Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael A. Leesnitzer"'
Autor:
Jeffery L. Smith, Anikó M. Redman, Robert A. Mook, Bin Yang, Felix Deanda, Joseph W. Wilson, J.B Shotwell, Roseanne Gerding, Stanley D. Chamberlain, Lisa M. Shewchuk, Huangshu Lei, Michael A. Leesnitzer, Samarjit Patnaik, Peter Sabbatini, Arthur Groy, Jason L. Rowand, Charity Atkins, Rakesh Kumar, Ganesh S. Moorthy, Kirk L. Stevens, A.M. Hassell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:360-364
The SAR of C5′ functional groups with terminal basic amines at the C6 aniline of 4,6-bis-anilino-1 H -pyrrolo[2,3- d ]pyrimidines is reported. Examples demonstrate potent inhibition of IGF-1R with 1000-fold selectivity over JNK1 and 3 in enzymatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee84f30be2cd8cafb0fa1bbaf2738997
https://doi.org/10.1016/j.bmcl.2008.11.077
https://doi.org/10.1016/j.bmcl.2008.11.077
Autor:
Jeffrey A. Stafford, Alan B Strickland, D. Rose, Paul L. Domanico, Michael A. Leesnitzer, David J. Cowan, Rayomand J. Unwalla, Stephen A. Stimpson, Paul L. Feldman, Nicole L. Valvano, E Sloan Brawley, Margrith W. Verghese
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1977-1982
Structure-activity relationships within a series of 1,3,4-trisubstituted pyrrolidines, novel and selective inhibitors of cAMP-specific phosphodiesterase (PDE IV), are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::893869299605435f076797071dd38d5a
https://doi.org/10.1016/0960-894x(95)00336-r
https://doi.org/10.1016/0960-894x(95)00336-r
Autor:
Jeffrey A. Stafford, Rayomand J. Unwalla, Frank J. Schoenen, Paul L. Feldman, Brian Edward Marron, Paul L. Domanico, Nicole L. Valvano, E Sloan Brawley, D. Rose, Michael A. Leesnitzer, Robert W. Dougherty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1855-1860
Structure-activity relationships involving the aromatic ring of the selective PDE IV inhibitor, rolipram (1), are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434517a9cfbdef484098489732be5545
https://doi.org/10.1016/s0960-894x(01)80384-x
https://doi.org/10.1016/s0960-894x(01)80384-x
Autor:
James Michael Salovich, Gary K. Smith, C.W. Andrews, Kevin Wayne Kuntz, Timothy J. Lansing, Mui Cheung, Michael A. Leesnitzer, Mark Andrew Pobanz, Daniel F. Hassler, Jeffery L. Smith, Andrea H. Epperly, Lisa M. Shewchuk, Robert A. Mook, Brian Wilson
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472e99ce576cce16ad1025e54eae0f89
https://pubmed.ncbi.nlm.nih.gov/18929484
https://pubmed.ncbi.nlm.nih.gov/18929484
Publikováno v:
Biochimica et biophysica acta. 1069(2)
We report here the first experimentally determined lateral diffusion coefficients of the F1F0-ATP synthase and the ADP/ATP translocator in isolated inner membranes of rat liver mitochondria. Rabbit IgG developed against the F1F0-ATP synthase isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa147b0792ac790ef35806caf987a45
https://pubmed.ncbi.nlm.nih.gov/1718429
https://pubmed.ncbi.nlm.nih.gov/1718429