Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Michael A Schwarzschild"'
Autor:
Katherine C Hughes, Xiang Gao, Michael A Schwarzschild, Alberto Ascherio, Mario H Flores-Torres, Samantha Molsberry, Jae H Kang
Publikováno v:
BMJ Neurology Open, Vol 3, Iss 1 (2021)
Objective Subtle cognitive deficits can occur during the prodromal phase of Parkinson’s disease (PD), commonly in conjunction with hyposmia. However, little is known about the association between cognitive function and other features suggestive of
Externí odkaz:
https://doaj.org/article/cefe28bffd394e40ab5fa81433889220
Autor:
Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, Sébastien Moniot, Fanny Herisson, Nazifa Abdul Rauf, Hua Wang, Richard B Silverman, Cenk Ayata, Michelle M Maxwell, Clemens Steegborn, Michael A Schwarzschild, Tiago F Outeiro, Aleksey G Kazantsev
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116919 (2015)
Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. In the present study
Externí odkaz:
https://doaj.org/article/6d4507c8725e4994b616076e9bb86115
Autor:
Nikolaus R McFarland, Hemi Dimant, Laura Kibuuka, Darius Ebrahimi-Fakhari, Cody A Desjardins, Karin M Danzer, Michael Danzer, Zhanyun Fan, Michael A Schwarzschild, Warren Hirst, Pamela J McLean
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86048 (2014)
Hsp90 inhibitors such as geldanamycin potently induce Hsp70 and reduce cytotoxicity due to α-synuclein expression, although their use has been limited due to toxicity, brain permeability, and drug design. We recently described the effects of a novel
Externí odkaz:
https://doaj.org/article/c78d459ac5334556a26f1b1a94649c90
Autor:
Sara Cipriani, Cody A Desjardins, Thomas C Burdett, Yuehang Xu, Kui Xu, Michael A Schwarzschild
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37331 (2012)
Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) and with a slower rate of PD progression. In this study we investigat
Externí odkaz:
https://doaj.org/article/9bb4fb14c8b84f4e841afaa3fe2e6353
Autor:
Ning Xia, Victoria Madore, Ali Albalakhi, Sonia Lin, Taylor Stimpson, Yuehang Xu, Michael A. Schwarzschild, Rachit Bakshi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Chronic neuroinflammation is implicated in the pathogenesis of Parkinson’s disease (PD), one of the most common neurodegenerative diseases. Itaconate, an endogenous metabolite derived from the tricarboxylic acid cycle via immune‐responsi
Externí odkaz:
https://doaj.org/article/43c393e7faae4fc184895bc02560ca9c
Autor:
Sabine Schootemeijer, Nienke M. de Vries, Eric A. Macklin, Kit C.B. Roes, Hilde Joosten, Larsson Omberg, Alberto Ascherio, Michael A. Schwarzschild, Bastiaan R. Bloem
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Exercise has various health benefits for people with Parkinson’s disease (PD). However, implementing exercise into daily life and long-term adherence remain challenging. To increase a sustainable engagement with physical activit
Externí odkaz:
https://doaj.org/article/d24b24c9ffe94219a39c40a3949d4aeb
Publikováno v:
Movement Disorders. 38:361-365
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47e2662d702642b5ad34e151e69a0b11
https://doi.org/10.1002/mds.29343
https://doi.org/10.1002/mds.29343
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson’s disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in heal
Externí odkaz:
https://doaj.org/article/918af729e3504fa18eb9de9a96ee6668
Publikováno v:
Neurology. 99:34-41
Despite the sound epidemiologic and basic science rationales underpinning numerous “disease modification” trials in manifest Parkinson disease (PD), none has convincingly demonstrated that a treatment slows progression. Rapidly expanding knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc55f158764cb7e107076d912b055ba
https://doi.org/10.1212/wnl.0000000000200238
https://doi.org/10.1212/wnl.0000000000200238
Autor:
Sheng, Luo, Haotian, Zou, Glenn T, Stebbins, Michael A, Schwarzschild, Eric A, Macklin, James, Chan, David, Oakes, Tanya, Simuni, Christopher G, Goetz
Publikováno v:
Movement Disorders. 37:1904-1914
Longitudinal item response theory (IRT) models previously suggested that the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor examination has two salient domains, tremor and nontremor, that progress in time and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977422dec66200dc9e6a5eeaa7cb2db5
https://doi.org/10.1002/mds.29154
https://doi.org/10.1002/mds.29154