Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Michael A Rudnicki"'
Autor:
Michael Shelton, Morten Ritso, Jun Liu, Daniel O'Neil, Avetik Kocharyan, Michael A Rudnicki, William L Stanford, Ilona S Skerjanc, Alexandre Blais
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222946 (2019)
Human embryonic stem cell (hESC)-derived skeletal muscle progenitors (SMP)-defined as PAX7-expressing cells with myogenic potential-can provide an abundant source of donor material for muscle stem cell therapy. As in vitro myogenesis is decoupled fro
Externí odkaz:
https://doaj.org/article/90fbe9a338d448ffbee45a916485ed6f
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We have recently made the strikingly discovery that upon a muscle injury, Wnt7a is upregulated and secreted from new regenerating myofibers on the surface of exosomes to elicit its myogenerative response distally. Despite recent advances in
Externí odkaz:
https://doaj.org/article/b98878e1ad2e45b9839dc889787c43aa
Autor:
Lauralyn A McIntyre, David Moher, Dean A Fergusson, Katrina J Sullivan, Shirley H J Mei, Manoj Lalu, John Marshall, Malcolm Mcleod, Gilly Griffin, Jeremy Grimshaw, Alexis Turgeon, Marc T Avey, Michael A Rudnicki, Mazen Jazi, Jason Fishman, Duncan J Stewart, Canadian Critical Care Translational Biology Group
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147170 (2016)
The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical condition that is associated with a 30-40% risk of death, and significant long term morbidity for those who survive. Mesenchymal stromal cells (MSC) have emerged as a potential
Externí odkaz:
https://doaj.org/article/8f1eef8c46e247249df355031cf2ada2
Autor:
Weiyi Liu, Pengpeng Bi, Tizhong Shan, Xin Yang, Hang Yin, Yong-Xu Wang, Ning Liu, Michael A Rudnicki, Shihuan Kuang
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003626 (2013)
Prdm16 determines the bidirectional fate switch of skeletal muscle/brown adipose tissue (BAT) and regulates the thermogenic gene program of subcutaneous white adipose tissue (SAT) in mice. Here we show that miR-133a, a microRNA that is expressed in b
Externí odkaz:
https://doaj.org/article/7b6184e9c790424d99ae955a28313ea0
Autor:
Paul M Krzyzanowski, Feodor D Price, Enrique M Muro, Michael A Rudnicki, Miguel A Andrade-Navarro
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20561 (2011)
Many computational methods have been used to predict novel non-coding RNAs (ncRNAs), but none, to our knowledge, have explicitly investigated the impact of integrating existing cDNA-based Expressed Sequence Tag (EST) data that flank structural RNA pr
Externí odkaz:
https://doaj.org/article/66392f451a1846798160ba945f38346e
Publikováno v:
PLoS ONE, Vol 2, Iss 6, p e553 (2007)
Stem cells are characterized by two defining features, the ability to self-renew and to differentiate into highly specialized cell types. The POU homeodomain transcription factor Oct4 (Pou5f1) is an essential mediator of the embryonic stem cell state
Externí odkaz:
https://doaj.org/article/020868549367415fbadaa1a090e5864e
Publikováno v:
PLoS Biology, Vol 2, Iss 5, p E130 (2004)
CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf
Externí odkaz:
https://doaj.org/article/284be07c9d1f4a51914f9d4e6b34c007
Autor:
Caroline E. Brun, Marie-Claude Sincennes, Alexander Y. T. Lin, Derek Hall, William Jarassier, Peter Feige, Fabien Le Grand, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.
Externí odkaz:
https://doaj.org/article/029f9948098341d7a5dbb5349abfd906
Autor:
Kasun Kodippili, Michael A. Rudnicki
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Progressive muscle weakness and degeneration characterize Duchenne muscular dystrophy (DMD), a lethal, x-linked neuromuscular disorder that affects 1 in 5,000 boys. Loss of dystrophin protein leads to recurrent muscle degeneration, progressive fibros
Externí odkaz:
https://doaj.org/article/ecae9cd0dc444a308ce921afeac29cc2
Autor:
Uxia Gurriaran-Rodriguez, David Datzkiw, Leandro Radusky, Marie Esper, Fan Xiao, Hong Ming, Solomon Fisher, Marina J. Rojas, Yves De Repentigny, Rashmi Kothary, Adriana L. Rojas, Luis Serrano, Aitor Hierro, Michael A Rudnicki
Publikováno v:
bioRxiv
Wnt proteins are secreted hydrophobic glycoproteins that act over long distances through poorly understood mechanisms. We discovered that Wnt7a is secreted on extracellular vesicles (EVs) following muscle injury. Structural analysis identified the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffba98bb4c35f49f21df0606b7341575
https://europepmc.org/articles/PMC10312507/
https://europepmc.org/articles/PMC10312507/
