Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Michael A. Colman"'
Autor:
Michael A. Colman, Alan P. Benson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Remodelling of cardiac tissue structure, including intercellular electrical coupling, is a major determinant of the complex and heterogeneous excitation patterns associated with cardiac arrhythmias. Evaluation of the precise mechanisms by wh
Externí odkaz:
https://doaj.org/article/29f483d081134c3291d27dbf556cf9ac
Autor:
Luke A. Howlett, Harley Stevenson‐Cocks, Michael A. Colman, Matthew K. Lancaster, Alan P. Benson
Publikováno v:
Physiological Reports, Vol 11, Iss 14, Pp n/a-n/a (2023)
Abstract This study aimed to simulate ventricular responses to elevations in myocyte pacing and adrenergic stimulation using a novel electrophysiological rat model and investigate ion channel responses underlying action potential (AP) modulations. Pe
Externí odkaz:
https://doaj.org/article/f5a475f73fc043af8fb9a126b6375b73
Autor:
Michael A. Colman, Enrique Alvarez-Lacalle, Blas Echebarria, Daisuke Sato, Henry Sutanto, Jordi Heijman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Regulation of intracellular calcium is a critical component of cardiac electrophysiology and excitation-contraction coupling. The calcium spark, the fundamental element of the intracellular calcium transient, is initiated in specialized nanodomains w
Externí odkaz:
https://doaj.org/article/6db110e315834c2eabb55759d539e7c8
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background: Non-invasive cardiac mapping—also known as Electrocardiographic imaging (ECGi)—is a novel, painless and relatively economic method to map the electrical activation and repolarization patterns of the heart, providing a valuable tool fo
Externí odkaz:
https://doaj.org/article/9e992db8fb9b4e99b9833102faa968e7
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 encoding the α subunit of channels carrying slow delayed rectifier potas
Externí odkaz:
https://doaj.org/article/54610b90a188448399fb326d6efec6f4
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Introduction: The development of improved diagnosis, management, and treatment strategies for human atrial fibrillation (AF) is a significant and important challenge in order to improve quality of life for millions and reduce the substantial social-e
Externí odkaz:
https://doaj.org/article/3ecd27f3040e4070802dbd574f442478
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia. Pharmacological management
Externí odkaz:
https://doaj.org/article/662ef31147c64baf914f32c0648ceafc
Autor:
Xianwei Zhang, Michael A. Colman
Publikováno v:
Biophysical Journal. 122:6-8
Autor:
Michael A Colman, Alan P Benson
Remodelling of cardiac tissue structure, including intercellular electrical coupling, is a major determinant of the complex and heterogeneous excitation patterns associated with cardiac arrhythmias. Evaluation of the precise mechanisms by which local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34aa8d5bd9fbf7616a7ade5283abbee
https://doi.org/10.1101/2022.11.11.516084
https://doi.org/10.1101/2022.11.11.516084
Publikováno v:
Methods. 185:60-81
Computational models of the heart, from cell-level models, through one-, two- and three-dimensional tissue-level simplifications, to biophysically-detailed three-dimensional models of the ventricles, atria or whole heart, allow the simulation of exci