Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Michael A. Brattain"'
Autor:
Michael G. Brattain, Jennie Hauser, Xiao-Qiong Liu, Wang Wang, Karen Kuropatwinski, Junhua Yang, Limin Yang, Jing Wang
Supplementary Figures 1-3 from Transforming Growth Factor β Induces Apoptosis through Repressing the Phosphoinositide 3-Kinase/AKT/Survivin Pathway in Colon Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e9fceba6ad7645cb48613caecceb6f
https://doi.org/10.1158/0008-5472.22374417
https://doi.org/10.1158/0008-5472.22374417
Autor:
Michael G. Brattain, Jennie Hauser, Xiao-Qiong Liu, Wang Wang, Karen Kuropatwinski, Junhua Yang, Limin Yang, Jing Wang
FET cells, derived from an early-stage colon carcinoma, are nontumorigenic in athymic mice. Stable transfection of a dominant-negative transforming growth factor β (TGFβ) type II receptor (DNRII) into FET cells that express autocrine TGFβ shows lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb81a34b7364f1b963201f25c6a70b0
https://doi.org/10.1158/0008-5472.c.6497439
https://doi.org/10.1158/0008-5472.c.6497439
Autor:
Katie L Bailey, Ekta Agarwal, Sanjib Chowdhury, Jiangtao Luo, Michael G Brattain, Jennifer D Black, Jing Wang
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176096 (2017)
In this study, we have uncovered a novel crosstalk between TGFβ and IGF-1R signaling pathways. We show for the first time that expression and activation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFβ/Smad3 signaling. Loss or attenuation
Externí odkaz:
https://doaj.org/article/3f173dc0e49440b4af85f1016da7630d
Autor:
Audrey J. Lazenby, Chandrakanth Are, Lynette M. Smith, Michael G. Brattain, Premila D. Leiphrakpam
Publikováno v:
Journal of Surgical Oncology. 123:1764-1772
OBJECTIVES To evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC). BACKGROUND Stathmin is a phosphoprotein involved in the regulation of microtubule dynamics and integration of intracellular signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5e5aaa6179d9fcec72db4377234745
https://doi.org/10.1002/jso.26464
https://doi.org/10.1002/jso.26464
Autor:
Jennifer D. Black, Chandrakanth Are, Premila D. Leiphrakpam, Sanjib Chowdhury, Lynette M. Smith, Audrey J. Lazenby, Michael G. Brattain, Michelle Mathiesen, Jing Wang
Publikováno v:
J Surg Oncol
Background Na+ /H+ exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic target. The current study evaluated the relationship between NHERF1 expression and clinical outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3544ea53dc685b60b0b1867b580cca3f
https://doi.org/10.1002/jso.25805
https://doi.org/10.1002/jso.25805
Publikováno v:
Cancer research. 79(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2027487648702d7367d43be08092e02d
https://pubmed.ncbi.nlm.nih.gov/15059906
https://pubmed.ncbi.nlm.nih.gov/15059906
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69992 (2013)
Recepteur d'origine nantais (Ron) is overexpressed in a panel of pancreatic cancer cells and tissue samples from pancreatic cancer patients. Ron can be activated by its ligand macrophage stimulating protein (MSP), thereby activating oncogenic signali
Externí odkaz:
https://doaj.org/article/4ab730ffecfa43f3b81918ba30b42c67
Autor:
Sanjib Chowdhury, Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, Jing Wang, Michael G Brattain, Ashwani Rajput
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60299 (2013)
Colorectal cancer (CRC) metastasis is a leading cause of cancer-related deaths in the United States. The molecular mechanisms underlying this complex, multi-step pathway are yet to be completely elucidated. Recent reports have stressed the importance
Externí odkaz:
https://doaj.org/article/33cb8e76738e43758ad18c9863e7ae87
Autor:
Jing Wang, Michael G. Brattain, Premila D. Leiphrakpam, Audrey J. Lazenby, Lynette M. Smith, Chandrakanth Are, Jennifer D. Black
Publikováno v:
J Surg Oncol
Objectives To evaluate the relationship between phosphatase of regenerating liver 3 (PRL3) expression and clinical outcome in colorectal cancer (CRC). Background PRL3, a protein tyrosine phosphatase functions as one of the key regulatory enzymes of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5c8027734ec94d911230f752824f3a
https://pubmed.ncbi.nlm.nih.gov/33179291
https://pubmed.ncbi.nlm.nih.gov/33179291
Publikováno v:
Journal of Biological Chemistry. 293:8242-8254
Aberrant cell survival plays a critical role in cancer progression and metastasis. We have previously shown that ezrin, a cAMP-dependent protein kinase A–anchoring protein (AKAP), is up-regulated in colorectal cancer (CRC) liver metastasis. Phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e21b06301d825a8731e90097c8f75b6
https://doi.org/10.1074/jbc.ra117.001299
https://doi.org/10.1074/jbc.ra117.001299