Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michael A. Lodato"'
Autor:
Jenny Lai, Didem Demirbas, Junho Kim, Ailsa M. Jeffries, Allie Tolles, Junseok Park, Thomas W. Chittenden, Patrick G. Buckley, Timothy W. Yu, Michael A. Lodato, Eunjung Alice Lee
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113622- (2024)
Summary: While ATM loss of function has long been identified as the genetic cause of ataxia-telangiectasia (A-T), how it leads to selective and progressive degeneration of cerebellar Purkinje and granule neurons remains unclear. ATM expression is enr
Externí odkaz:
https://doaj.org/article/bb2b0c8299d2444ab13e02b7f0a6bb28
Autor:
Junho Kim, August Yue Huang, Shelby L. Johnson, Jenny Lai, Laura Isacco, Ailsa M. Jeffries, Michael B. Miller, Michael A. Lodato, Christopher A. Walsh, Eunjung Alice Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
DNA damage has been implicated in aging and neurodegeneration. Here, the authors develop a bioinformatic method to detect deletions in single neuron genome sequences and reveal an increased burden of somatic deletions during aging and in DNA repair d
Externí odkaz:
https://doaj.org/article/162ddeb312a542bf86be9477a455f1cc
Autor:
Michael A. Lodato, Jan Vijg
Publikováno v:
Frontiers in Aging, Vol 3 (2023)
Externí odkaz:
https://doaj.org/article/89a35511749f4176a785959ec321db1f
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Maintaining genomic integrity in post-mitotic neurons in the human brain is paramount because these cells must survive for an individual’s entire lifespan. Due to life-long synaptic plasticity and electrochemical transmission between cells, the bra
Externí odkaz:
https://doaj.org/article/aabebdac64b54c9ca16cffed2541e396
Autor:
Sangita Choudhury, August Yue Huang, Junho Kim, Zinan Zhou, Katherine Morillo, Eduardo A. Maury, Jessica W. Tsai, Michael B. Miller, Michael A. Lodato, Sarah Araten, Nazia Hilal, Eunjung Alice Lee, Ming Hui Chen, Christopher A. Walsh
Publikováno v:
Nature Aging. 2:714-725
The accumulation of somatic DNA mutations over time is a hallmark of aging in many dividing and nondividing cells but has not been studied in postmitotic human cardiomyocytes. Using single-cell whole-genome sequencing, we identified and characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31bdf78d75e273ff9d5821a56da4178
https://doi.org/10.1038/s43587-022-00261-5
https://doi.org/10.1038/s43587-022-00261-5
Autor:
Michael B. Miller, August Yue Huang, Junho Kim, Zinan Zhou, Samantha L. Kirkham, Eduardo A. Maury, Jennifer S. Ziegenfuss, Hannah C. Reed, Jennifer E. Neil, Lariza Rento, Steven C. Ryu, Chanthia C. Ma, Lovelace J. Luquette, Heather M. Ames, Derek H. Oakley, Matthew P. Frosch, Bradley T. Hyman, Michael A. Lodato, Eunjung Alice Lee, Christopher A. Walsh
Publikováno v:
Nature
Dementia in Alzheimer’s disease progresses alongside neurodegeneration(1–4), but the specific events that cause neuronal dysfunction and death remain poorly understood. During normal ageing, neurons progressively accumulate somatic mutations(5) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1655e9b7142b4e460d87e561c9b1d5d
https://doi.org/10.1038/s41586-022-04640-1
https://doi.org/10.1038/s41586-022-04640-1
Autor:
Lovelace J. Luquette, Michael B. Miller, Zinan Zhou, Craig L. Bohrson, Yifan Zhao, Hu Jin, Doga Gulhan, Javier Ganz, Sara Bizzotto, Samantha Kirkham, Tino Hochepied, Claude Libert, Alon Galor, Junho Kim, Michael A. Lodato, Juan I. Garaycoechea, Charles Gawad, Jay West, Christopher A. Walsh, Peter J. Park
Publikováno v:
Nature Genetics, 54(10), 1564-1571. Nature Publishing Group
NATURE GENETICS
Nat Genet
NATURE GENETICS
Nat Genet
Single-cell DNA sequencing data are generated from human neurons using primary template-directed amplification and analyzed using SCAN2, an improved genotyping tool. Indels are enriched in neuronal regulatory elements and may be deleterious. Accurate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbfb2ab572d96cf2841204754caaf5d
https://pure.knaw.nl/portal/en/publications/c32b40db-e719-45a1-8319-adee9a8a4292
https://pure.knaw.nl/portal/en/publications/c32b40db-e719-45a1-8319-adee9a8a4292
Autor:
Julie Bourseguin, Wen Cheng, Emily Talbot, Liana Hardy, Jenny Lai, Ailsa M Jeffries, Michael A Lodato, Eunjung Alice Lee, Svetlana V Khoronenkova
Funder: Charles H. Hood Child Health Foundation
Funder: Wellcome Trust ISSF
Funder: CRUK Cambridge Centre
Funder: AstraZeneca PhD studentship
Funder: Suh Kyungbae Foundation
Funder: University of Cambridge Joint Research Gran
Funder: Wellcome Trust ISSF
Funder: CRUK Cambridge Centre
Funder: AstraZeneca PhD studentship
Funder: Suh Kyungbae Foundation
Funder: University of Cambridge Joint Research Gran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636af4243e962aab073a5f416cab5801
Autor:
Boxun Zhao, Junho Kim, Michael B. Miller, Christopher A. Walsh, Eunjung Lee, Michael A. Lodato, August Yue Huang
Publikováno v:
Nature. 584:E20-E28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c198e59e76937cc447d737e2090aa98
https://doi.org/10.1038/s41586-020-2522-3
https://doi.org/10.1038/s41586-020-2522-3
Autor:
Junho Kim, Jenny Lai, Timothy W. Yu, Allie Tolles, Michael A. Lodato, Ailsa M. Jeffries, Eunjung Lee, Patrick G. Buckley, Thomas Chittenden
While ATM loss-of-function has long been identified as the genetic cause of Ataxia Telangiectasia (AT), how this genetic mutation leads to selective and progressive cerebellar degeneration of Purkinje and granule cells remains unknown. We performed s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63d3630784c20c9126d9f233ea52f95
https://doi.org/10.1101/2021.09.09.459619
https://doi.org/10.1101/2021.09.09.459619