Zobrazeno 1 - 10
of 580
pro vyhledávání: '"Michael A. Cowley"'
Autor:
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101206- (2021)
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more
Externí odkaz:
https://doaj.org/article/214ce1a22d184bb08a8fd34984c1b999
Autor:
Brandon L. Roberts, Baylin J. Bennett, Camdin M. Bennett, Julie M. Carroll, Louise S. Dalbøge, Colin Hall, Wafa Hassouneh, Kristy M. Heppner, Melissa A. Kirigiti, Sarah R. Lindsley, Katherine G. Tennant, Cadence A. True, Andrew Whittle, Anitra C. Wolf, Charles T. Roberts, Jr., Mads Tang-Christensen, Mark W. Sleeman, Michael A. Cowley, Kevin L. Grove, Paul Kievit
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 18-29 (2019)
Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophren
Externí odkaz:
https://doaj.org/article/2fb89f157ba64298a2342ca376aaca21
Autor:
Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mi
Externí odkaz:
https://doaj.org/article/daba42e8bc934c15ab731e4faf7ff42c
Autor:
Tara Jois, Weiyi Chen, Victor Howard, Rebecca Harvey, Kristina Youngs, Claudia Thalmann, Pradip Saha, Lawrence Chan, Michael A. Cowley, Mark W. Sleeman
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1381-1394 (2017)
Objective: Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivi
Externí odkaz:
https://doaj.org/article/00bdc5cfa2834b0d9ec2d1d4654f1d51
Autor:
Natalie Jane Michael, Stephanie Elise Simonds, Marco van den Top, Michael Alexander Cowley, David Spanswick
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1103-1112 (2017)
Objective: The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown. As
Externí odkaz:
https://doaj.org/article/d9f88e3372db46ff837bd4d45265dab5
Autor:
Garron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew Eramo, Christina A. Mitchell, Zane B. Andrews, Belinda A. Henry, Michael A. Cowley, Tony Tiganis
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2905-2922.e5 (2019)
Summary: The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP) att
Externí odkaz:
https://doaj.org/article/60e76c7095e44457a9a4422b890fabd6
Autor:
Tomris Mustafa, Qun Li, Lauren E Kelly, Anne Gibbon, Irwin Ryan, Keisha Roffey, Stephanie Simonds, Michael A Cowley, Mark W Sleeman
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214621 (2019)
Experimental non-human primate models of obesity are induced through the introduction of atypically calorically rich diets. Studies in captive-bred macaques show the development of obesity and diabetes with similar complications to humans including e
Externí odkaz:
https://doaj.org/article/65644afc9c3a43dd8d3160011214dc95
Autor:
Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 346-355.e3 (2019)
Summary: Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/4127cc54a7be4866b89beba18cafd830
Autor:
Pablo J. Enriori, Weiyi Chen, Maria C. Garcia-Rudaz, Bernadette E. Grayson, Anne E. Evans, Sarah M. Comstock, Ursel Gebhardt, Hermann L. Müller, Thomas Reinehr, Belinda A. Henry, Russell D. Brown, Clinton R. Bruce, Stephanie E. Simonds, Sara A. Litwak, Sean L. McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H. Tschöp, Matthew J. Watt, Iain J. Clarke, Christian L. Roth, Kevin L. Grove, Michael A. Cowley
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 807-822 (2016)
Objective: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) p
Externí odkaz:
https://doaj.org/article/6eebea40ad004d3084746b4f5118b1a3
Autor:
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis
Publikováno v:
eLife, Vol 7 (2018)
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhib
Externí odkaz:
https://doaj.org/article/fab6ed8d6e114ea6b2ada91531963160