Zobrazeno 1 - 10
of 396
pro vyhledávání: '"Michael A. Cowley"'
Autor:
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101206- (2021)
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more
Externí odkaz:
https://doaj.org/article/214ce1a22d184bb08a8fd34984c1b999
Autor:
Brandon L. Roberts, Baylin J. Bennett, Camdin M. Bennett, Julie M. Carroll, Louise S. Dalbøge, Colin Hall, Wafa Hassouneh, Kristy M. Heppner, Melissa A. Kirigiti, Sarah R. Lindsley, Katherine G. Tennant, Cadence A. True, Andrew Whittle, Anitra C. Wolf, Charles T. Roberts, Jr., Mads Tang-Christensen, Mark W. Sleeman, Michael A. Cowley, Kevin L. Grove, Paul Kievit
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 18-29 (2019)
Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophren
Externí odkaz:
https://doaj.org/article/2fb89f157ba64298a2342ca376aaca21
Autor:
Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mi
Externí odkaz:
https://doaj.org/article/daba42e8bc934c15ab731e4faf7ff42c
Autor:
Tara Jois, Weiyi Chen, Victor Howard, Rebecca Harvey, Kristina Youngs, Claudia Thalmann, Pradip Saha, Lawrence Chan, Michael A. Cowley, Mark W. Sleeman
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1381-1394 (2017)
Objective: Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivi
Externí odkaz:
https://doaj.org/article/00bdc5cfa2834b0d9ec2d1d4654f1d51
Autor:
Garron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew Eramo, Christina A. Mitchell, Zane B. Andrews, Belinda A. Henry, Michael A. Cowley, Tony Tiganis
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2905-2922.e5 (2019)
Summary: The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP) att
Externí odkaz:
https://doaj.org/article/60e76c7095e44457a9a4422b890fabd6
Autor:
Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 346-355.e3 (2019)
Summary: Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/4127cc54a7be4866b89beba18cafd830
Autor:
Pablo J. Enriori, Weiyi Chen, Maria C. Garcia-Rudaz, Bernadette E. Grayson, Anne E. Evans, Sarah M. Comstock, Ursel Gebhardt, Hermann L. Müller, Thomas Reinehr, Belinda A. Henry, Russell D. Brown, Clinton R. Bruce, Stephanie E. Simonds, Sara A. Litwak, Sean L. McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H. Tschöp, Matthew J. Watt, Iain J. Clarke, Christian L. Roth, Kevin L. Grove, Michael A. Cowley
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 807-822 (2016)
Objective: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) p
Externí odkaz:
https://doaj.org/article/6eebea40ad004d3084746b4f5118b1a3
Autor:
Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the original PDF version of this article, affiliation 1, ‘Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD), Neuherberg, Germany’, was incorrectly given
Externí odkaz:
https://doaj.org/article/ae33b6c3d2134fc19b2fa65e3a0a054d
Autor:
Kim Loh, Sheng Zhang, Pablo J. Enriori, Stephanie E. Simonds, Zane B. Andrews, Florian Wiede, Benjamin G. Neel, Atsushi Fukushima, Michael A. Cowley, Tony Tiganis, Alexander Reichenbach, Dana I Briggs, Sandra Galic, Zhong Yin Zhang, Christine Hauser, Kendra K. Bence, Xinmei Zhang, Natalie A. Sims, Barbara B. Kahn
Publikováno v:
Cell Metab
SummaryIn obesity, anorectic responses to leptin are diminished, giving rise to the concept of “leptin resistance.” Increased expression of protein tyrosine phosphatase 1B (PTP1B) has been associated with the attenuation of leptin signaling and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3415f42293a3254252dfb254d01ee0b7
https://europepmc.org/articles/PMC9719734/
https://europepmc.org/articles/PMC9719734/
Autor:
Chen Chen, Zhengxiang Huang, Lyn Gao, Lili Huang, Weihao Wang, Ling Cui, Lixin Guo, Michael A. Cowley
Publikováno v:
Neuroendocrinology. 112:174-185
Background: Dysregulation of metabolic regulatory hormones often occurs during the progress of obesity. Key regulatory hormone insulin-growth hormone (GH) balance has recently been proposed to maintain metabolism profiles. Time-restricted feeding (TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdab9476a5e9ace2c11a86b1f53e1aab
https://doi.org/10.1159/000515960
https://doi.org/10.1159/000515960