Zobrazeno 1 - 10
of 675
pro vyhledávání: '"Michael A Henderson"'
Autor:
Michael A Henderson
Publikováno v:
Melanoma Management, Vol 6, Iss 3 (2019)
This report surveys the role of topical and intralesional agents in the management of in-transit melanoma. The extent and progression of in-transit disease is highly variable and many patients can have a protracted period of locoregional control. The
Externí odkaz:
https://doaj.org/article/21df1a0feebd4702bf5d80f8fce2fbbc
Autor:
Anne Drougard, Eric H Ma, Vanessa Wegert, Ryan Sheldon, Ilaria Panzeri, Naman Vatsa, Stefanos Apostle, Luca Fagnocchi, Judith Schaf, Klaus Gossens, Josephine Völker, Shengru Pang, Anna Bremser, Erez Dror, Francesca Giacona, Sagar Sagar, Michael X Henderson, Marco Prinz, Russell G Jones, John Andrew Pospisilik
Publikováno v:
eLife, Vol 12 (2024)
Chronic high-fat feeding triggers metabolic dysfunction including obesity, insulin resistance, and diabetes. How high-fat intake first triggers these pathophysiological states remains unknown. Here, we identify an acute microglial metabolic response
Externí odkaz:
https://doaj.org/article/b08ba626a93646c1a6d95a51a856db16
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/d0a1f7879a264df9b8352ca543b913dc
Autor:
Thomas M. Goralski, Lindsay Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel J. Newhouse, Michael X. Henderson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function. Recent work ha
Externí odkaz:
https://doaj.org/article/adda231edd6d4dd9bf1d27ea3cc41c46
Autor:
Haley M. Geertsma, Zoe A. Fisk, Lillian Sauline, Alice Prigent, Kevin Kurgat, Steve M. Callaghan, aSCENT-PD Consortium, Michael X. Henderson, Maxime W. C. Rousseaux
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neurodegeneration. Lewy pathology contains aggregated α-synuclein (αSyn), a protein e
Externí odkaz:
https://doaj.org/article/cd239cac18f9472889efe915a9b430df
Autor:
Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive therapeutic. LRRK2
Externí odkaz:
https://doaj.org/article/1f84f0e37fc14d51a4c531d8dca9e20e
Autor:
Cheryl E. G. Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G. Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M. Van Deerlin, John Q. Trojanowski, Virginia M. Y. Lee, Matthew E. Kennedy, Matthew J. Fell, Michael X. Henderson
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rar
Externí odkaz:
https://doaj.org/article/ffdac8823595475f8729dc4c771b2777
Autor:
Imran Nasim, Michael E. Henderson
Publikováno v:
Mathematics, Vol 12, Iss 3, p 476 (2024)
Dynamical systems are ubiquitous in the physical world and are often well-described by partial differential equations (PDEs). Despite their formally infinite-dimensional solution space, a number of systems have long time dynamics that live on a low-d
Externí odkaz:
https://doaj.org/article/1a6d042e363749f799aba404d9ffcf1e
Autor:
David G. Sibeck, Kyle R. Murphy, F. Scott Porter, Hyunju K. Connor, Brian M. Walsh, Kip D. Kuntz, Eftyhia Zesta, Phil Valek, Charles L. Baker, Jerry Goldstein, Harald Frey, Syau-Yun Hsieh, Pontus C. Brandt, Roman Gomez, Gina A. DiBraccio, Shingo Kameda, Vivek Dwivedi, Michael E. Purucker, Michael Shoemaker, Steven M. Petrinec, Homayon Aryan, Ravindra T. Desai, Michael G. Henderson, Gonzalo Cucho-Padin, W. Douglas Cramer
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 10 (2023)
Much of what we know about the solar wind’s interaction with the Earth’s magnetosphere has been gained from isolated in-situ measurements by single or multiple spacecraft. Based on their observations, we know that reconnection, whether on the day
Externí odkaz:
https://doaj.org/article/71ed68be65b945f1a55f3294d60faa24
Autor:
Lucas Stetzik, Gabriela Mercado, Lindsey Smith, Sonia George, Emmanuel Quansah, Katarzyna Luda, Emily Schulz, Lindsay Meyerdirk, Allison Lindquist, Alexis Bergsma, Russell G. Jones, Lena Brundin, Michael X. Henderson, John Andrew Pospisilik, Patrik Brundin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
There is growing evidence for the key role of microglial functional state in brain pathophysiology. Consequently, there is a need for efficient automated methods to measure the morphological changes distinctive of microglia functional states in resea
Externí odkaz:
https://doaj.org/article/1bddc0e28bb347448bdadb55a853f2cb