Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Michael A. Duffy"'
Autor:
Isobel S. Walker, Saber Dini, Elizabeth H. Aitken, Timon Damelang, Wina Hasang, Agersew Alemu, Anja T. R. Jensen, Janavi S. Rambhatla, D. Herbert Opi, Michael F. Duffy, Eizo Takashima, Visopo Harawa, Takafumi Tsuboi, Julie A. Simpson, Wilson Mandala, Terrie E. Taylor, Karl B. Seydel, Amy W. Chung, Stephen J. Rogerson
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies,
Externí odkaz:
https://doaj.org/article/207469fd56754378a72987ad51f59013
Publikováno v:
Translational Oncology, Vol 46, Iss , Pp 102025- (2024)
New treatments are urgently required for triple-negative breast cancer (TNBC). As TP53 is mutated in approximately 80% of TNBC, it is theoretically an attractive target for new drugs for this disease. Arsenic trioxide (ATO), which is used to treat pr
Externí odkaz:
https://doaj.org/article/75039994030f4ff8baa64d4d87ad5977
Autor:
Shazia Ruybal-Pesántez, Kathryn E. Tiedje, Gerry Tonkin-Hill, Thomas S. Rask, Moses R. Kamya, Bryan Greenhouse, Grant Dorsey, Michael F. Duffy, Karen P. Day
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/db5d7de483b447ef82809d6b57a0932c
Autor:
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann
Publikováno v:
eLife, Vol 12 (2024)
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorp
Externí odkaz:
https://doaj.org/article/ee63f3338efa4b578bd3c5c0608fd5e0
Autor:
Stefaan W. Verbruggen, Joanne Nolan, Michael P. Duffy, Oliver M.T. Pearce, Christopher R. Jacobs, Martin M. Knight
Publikováno v:
Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)
Abstract Bone metastases are a common cause of suffering in breast and prostate cancer patients, however, the interaction between bone cells and cancer cells is poorly understood. Using a series of co‐culture, conditioned media, human cancer sphero
Externí odkaz:
https://doaj.org/article/76aa04d7a7fa4f45a303ab43a8ff8637
Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation
Autor:
Myriam D. Jeninga, Jingyi Tang, Shamista A. Selvarajah, Alexander G. Maier, Michael F. Duffy, Michaela Petter
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-29 (2023)
Abstract Background The protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple morphologically distinct life forms. A key process for transmission of the disease is the developme
Externí odkaz:
https://doaj.org/article/2121ad1a1f8c4a94a6433d804794cc96
Autor:
Suffian Azizan, Shamista A. Selvarajah, Jingyi Tang, Myriam D. Jeninga, Danae Schulz, Kapil Pareek, Tamara Herr, Karen P. Day, Tania F. De Koning-Ward, Michaela Petter, Michael F. Duffy
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThe Plasmodium falciparum alternative histones Pf H2A.Z and Pf H2B.Z are enriched in the same nucleosomes in intergenic euchromatin but depleted from heterochromatin. They occupy most promoters but are only dynamically associated with express
Externí odkaz:
https://doaj.org/article/0360b043dc2143da902026ff0db27662
Autor:
Michael F. Duffy, Gerry Q. Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh H. T. Nguyen, Janavi S. Rambhatla, Malcolm J. McConville, Stephen J. Rogerson, Graham V. Brown, Ric N. Price, Nicholas M. Anstey, Karen P. Day, Anthony T. Papenfuss
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/4568f818a26f4356ab0ac8724eb7bce5
Autor:
Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R. Trenholme, Julie Healer, Alan F. Cowman, Emily M. Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J. Blanch, Matthew W. A. Dixon, Leann Tilley, Michael F. Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, Anthony T. Papenfuss, Louis Schofield, Paul Griffin, Bridget E. Barber, Dean Andrew, Michelle J. Boyle, Fabian de Labastida Rivera, Christian Engwerda, James S. McCarthy
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage vaccine and test its safety, infectivity, and immunogenicity in healthy volunteers. Our approach w
Externí odkaz:
https://doaj.org/article/74cfc9b904474091b17850c1e5910004
Autor:
Jennifer E. Quinn, Myriam D. Jeninga, Katharina Limm, Kapil Pareek, Tina Meißgeier, Anna Bachmann, Michael F. Duffy, Michaela Petter
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and survival of the human malaria parasite Plasmodium (P.) falciparum. Bromodomain proteins contribute to this process by binding to acetylated lysine residues o
Externí odkaz:
https://doaj.org/article/6213dcd7d9aa4c9693b81f422ea0c278