution. The solid-state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39be2c501826e5c522b3763d5633a1d8
https://doi.org/10.1021/ic00084a023
https://doi.org/10.1021/ic00084a023
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 76:289-292
Several homoleptic disilylphosphido complexes are described, which are relatives of the well-known homoleptic disilylamido complexes. The differing properties of the amido and phosphido ligands are ascribed to normal periodic relationships.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc91ed3cc7e6bec2a0835a3932c0fafa
https://doi.org/10.1080/10426509308032415
https://doi.org/10.1080/10426509308032415