Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Michael A. Firer"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Cancer is a leading cause of mortality today. Sooner a cancer is detected, the more effective is the treatment. Histopathological diagnosis continues to be the gold standard worldwide for cancer diagnosis, but the methods used are invasive,
Externí odkaz:
https://doaj.org/article/b81964a671e24d4fab1f3ec71bb89699
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1820 (2024)
Cancer therapy, from malignant tumor inhibition to cellular eradication treatment, remains a challenge, especially regarding reduced side effects and low energy consumption during treatment. Hence, phytochemicals as cytotoxic sensitizers or photosens
Externí odkaz:
https://doaj.org/article/d37dce5d43b44da3a240b4c032e607c0
Autor:
Eleonora Ela Hezkiy, Santosh Kumar, Valid Gahramanov, Julia Yaglom, Arkadi Hesin, Suchita Suryakant Jadhav, Ekaterina Guzev, Shivani Patel, Elena Avinery, Michael A. Firer, Michael Y. Sherman
Publikováno v:
Cells, Vol 11, Iss 22, p 3671 (2022)
Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia
Externí odkaz:
https://doaj.org/article/70675f1f639c4b039c8db444af46edd2
Autor:
Ekaterina Guzev, Suchita Suryakant Jadhav, Eleonora Ela Hezkiy, Michael Y. Sherman, Michael A. Firer, Svetlana Bunimovich-Mendrazitsky
Publikováno v:
Cells, Vol 11, Iss 15, p 2325 (2022)
In recent years, mathematical models have developed into an important tool for cancer research, combining quantitative analysis and natural processes. We have focused on Chronic Lymphocytic Leukemia (CLL), since it is one of the most common adult leu
Externí odkaz:
https://doaj.org/article/7797f6065d634a97a377899707ec1521
Autor:
Olga Furman, Alisa Zaporozhets, Dror Tobi, Andrii Bazylevich, Michael A. Firer, Leonid Patsenker, Gary Gellerman, Bat Chen R. Lubin
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1505 (2022)
The epidermal growth factor–epidermal growth factor receptor (EGF-EGFR) pathway has become the main focus of selective chemotherapeutic intervention. As a result, two classes of EGFR inhibitors have been clinically approved, namely monoclonal antib
Externí odkaz:
https://doaj.org/article/da8b9694f98443a2b2b3462694e6d015
Publikováno v:
Symmetry, Vol 14, Iss 6, p 1269 (2022)
This study presents a framework whereby cancer chemotherapy could be improved through collaboration between mathematicians and experimentalists. Following on from our recently published model, we use A20 murine leukemic cells transfected with monomer
Externí odkaz:
https://doaj.org/article/5772c4ff92034e35a8e803ac1f2f80a0
Autor:
Kalishwaralal Kalimuthu, Bat-Chen Lubin, Andrii Bazylevich, Gary Gellerman, Ofer Shpilberg, Galia Luboshits, Michael A. Firer
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Background Peptide-drug-conjugates (PDCs) are being developed as an effective strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges to their successful application is the relatively low stability of
Externí odkaz:
https://doaj.org/article/769e9a94a2704d54834923808d687bc0
Publikováno v:
Symmetry, Vol 13, Iss 10, p 1760 (2021)
Chlorambucil (Chl), Melphalan (Mel), and Cytarabine (Cyt) are recognized drugs used in the chemotherapy of patients with advanced Chronic Lymphocytic Leukemia (CLL). The optimal treatment schedule and timing of Chl, Mel, and Cyt administration remain
Externí odkaz:
https://doaj.org/article/d1687a2394c340beb5c27cde8085c101
Publikováno v:
Cancers, Vol 13, Iss 16, p 4090 (2021)
Current standard frontline therapy for newly diagnosed patients with multiple myeloma (NDMM) involves induction therapy, autologous stem cell transplantation (ASCT), and maintenance therapy. Major efforts are underway to understand the biological and
Externí odkaz:
https://doaj.org/article/df25984cc0bf443f8b0d4c972b476054
Publikováno v:
Pathology, research and practice. 238
Colorectal cancer (CRC) can been sub-divided, based on the generation of tertiary lymphoid structures (TLS), into CRC with a Crohn's like lymphoid reaction (CLR) representing de novo formation of TLSs or CRC lacking TLSs that show Diffuse Inflammator