Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael A. Blanar"'
Autor:
Dezhi Xing, John Lloyd, Karnail S. Atwal, Mei Mann Hsueh, Yolanda Caringal, Ruth R. Wexler, Alexander Kover, Paul Levesque, Ji Jiang, Timothy W. Harper, Mary Lee Conder, Heather Finlay, Michael A. Blanar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1743-1747
Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e51799a21b73f50199fc9a444acca4
https://doi.org/10.1016/j.bmcl.2013.01.064
https://doi.org/10.1016/j.bmcl.2013.01.064
Autor:
Doree F. Sitkoff, Ming Chang, Carolyn A Cuff, Bang-Chi Chen, Cort S. Madsen, Xiaohong Yin, Saleem Ahmad, Evan B. Janovitz, Richard A. Reeves, Thomas Harrity, Lawrence J. Kennedy, Carol S. Ryan, Hossain Monshizadegan, Van Nguyen-Tran, Tong Li, Robert Zahler, Michael A. Blanar, Khehyong Ngu, Philip D. Stein, Rongan Zhang, Sharon N. Bisaha, Christine Huang, Joel C. Barrish, Eileen Bird, Debra Search, Celia D’Arienzo, Mary Giancarli, Robert Setters, Rulin Zhao, Jeffrey A. Robl, Xing Chen, Shaobin Zhuang
Publikováno v:
Journal of Medicinal Chemistry. 51:2722-2733
3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) inhibitors, more commonly known as statins, represent the gold standard in treating hypercholesterolemia. Although statins are regarded as generally safe, they are known to cause myopathy and, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90d3adf6a8d7ca839916f3bce8ae5a0
https://doi.org/10.1021/jm800001n
https://doi.org/10.1021/jm800001n
Autor:
Sabita Sankar, Liwen Huang, Shu-Mang Feng, Eugene H. Cha, Michael A. Blanar, Christopher D. Kontos, Zhiming Yu, Kevin G. Peters, Charles Lin, Robert L. Van Etten, Alfred D. Schroff, Su-Feng Li
Publikováno v:
Journal of Biological Chemistry. 274:38183-38188
Angiogenesis is a tightly controlled process in which signaling by the receptors for vascular endothelial growth factor (VEGF) plays a key role. In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5539f383465f62c11fe5e41f19aa9ea
https://doi.org/10.1074/jbc.274.53.38183
https://doi.org/10.1074/jbc.274.53.38183
Autor:
Christopher D. Kontos, Liwen Huang, Wen-Pin Yang, John D. York, Tobias Meyer, Kevin G. Peters, Michael A. Blanar, Thomas P. Stauffer
Publikováno v:
Molecular and Cellular Biology. 18:4131-4140
Tie2 is an endothelium-specific receptor tyrosine kinase that is required for both normal embryonic vascular development and tumor angiogenesis and is thought to play a role in vascular maintenance. However, the signaling pathways responsible for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dc12679b41dc40d9295af44a506c1b
https://doi.org/10.1128/mcb.18.7.4131
https://doi.org/10.1128/mcb.18.7.4131
Autor:
Mukesh K. Jain, Edgar Haber, Mark A. Perrella, Chung-Ming Hsieh, Mu-En Lee, Michael T. Chin, Michael A. Blanar, Wilson O. Endege, Matthew D. Layne, Shaw-Fang Yet
Publikováno v:
Journal of Biological Chemistry. 273:15654-15660
Phenotypic modulation of vascular smooth muscle cells plays an important role in the pathogenesis of arteriosclerosis. In a screen of proteins expressed in human aortic smooth muscle cells, we identified a novel gene product designated aortic carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb35ff14432b6118bb41bb4b8da2725
https://doi.org/10.1074/jbc.273.25.15654
https://doi.org/10.1074/jbc.273.25.15654
Publikováno v:
Gene. 211:71-78
ATP-sensitive K+ (KATP) channels are implicated in the coupling of metabolic energy to membrane potential, thereby regulating many essential cell functions. Here, we demonstrate that a subunit of human KATP channel, KCNJ8/Kir6.1, is expressed prefere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764bc9f51dac57304751d7d480e9f76f
https://doi.org/10.1016/s0378-1119(98)00086-9
https://doi.org/10.1016/s0378-1119(98)00086-9
Autor:
Michael A. Blanar, Fouad Shalaby, Paul Levesque, Wen-Pin Yang, Wayne A. Little, Mary Lee Conder, Tonya Jenkins-West
Publikováno v:
Circulation. 96:1733-1736
Background Mutations that map to the KvLQT1 gene on human chromosome 11 account for more than 50% of inherited long QT syndrome (LQTS). It has been discovered recently that the KvLQT1 and minK proteins functionally interact to generate a current with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79bfdc31eda2e9a24b2890404c658a2
https://doi.org/10.1161/01.cir.96.6.1733
https://doi.org/10.1161/01.cir.96.6.1733
Autor:
Michael A. Blanar, Wayne A. Little, Fouad Shalaby, Paul C. Levesque, Wen-Pin Yang, Mary Lee Conder
Publikováno v:
Proceedings of the National Academy of Sciences. 94:4017-4021
The clinical features of long QT syndrome result from episodic life-threatening cardiac arrhythmias, specifically the polymorphic ventricular tachycardia torsades de pointes. KVLQT1 has been established as the human chromosome 11-linked gene responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3d54fedd35a433780befb206de4816
https://doi.org/10.1073/pnas.94.8.4017
https://doi.org/10.1073/pnas.94.8.4017
Autor:
Margaret L. Flannery, Eiríkur Steingrímsson, Michael A. Blanar, William J. Rutter, Zena Werb, Nancy A. Jenkins, Neal G. Copeland, James C. Cross
Publikováno v:
Development. 121:2513-2523
Trophoblast cells are the first lineage to form in the mammalian conceptus and mediate the process of implantation. We report the cloning of a basic helix-loop-helix (bHLH) transcription factor gene, Hxt, that is expressed in early trophoblast and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bdae78446493604332a115ac442475
https://doi.org/10.1242/dev.121.8.2513
https://doi.org/10.1242/dev.121.8.2513
Autor:
Huabin Sun, Joseph Prol, Karnail S. Atwal, T.W. Harper, Yolanda Caringal, Michael A. Blanar, Ruth R. Wexler, Jinping Gan, Christine Huang, Wayne Vaccaro, Alexander Kover, Paul Levesque, Heather Finlay, Lin Yan, John Lloyd, John D. Dimarco, Mary Lee Conder, Tram N. Huynh, Bhandaru Rao S, Gauri Bhave
Publikováno v:
Journal of medicinal chemistry. 55(7)
Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of I(Kur) current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ac692afc55a7651f54a83a704a341
https://pubmed.ncbi.nlm.nih.gov/22409629
https://pubmed.ncbi.nlm.nih.gov/22409629