Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael A Lobritz"'
Autor:
Gilbert Greub, Giuseppe Pantaleo, Oriol Manuel, Urania Dafni, Valérie D'Acremont, Estelle Moulin, Bruno Grandbastien, Thierry Calandra, Sylvain Meylan, Frederic Lamoth, Zoi Tsourti, Michael A Lobritz, Jean Regina, Philippe Bressin, Laurence Senn, Cyril Andre, Craig Fenwick, Antony Croxatto, Isabelle Guilleret, Catherine Lazor-Blanchet, Oliver Peters, Michael Currat, Laurence Posset, Fady Fares, Vassili Soumas, Séverine Bignon, Elisa Corne, Joana Da Silva Quelhas, Allan Dussex, Dominique Ker, Patricia Mosset, Eugénie Prouvost, Kyllian Ruscio, Sandrine Piccon, Fleur Valterio, Emilie Allain, Charles Guay, Zahra Hezari, Yoann Levet, Marie-Agnès Prevost, Adeline Rognon, Homa Salehi-Gysel, Cécile Starck, Aurélie Tornier, Sara Torres da Fonseca, Aline Udriot
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
Objective To assess the SARS-CoV-2 transmission in healthcare workers (HCWs) using seroprevalence as a surrogate marker of infection in our tertiary care centre according to exposure.Design Seroprevalence cross-sectional study.Setting Single centre a
Externí odkaz:
https://doaj.org/article/fa8971fe6ea54cdd9d307c0e23b1cde2
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30176 (2012)
Latently infected cells form the major obstacle to HIV eradication. Studies of HIV latency have been generally hindered by the lack of a robust and rapidly deployable cell model that involves primary human CD4 T lymphocytes. Latently infected cell li
Externí odkaz:
https://doaj.org/article/f0afb0e1f4054d29815c64b79e422362
Autor:
Matthew S Lalonde, Michael A Lobritz, Annette Ratcliff, Mastooreh Chamanian, Zafiria Athanassiou, Mudit Tyagi, Julian Wong, John A Robinson, Jonathan Karn, Gabriele Varani, Eric J Arts
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002038 (2011)
The RNA response element TAR plays a critical role in HIV replication by providing a binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided approach, we have developed a series of conformationally-constrain
Externí odkaz:
https://doaj.org/article/1b6d4982cad948f5a2fd49a62fb91634
Autor:
Ryan M Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W Krizan, Awet Abraha, Denis M Tebit, Hong Zhao, Santiago Avila, Michael A Lobritz, M Juliana McElrath, Sylvie Le Gall, James I Mullins, Eric J Arts
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000365 (2009)
Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fi
Externí odkaz:
https://doaj.org/article/73d3c53637944733899bd6ed54aaad98
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
Autor:
Kara G Lassen, Michael A Lobritz, Justin R Bailey, Samantha Johnston, Sandra Nguyen, Benhur Lee, Tom Chou, Robert F Siliciano, Martin Markowitz, Eric J Arts
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000377 (2009)
Elite suppressors (ES) are a rare subset of HIV-1-infected individuals who are able to maintain HIV-1 viral loads below the limit of detection by ultra-sensitive clinical assays in the absence of antiretroviral therapy. Mechanism(s) responsible for t
Externí odkaz:
https://doaj.org/article/1affd88ff9fc4fe891148a2ef9556909
Publikováno v:
Cell Metabolism
Summary Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab76f96a90f68e3354db4c9aa60d8ac
https://doi.org/10.1016/j.cmet.2019.06.009
https://doi.org/10.1016/j.cmet.2019.06.009
Autor:
Daniel J. Stieh, Adam Meadows, Yong Gao, Jamie F.S. Mann, Katja Klein, Jeffrey A. Bailey, Immaculate Nankya, Ann M. Carias, Hannah Cheeseman, Thomas J. Hope, Michael A. Lobritz, Gabrielle Nickel, Nicholas J. Hathaway, Annette N. Ratcliff, Eric J. Arts, Robin J. Shattock
Publikováno v:
Journal of Virology
During heterosexual HIV-1 transmission, a genetic bottleneck occurs in the newly infected individual as the virus passes from the mucosa, leading to systemic infection with a single transmitted HIV-1 clone in the recipient. This bottleneck in the rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9f279db2fb305d64da00970ed6862a
https://pubmed.ncbi.nlm.nih.gov/33177204
https://pubmed.ncbi.nlm.nih.gov/33177204
Autor:
Michael A. Lobritz, Ian W. Andrews, Dana Braff, Caroline B.M. Porter, Arnaud Gutierrez, Yoshikazu Furuta, Louis B.G. Cortes, Thomas Ferrante, Sarah C. Bening, Felix Wong, Charley Gruber, Christopher W. Bakerlee, Guillaume Lambert, Graham C. Walker, Daniel J. Dwyer, James J. Collins
Publikováno v:
Cell Chem Biol
β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It was recently shown that β-lactam treatment initializes a futile cycle of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c6daa0525072bdf5594222864b8102
https://doi.org/10.1016/j.chembiol.2021.12.010
https://doi.org/10.1016/j.chembiol.2021.12.010
Autor:
Saloni R. Jain, Michael A. Lobritz, Arnaud Gutierrez, Meagan Hamblin, James J. Collins, Prerna Bhargava
Publikováno v:
Elsevier
Physiologic and environmental factors can modulate antibiotic activity and thus pose a significant challenge to antibiotic treatment. The quinolone class of antibiotics, which targets bacterial topoisomerases, fails to kill bacteria that have grown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dda8da9c502bed2877ddd199c88e8c
https://pubmed.ncbi.nlm.nih.gov/29272702
https://pubmed.ncbi.nlm.nih.gov/29272702
Publikováno v:
Cell Host & Microbe. 13:632-642
Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6cc8ca7b4b5c7cd92bc2282c1e276b
https://doi.org/10.1016/j.chom.2013.05.009
https://doi.org/10.1016/j.chom.2013.05.009