Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael A Trembley"'
Autor:
Maksymilian Prondzynski, Paul Berkson, Michael A. Trembley, Yashasvi Tharani, Kevin Shani, Raul H. Bortolin, Mason E. Sweat, Joshua Mayourian, Dogacan Yucel, Albert M. Cordoves, Beatrice Gabbin, Cuilan Hou, Nnaemeka J. Anyanwu, Farina Nawar, Justin Cotton, Joseph Milosh, David Walker, Yan Zhang, Fujian Lu, Xujie Liu, Kevin Kit Parker, Vassilios J. Bezzerides, William T. Pu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality, inter-batch consistency, cryopreservation and scale remain, reducing experimental reproducibility an
Externí odkaz:
https://doaj.org/article/2c3c411f4998447e802af8965f170ea9
Autor:
Pearl Quijada, Michael A. Trembley, Adwiteeya Misra, Jacquelyn A. Myers, Cameron D. Baker, Marta Pérez-Hernández, Jason R. Myers, Ronald A. Dirkx, Ethan David Cohen, Mario Delmar, John M. Ashton, Eric M. Small
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
It remains unclear how spatial information controls endothelial cell identity and behavior in the developing heart. Here the authors perform single cell RNA sequencing at key developmental timepoints in mice to interrogate cellular contributions to c
Externí odkaz:
https://doaj.org/article/490625a4402947fb92af5dfa14861595
Autor:
Pingzhu Zhou, Yan Zhang, Isha Sethi, Lincai Ye, Michael A. Trembley, Yangpo Cao, Brynn N. Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D. Jardin, Neil Mazumdar, Qing Ma, Aibin He, Bin Zhou, William T. Pu
Publikováno v:
Circulation research. 131(11)
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupancy in the developing heart underlies its lineage s
Autor:
Mason E. Sweat, Yangpo Cao, Xiaoran Zhang, Ozanna Burnicka-Turek, Carlos Perez-Cervantes, Brynn N. Akerberg, Qing Ma, Hiroko Wakimoto, Joshua M. Gorham, Mi Kyoung Song, Michael A. Trembley, Peizhe Wang, Fujian Lu, Matteo Gianeselli, Maksymilian Prondzynski, Raul H. Bortolin, Jonathan G. Seidman, Christine E. Seidman, Ivan P. Moskowitz, William T. Pu
Publikováno v:
bioRxiv
Understanding how the atrial and ventricular chambers of the heart maintain their distinct identity is a prerequisite for treating chamber-specific diseases. Here, we selectively inactivated the transcription factorTbx5in the atrial working myocardiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e019c2713c76df1072f0d0d59e6070
https://europepmc.org/articles/PMC10153240/
https://europepmc.org/articles/PMC10153240/
Publikováno v:
Circ Res
The heart is lined by a single layer of mesothelial cells called the epicardium that provides important cellular contributions for embryonic heart formation. The epicardium harbors a population of progenitor cells that undergo epithelial-to-mesenchym
Autor:
Jason R. Myers, Michael A. Trembley, Adwiteeya Misra, Ronald A. Dirkx, John M. Ashton, Marta Pérez-Hernández, Mario Delmar, Ethan D. Cohen, Eric M. Small, Jacquelyn A. Myers, Pearl Quijada, Cameron D. Baker
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The organization of an integrated coronary vasculature requires the specification of immature endothelial cells (ECs) into arterial and venous fates based on their localization within the heart. It remains unclear how spatial information controls EC
Publikováno v:
Bioscience Reports, Vol 34, Iss 2, p e00099 (2014)
14-3-3 proteins are highly conserved and have been found in all eukaryotic organisms investigated. They are involved in many varied cellular processes, and interact with hundreds of other proteins. Among many other roles in cells, yeast 14-3-3 protei
Externí odkaz:
https://doaj.org/article/f27ed256970a4c238df5ad2974af04a2
Autor:
Nathan J. Sniadecki, Kunhua Song, Michael A. Trembley, Eric M. Small, Peter M. Buttrick, Kevin M. Beussman, Andrea Leonard, Lori A. Walker, C. Y. Chi, Mark Y. Jeong, Walter E. Knight, Yuanbiao Zhao, Ellis Aune, Yingqiong Cao, Matthew R.G. Taylor, Pilar Londono, Hongyan Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 116:556-565
Mutations in lysosomal-associated membrane protein 2 ( LAMP-2 ) gene are associated with Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined mechanisms. Here, we identify the LAMP-2 isoform B (LAMP-2B) as required
Autor:
Guo-Cheng Yuan, Yuxuan Guo, Eric M. Small, Qing Ma, Michael A. Trembley, Alan H. Beggs, Behzad Moghadaszadeh, Emily C Troiano, Blake D. Jardin, Yangpo Cao, Isha Sethi, Neil Mazumdar, William T. Pu
Publikováno v:
Proc Natl Acad Sci U S A
The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that
Autor:
Blake D. Jardin, Emily C Troiano, Behzad Moghadaszadeh, Yuxuan Guo, Isha Sethi, William T. Pu, Michael A. Trembley, Eric M. Small, Guo-Cheng Yuan, Qing Ma, Alan H. Beggs
Cardiomyocyte maturation is essential for robust heart contraction throughout life. The signaling networks governing cardiomyocyte maturation remain poorly defined. Our prior studies established the transcription factor SRF as a key regulator of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b043814854f2a3afbd96a000251dd
https://doi.org/10.1101/824185
https://doi.org/10.1101/824185