Zobrazeno 1 - 10
of 486
pro vyhledávání: '"Michael A Resnick"'
Autor:
Vasundhara Sharma, Jennifer J Jordan, Yari Ciribilli, Michael A Resnick, Alessandra Bisio, Alberto Inga
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130170 (2015)
The NF-κB transcription factor family plays a central role in innate immunity and inflammation processes and is frequently dysregulated in cancer. We developed an NF-κB functional assay in yeast to investigate the following issues: transactivation
Externí odkaz:
https://doaj.org/article/85ba93ba06574d5898238fe5cd5349d3
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113435 (2014)
Sister chromatid cohesion (SCC), which is established during DNA replication, ensures genome stability. Establishment of SCC is inhibited in G2. However, this inhibition is relived and SCC is established as a response to DNA damage, a process known a
Externí odkaz:
https://doaj.org/article/e50459805ee74989b1293c60e22f9a6f
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003420 (2013)
Resection is an early step in homology-directed recombinational repair (HDRR) of DNA double-strand breaks (DSBs). Resection enables strand invasion as well as reannealing following DNA synthesis across a DSB to assure efficient HDRR. While resection
Externí odkaz:
https://doaj.org/article/110671a0bde14ca480040f1dac40a224
Autor:
Kin Chan, Joan F Sterling, Steven A Roberts, Ashok S Bhagwat, Michael A Resnick, Dmitry A Gordenin
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003149 (2012)
Chromosomal DNA must be in single-strand form for important transactions such as replication, transcription, and recombination to occur. The single-strand DNA (ssDNA) is more prone to damage than double-strand DNA (dsDNA), due to greater exposure of
Externí odkaz:
https://doaj.org/article/349ee224efa9469fbb7792d777b2c133
Autor:
Daniel Menendez, Maria Shatz, Kathleen Azzam, Stavros Garantziotis, Michael B Fessler, Michael A Resnick
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001360 (2011)
In recent years the functions that the p53 tumor suppressor plays in human biology have been greatly extended beyond "guardian of the genome." Our studies of promoter response element sequences targeted by the p53 master regulatory transcription fact
Externí odkaz:
https://doaj.org/article/1c851161da124fd6ab494edb49d4b45a
Autor:
Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20643 (2011)
BackgroundThe p53 tumor suppressor, which is altered in most cancers, is a sequence-specific transcription factor that is able to modulate the expression of many target genes and influence a variety of cellular pathways. Inactivation of the p53 pathw
Externí odkaz:
https://doaj.org/article/2b8a025dfb6a4609b60f93c77cb8b8e6
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001006 (2010)
Double-strand break (DSB) repair through homologous recombination (HR) is an evolutionarily conserved process that is generally error-free. The risk to genome stability posed by nonallelic recombination or loss-of-heterozygosity could be reduced by c
Externí odkaz:
https://doaj.org/article/31710bb9f3f74797a0a16e5483d2ae50
Autor:
Yari Ciribilli, Virginia Andreotti, Daniel Menendez, Jan-Stephan Langen, Gilbert Schoenfelder, Michael A Resnick, Alberto Inga
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10236 (2010)
BackgroundRecently, we established that a C>T single nucleotide polymorphism (SNP) in the promoter of the VEGF receptor FLT1 gene generates a (1/2) site p53 response element (RE-T) that results in p53 responsiveness of the promoter. The transcription
Externí odkaz:
https://doaj.org/article/df11313559c046e288d78100b7f01f31
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000656 (2009)
Resection of DNA double-strand break (DSB) ends is generally considered a critical determinant in pathways of DSB repair and genome stability. Unlike for enzymatically induced site-specific DSBs, little is known about processing of random "dirty-ende
Externí odkaz:
https://doaj.org/article/456e7452b8874470b01a8e61f3d54a07
Autor:
Maher A Noureddine, Daniel Menendez, Michelle R Campbell, Omari J Bandele, Monica M Horvath, Xuting Wang, Gary S Pittman, Brian N Chorley, Michael A Resnick, Douglas A Bell
Publikováno v:
PLoS Genetics, Vol 5, Iss 5, p e1000462 (2009)
The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative f
Externí odkaz:
https://doaj.org/article/c25bbce90e3945b88637a8ae0d552b94