Zobrazeno 1 - 10 of 612 pro vyhledávání: '"Michael A. Bowers"'
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Akademický článek
Evaluation of classification and regression tree (CART) model in weight loss prediction following head and neck cancer radiation therapy
Autor: Zhi Cheng, MD MPH, Minoru Nakatsugawa, PhD, Chen Hu, PhD, Scott P. Robertson, PhD, Xuan Hui, MD MS, Joseph A. Moore, PhD, Michael R. Bowers, BS, Ana P. Kiess, MD PhD, Brandi R. Page, MD, Laura Burns, BSN, Mariah Muse, BSN, Amanda Choflet, MS RN OCN, Kousuke Sakaue, MS, Shinya Sugiyama, MS, Kazuki Utsunomiya, MS, John W. Wong, PhD, Todd R. McNutt, PhD, Harry Quon, MD MS
Publikováno v: Advances in Radiation Oncology, Vol 3, Iss 3, Pp 346-355 (2018)
Objective: We explore whether a knowledge–discovery approach building a Classification and Regression Tree (CART) prediction model for weight loss (WL) in head and neck cancer (HNC) patients treated with radiation therapy (RT) is feasible. Methods
Externí odkaz: https://doaj.org/article/ddd58f81c04b42b097cb24959f3c7845
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Tachykinin Neuropeptides and Amyloid β (25-35) Assembly: Friend or Foe?
Autor: Xikun Liu, Pritam Ganguly, Yingying Jin, Michael J. Jhatro, Joan-Emma Shea, Steven K. Buratto, Michael T. Bowers
Publikováno v: Journal of the American Chemical Society. 144(32)
Amyloid β (Aβ) protein is responsible for Alzheimer's disease, and one of its important fragments, Aβ(25-35), is found in the brain and has been shown to be neurotoxic. Tachykinin neuropeptides, including Neuromedin K (NK), Kassinin, and Substance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a305ba4845dc79abb3232334dc39a4ad
https://pubmed.ncbi.nlm.nih.gov/35917596
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Terminal Capping of an Amyloidogenic Tau Fragment Modulates Its Fibrillation Propensity
Autor: Joan-Emma Shea, Grace E. Schonfeld, Sarah L. Claud, Shruti Arya, Pritam Ganguly, Andrea Arsiccio, Xikun Liu, Kristi Lazar Cantrell, Benjamin Trapp, Michael T. Bowers
Publikováno v: The Journal of Physical Chemistry B. 124:8772-8783
Aberrant protein folding leading to the formation of characteristic cross-β-sheet-rich amyloid structures is well known for its association with a variety of debilitating human diseases. Often, depending upon amino acid composition, only a small seg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b03319262a57dcddb92357001ebfd25
https://doi.org/10.1021/acs.jpcb.0c05768
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8
Latent Models of Molecular Dynamics Data: Automatic Order Parameter Generation for Peptide Fibrillization
Autor: Joan-Emma Shea, Nathaniel Charest, Michael T. Bowers, Michael Tro
Publikováno v: The Journal of Physical Chemistry B. 124:8012-8022
Variational autoencoders are artificial neural networks with the capability to reduce highly dimensional sets of data to smaller dimensional, latent representations. In this work, these models are applied to molecular dynamics simulations of the self
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85b262c70185fae9053ba1d3ac93db2
https://doi.org/10.1021/acs.jpcb.0c05763
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9
Modulating ALS-Related Amyloidogenic TDP-43307–319 Oligomeric Aggregates with Computationally Derived Therapeutic Molecules
Autor: Nicole M. Marsh, Dezmond Bishop, Michael T. Bowers, Kristi Lazar Cantrell, Veronica Laos, Christian A. Lang, Steven K. Buratto, Ambuj K. Singh
Publikováno v: Biochemistry. 59:499-508
TDP-43 aggregates are a salient feature of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and a variety of other neurodegenerative diseases, including Alzheimer's disease (AD). With an anticipated growth in the most susceptible d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d92cf8b8337f9efddc18c87f8053b09
https://doi.org/10.1021/acs.biochem.9b00905
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Characterizing TDP-43307–319 Oligomeric Assembly: Mechanistic and Structural Implications Involved in the Etiology of Amyotrophic Lateral Sclerosis
Autor: Veronica Laos, Steven K. Buratto, Dezmond Bishop, Thanh D. Do, Kristi Lazar Cantrell, Megan Fetters, Michael T. Bowers, Yingying Jin, Nicole M. Marsh, Brady Quon
Publikováno v: ACS Chemical Neuroscience. 10:4112-4123
Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a salient feature of amyotrophic lateral sclerosis (ALS), a debilitating neurodegenerative disorder affecting over 200 000 people worldwide. The protein undergoes both functional and pathog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31956ade7e618563ba6389b00e4f4e25
https://doi.org/10.1021/acschemneuro.9b00337
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