Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Michael A McDannald"'
Autor:
Amanda Chu, Nicholas T Gordon, Aleah M DuBois, Christa B Michel, Katherine E Hanrahan, David C Williams, Stefano Anzellotti, Michael A McDannald
Publikováno v:
eLife, Vol 13 (2024)
Pavlovian fear conditioning has been extensively used to study the behavioral and neural basis of defensive systems. In a typical procedure, a cue is paired with foot shock, and subsequent cue presentation elicits freezing, a behavior theoretically l
Externí odkaz:
https://doaj.org/article/14db4ee757e44138bdb910e6395b4e14
Publikováno v:
eLife, Vol 8 (2019)
The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue – the presumed neural substrate for fear out
Externí odkaz:
https://doaj.org/article/2506ec4824f04ce08c71bd02cbbed566
Autor:
Kristina M Wright, Michael A McDannald
Publikováno v:
eLife, Vol 8 (2019)
Faced with potential harm, individuals must estimate the probability of threat and initiate an appropriate fear response. In the prevailing view, threat probability estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fe
Externí odkaz:
https://doaj.org/article/5c791c96c609470faa4b159a1f97392f
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198043 (2018)
Anxiety disorders and alcohol use disorder are highly comorbid, yet identifying neural dysfunction driving comorbidity has been challenging. Lateral orbitofrontal cortex (lOFC) dysfunction has been independently observed in each disorder. Here we tes
Externí odkaz:
https://doaj.org/article/3a6585576fb549459c4dc11031385723
Autor:
Nina Lopatina, Michael A McDannald, Clay V Styer, Brian F Sadacca, Joseph F Cheer, Geoffrey Schoenbaum
Publikováno v:
eLife, Vol 4 (2015)
The lateral orbitofrontal cortex (lOFC) has been described as signaling either outcome expectancies or value. Previously, we used unblocking to show that lOFC neurons respond to a predictive cue signaling a ‘valueless’ change in outcome features
Externí odkaz:
https://doaj.org/article/5ec627051b9c4a00882964b77fc9d0d3
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 9 (2015)
Early life adversity increases anxiety in adult rodents and primates, and increases the risk for developing post-traumatic disorder (PTSD) in humans. We hypothesized that early adversity impairs the use of learning signals – negative, aversive pred
Externí odkaz:
https://doaj.org/article/4194628c9f72444e9ae6bbaca640e4a0
Autor:
Michael A McDannald, Guillem R Esber, Meredyth A Wegener, Heather M Wied, Tzu-Lan Liu, Thomas A Stalnaker, Joshua L Jones, Jason Trageser, Geoffrey Schoenbaum
Publikováno v:
eLife, Vol 3 (2014)
Externí odkaz:
https://doaj.org/article/20c20b2d994649ae86d9bf84fa414369
Autor:
Michael A McDannald, Guillem R Esber, Meredyth A Wegener, Heather M Wied, Tzu-Lan Liu, Thomas A Stalnaker, Joshua L Jones, Jason Trageser, Geoffrey Schoenbaum
Publikováno v:
eLife, Vol 3 (2014)
The orbitofrontal cortex (OFC) has been described as signaling outcome expectancies or value. Evidence for the latter comes from the studies showing that neural signals in the OFC correlate with value across features. Yet features can co-vary with va
Externí odkaz:
https://doaj.org/article/41fa0e0b0603405e92029c347ecc2fc4
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The prevailing view of threat computation is a division of labor in which the forebrain signals threat and the brainstem organizes behavior. Using neuropixels, the authors show that brainstem neurons organize into a functional network to signal threa
Externí odkaz:
https://doaj.org/article/b361a7a1e35740568dabf58508d00298
Publikováno v:
bioRxiv
Defensive responding is adaptive when it approximates current threat, but maladaptive when it exceeds current threat. Here we asked if the substantia nigra, a region consistently implicated in reward, is necessary to show appropriate levels of defens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0197f32d27c256893da2dd8320aff10
https://doi.org/10.1101/2023.02.18.529041
https://doi.org/10.1101/2023.02.18.529041