Zobrazeno 1 - 10
of 1 167
pro vyhledávání: '"Michael A Kennedy"'
Autor:
Manoj Lalu, Joshua Montroy, Rebecca C Auer, Donald Bastin, Michael A Kennedy, Sarwat T Khan, Nicole Forbes, Natasha Kekre
Publikováno v:
BMJ Open, Vol 10, Iss 6 (2020)
Introduction Autologous cancer cell vaccines are promising personalised immunotherapeutic options for solid and haematological malignancies that uses the patient’s own cells to arm an immune response. Evidence suggests that among patients receiving
Externí odkaz:
https://doaj.org/article/47ab907d3a2649479d19401ec6b81784
Autor:
Shenyuan Xu, Luay U Ahmed, Michael Robert Stuckert, Kristen Rose McGinnis, Yang Liu, Ming Tan, Pengwei Huang, Weiming Zhong, Dandan Zhao, Xi Jiang, Michael A Kennedy
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008386 (2020)
Initial cell attachment of rotavirus (RV) to specific cell surface glycan receptors, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4. Recently, human histo-blood group antigens (HBGAs) have b
Externí odkaz:
https://doaj.org/article/15f9cbaf94b54e5eb343b6946271037a
Autor:
Faizule Hassan, Sarah L Lossie, Ellen P Kasik, Audrey M Channon, Shuisong Ni, Michael A Kennedy
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192882 (2018)
The HGMA1 architectural transcription factor is highly overexpressed in many human cancers. Because HMGA1 is a hub for regulation of many oncogenes, its overexpression in cancer plays a central role in cancer progression and therefore HMGA1 is gainin
Externí odkaz:
https://doaj.org/article/80f879c77862451cb4b6f702720e0bdb
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200658 (2018)
Pancreatic cancer is the third leading cause of cancer deaths in the United States with more than 53,000 expected to be diagnosed with the disease in 2018. The median survival time after diagnosis is four to six months. The poor survival statistics a
Externí odkaz:
https://doaj.org/article/dfd6affebdec44d3b23e1db87dde52e3
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006707 (2017)
Recognition of specific cell surface glycans, mediated by the VP8* domain of the spike protein VP4, is the essential first step in rotavirus (RV) infection. Due to lack of direct structural information of virus-ligand interactions, the molecular basi
Externí odkaz:
https://doaj.org/article/96ba24369bee48edbbe91c9f45cad4d2
Autor:
Daniel Elnatan, Miguel Betegon, Yanxin Liu, Theresa Ramelot, Michael A Kennedy, David A Agard
Publikováno v:
eLife, Vol 6 (2017)
Hsp90 is a homodimeric ATP-dependent molecular chaperone that remodels its substrate ‘client’ proteins, facilitating their folding and activating them for biological function. Despite decades of research, the mechanism connecting ATP hydrolysis a
Externí odkaz:
https://doaj.org/article/dec2959eea6d4b2abe575a0f8f110a03
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187552 (2017)
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading forms of cancer related deaths in the United States. With limited treatment options and unreliable diagnostic methods, long-term survival rates following a diagnosis of pancreatic cancer r
Externí odkaz:
https://doaj.org/article/3843ac6ec07f460188fecf56d2b3de6d
Autor:
Carmen M Wong, Kathy L Poulin, Grace Tong, Carin Christou, Michael A Kennedy, Theresa Falls, John C Bell, Robin J Parks
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151516 (2016)
Adenoviruses (Ads) are used in numerous preclinical and clinical studies for delivery of anti-cancer therapeutic genes. Unfortunately, Ad has a poor ability to distribute throughout a tumor mass after intratumoral injection, and infects cells primari
Externí odkaz:
https://doaj.org/article/825e776ffce4444e9cbb53baa38f6026
Autor:
Lynda M. McSorley, Mehala Tharmabala, Fathiya Al Rahbi, Fergus Keane, Denis Evoy, James G. Geraghty, Jane Rothwell, Damian P. McCartan, Megan Greally, Miriam O’Connor, Deirdre O’Mahony, Maccon Keane, Michael John Kennedy, Seamus O’Reilly, Steve J. Millen, John P. Crown, Catherine M. Kelly, Ruth S. Prichard, Cecily M. Quinn, Janice M. Walshe
Publikováno v:
Current Oncology, Vol 31, Iss 3, Pp 1302-1310 (2024)
Background: This study, using real-world data, assesses the impact of RS testing on treatment pathways and the associated economic consequences of such testing. This paper pertains to lobular breast cancer. Methods: A retrospective, observational stu
Externí odkaz:
https://doaj.org/article/c7e991104cdb4851bf2dfdfc09b20e5d
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105675 (2014)
The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin, the shortest of which (osteopontin-c) supports anchorag
Externí odkaz:
https://doaj.org/article/ab0e4daa8faa4a03893c785f0a9da7fc