Výsledky vyhledávání - "Michael A. Landau"

Impact of molecular testing on detecting mimics of oncocytic neoplasms in thyroid fine‐needle aspirates diagnosed as follicular neoplasm of Hürthle cell (oncocytic) type

Autor: Michael S. Landau, Simion I. Chiosea, N. Paul Ohori, Yuri E. Nikiforov

Publikováno v: Cancer Cytopathology. 129:788-797

Background Some thyroid nodules cytologically presenting as follicular neoplasm, Hurthle cell (Oncocytic) type (FNHCT), are not oncocytic tumors and represent autonomously functioning thyroid nodules (AFTNs) with TSHR, GNAS, and EZH1 mutations or onc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e409017467a92f2e10f124e57fe30d
https://doi.org/10.1002/cncy.22439

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Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma

Autor: Simion I. Chiosea, John M Skaugen, Raja R. Seethala, Michael S. Landau

Publikováno v: Cancer Cytopathology. 129:104-113

Background Acinic cell carcinoma (AcCC) is diagnostically challenging on fine-needle aspiration because it can mimic several other neoplasms or even normal acinar tissue. Immunopositivity for DOG1, especially circumferential membranous staining, can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a30c44e7482135bf5d6f11065c577a3
https://doi.org/10.1002/cncy.22338

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Thyroid cytology smear slides: An untapped resource for ThyroSeq testing

Autor: Cihan Kaya, Claudio Bellevicine, Umberto Malapelle, Marina N. Nikiforova, Giancarlo Troncone, Megan E. Miller, Yuri E. Nikiforov, Zubair W. Baloch, N. Paul Ohori, Lindsey A. Tolino, Marcos Lepe, Abigail I. Wald, Michael S. Landau

Publikováno v: Cancer Cytopathology. 129:33-42

Background Molecular testing of thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology is commonly used to guide patient management and is typically performed on freshly collected FNA samples. In this study, the authors evaluated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b817511ad6f5fa73b9e40ee0a940d6
https://doi.org/10.1002/cncy.22331

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Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab

Autor: Michael S. Landau, Sigfred Lajara

Publikováno v: Diagnostic cytopathologyREFERENCES. 49(9)

Malignant melanoma is a well-known diagnostic pitfall, given its propensity to metastasize to different sites and mimic various entities. In this report, we present a fine-needle aspiration biopsy (FNA) of a metastatic melanoma with basaloid features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4cf0a5ce7e1357e82516ed6ade17ab
https://pubmed.ncbi.nlm.nih.gov/34174024

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Molecular alterations in Hürthle cell nodules and preoperative cancer risk

Autor: Simion I. Chiosea, William R Doerfler, Michael S. Landau, Linwah Yip, Alyaksandr V. Nikitski, N. Paul Ohori, Pooja Manroa, Elena M. Morariu, Marina N. Nikiforova, Yuri E. Nikiforov

Publikováno v: Endocrine-related cancer. 28(5)

Hürthle cell carcinoma (HCC) is a distinct type of thyroid cancer genetically characterized by DNA copy number alterations (CNA), typically of genome haploidization type (GH-type). However, whether CNA also occurs in benign Hürthle cell adenomas (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3990f9e4b0fdcc96b4bcaeb4419609
https://pubmed.ncbi.nlm.nih.gov/33792557

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KRAS amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Mutations in RAS occur in 30–50% of metastatic colorectal carcinomas (mCRCs) and correlate with resistance to anti-EGFR therapy. Consequently, mCRC biomarker guidelines state RAS mutational testing should be performed when considering EGFR inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e441715c6adfccfa83963b1a5740cdc4
https://pubmed.ncbi.nlm.nih.gov/32376853

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Benign call rate and molecular test result distribution of ThyroSeq v3

Autor: Pooja Manroa, N. Paul Ohori, Shane O. LeBeau, Marina N. Nikiforova, Yuri E. Nikiforov, Raja R. Seethala, Michael S. Landau, Sally E. Carty, Karen E. Schoedel, Linwah Yip

Publikováno v: Cancer Cytopathology. 127:161-168

Background The benign call rate (BCR) is the percentage of cytomorphologically indeterminate cases with subsequent benign or negative molecular results. For rule-out tests, the BCR is an important parameter because these molecular "negative" cases ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82a28517335faf59b07d9d0c7b8d241
https://doi.org/10.1002/cncy.22088

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Site-specific Differences in Colonic Adenocarcinoma

Autor: Frances N. Akwuole, Reetesh K. Pai, Michael A. Landau, Benjamin Zhu

Publikováno v: American Journal of Surgical Pathology. 42:351-358

Recent literature indicates that adenocarcinomas of the cecum differ with respect to molecular alterations compared with noncecal proximal colon adenocarcinomas and that cecal tumor site may be a prognostically relevant variable. We compared molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f4e5803e7763ea0659702a87b540d1
https://doi.org/10.1097/pas.0000000000001004

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