Zobrazeno 1 - 10
of 561
pro vyhledávání: '"Michael A. Gorman"'
Autor:
Hassina Massudi, Jie-Si Luo, Jessica K. Holien, Satyanarayana Gadde, Sukriti Krishan, Mika Herath, Jessica Koach, Brendan W. Stevenson, Michael A. Gorman, Pooja Venkat, Chelsea Mayoh, Xue-Qun Luo, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Publikováno v:
Cancers, Vol 15, Iss 6, p 1822 (2023)
MYCN is a major oncogenic driver for neuroblastoma tumorigenesis, yet there are no direct MYCN inhibitors. We have previously identified PA2G4 as a direct protein-binding partner of MYCN and drive neuroblastoma tumorigenesis. A small molecule known t
Externí odkaz:
https://doaj.org/article/aad41e837a7e4069b630f937ac983c34
Autor:
Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions. U
Externí odkaz:
https://doaj.org/article/7bf35b5ddc6847bfb07b9a7eda692855
Autor:
Christopher G. Langendorf, Kevin R. W. Ngoei, John W. Scott, Naomi X. Y. Ling, Sam M. A. Issa, Michael A. Gorman, Michael W. Parker, Kei Sakamoto, Jonathan S. Oakhill, Bruce E. Kemp
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
AMPK regulates the metabolism and so drugs that activate AMPK might have potential for the treatment of metabolic disease. Here, the authors report the structure of AMPK bound to an activating compound, revealing two binding sites and indicating that
Externí odkaz:
https://doaj.org/article/750524f5495343399d0ec23522953a11
Autor:
Michael Francis Gorman
Publikováno v:
INFORMS Transactions on Education. 23:173-176
This case integrates three different methodologies over a four-part sequence on a problem that mirrors a real-world, published project. Students apply statistics, integer optimization, and simulation analysis toward solving the job assignment problem
Autor:
Michael F. Gorman
Publikováno v:
INFORMS Transactions on Education. 23:144-148
History: This paper has been accepted for the INFORMS Transactions on Education Special Section on Cases Based on Real-World Projects from the INFORMS Journal on Applied Analytics.
Autor:
Michael F. Gorman
Publikováno v:
INFORMS Transactions on Education. 23:139-143
Louisiana Branch Lines is a struggling Southeast U.S. railroad in just four cities and 12 markets. Their marketing, operations, and finance performance is poor and their departments disjointed. In this customizable, nine-part case, instructors can ch
Autor:
Catherine G. Fitzgerald Dickmann, Alexander F. McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura D. Osellame, Michael A. Gorman, Michael W. Parker, Hui K. Gan, Andrew M. Scott, Uwe Ackermann, Ingrid J. G. Burvenich, Jonathan M. White
Publikováno v:
Chemical Communications. 59:3126-3129
A fluorine-18 labelled probe was developed to target bromodomain and extraterminal (BET) proteins for molecular imaging of cancer with positron emission tomography.
Autor:
Michael F. Gorman
Publikováno v:
INFORMS Transactions on Education. 23:149-151
In the Swirltubs case, students apply expected value decision making to a knapsack problem for appliance repairmen. The case is based on a published research paper on work that was actually implemented for a major appliance manufacturer. The case fea
Autor:
Michael F. Gorman
Publikováno v:
INFORMS Journal on Applied Analytics. 53:2-4
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S1. PA2G4 is a MYCN transactivation target gene. A, Quantification of protein expression using anti-PA2G4 and anti-MYCN antibodies against whole cell protein lysates from BE(2)-C and Kelly cells, following MYCN siRNA knockdown fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60025d7d24b347241cbbcf5c562a70ea
https://doi.org/10.1158/0008-5472.22426183.v1
https://doi.org/10.1158/0008-5472.22426183.v1