Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory.

Autor: Meenakshi Mehrotra, Dzifa Yawa Duose, Rajesh R Singh, Bedia A Barkoh, Jawad Manekia, Michael A Harmon, Keyur P Patel, Mark J Routbort, L Jeffrey Medeiros, Ignacio I Wistuba, Rajyalakshmi Luthra

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0181968 (2017)

Next generation sequencing based tumor tissue genotyping involves complex workflow and a relatively longer turnaround time. Semiconductor based next generation platforms varied from low throughput Ion PGM to high throughput Ion Proton and Ion S5XL se

Externí odkaz: https://doaj.org/article/bb549dfe68a64ba9828eeddd3a89200d

Contemporary trends in PGD incidence, outcomes, and therapies

Autor: Edward Cantu, Joshua M. Diamond, Marisa Cevasco, Yoshi Suzuki, Maria Crespo, Emily Clausen, Laura Dallara, Christian V. Ramon, Michael T. Harmon, Christian Bermudez, Luke Benvenuto, Michaela Anderson, Keith M. Wille, Ann Weinacker, Gundeep S. Dhillon, Jonathan Orens, Pali Shah, Christian Merlo, Vibha Lama, John McDyer, Laurie Snyder, Scott Palmer, Matt Hartwig, Chadi A. Hage, Jonathan Singer, Carolyn Calfee, Jasleen Kukreja, John R. Greenland, Lorraine B. Ware, Russel Localio, Jesse Hsu, Robert Gallop, Jason D. Christie

Publikováno v: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, vol 41, iss 12
J Heart Lung Transplant

BackgroundWe sought to describe trends in extracorporeal membrane oxygenation (ECMO) use, and define the impact on PGD incidence and early mortality in lung transplantation.MethodsPatients were enrolled from August 2011 to June 2018 at 10 transplant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2990cffcfa5bb62efb82ce2d53304f4f
https://escholarship.org/uc/item/5411k42s

Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at risk individuals

Autor: Neelakshi R. Jog, Diane L. Kamen, Gary S. Gilkeson, John B. Harley, Patrick M. Gaffney, Daniel J. Wallace, Michael H. Weisman, Michael T Harmon, David R. Karp, Judith A. James, Jennifer A. Kelly, Kendra A. Young, Joel M. Guthridge, Melissa E. Munroe, Jill M. Norris

Publikováno v: Annals of the rheumatic diseases

ObjectiveSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e678f54ddc284de668d8e7e92e1a794
http://europepmc.org/articles/PMC6692217

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function

Autor: Marina Cella, Mary C. Dinauer, Elaine Kulm, Michelle A. Ritter, Jahnavi Aluri, Alicia Bach, Elise M. Rizzi, Christina Bemrich-Stolz, Maleewan Kitcharoensakkul, Magdalena Walkiewicz, Jack J. Bleesing, Yi Shan Lee, James A. Connelly, Amy M. Scurlock, Laura G. Schuettpelz, Marwan Shinawi, Shirley M. Abraham, Saara Kaviany, V. Koneti Rao, Jonathan D. Powell, Jeffrey J. Bednarski, Peggy L. Kendall, Luana Chiquetto Paracatu, Raphaela Goldbach-Mansky, Christopher D. Putnam, Michael T. Harmon, Adriana Almeida de Jesus, Scott W. Canna, Stacie M. Jones, Morgan Similuk, Matthew M. Demczko, Nermina Saucier, Suk See De Ravin, Michael Joyce, Molly P. Keppel, Megan A. Cooper

Publikováno v: Blood

Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e50b0a6c294707b50db04616dd0efc
https://pubmed.ncbi.nlm.nih.gov/33956066

Non-invasive genotyping of metastatic colorectal cancer using circulating cell free DNA

Autor: Scott Kopetz, Peter Hu, Michael A. Harmon, Dzifa Y. Duose, Ignacio I. Wistuba, Xuemei Shi, Rajyalakshmi Luthra, Meenakshi Mehrotra

Publikováno v: Cancer genetics. 237

Circulating cell-free DNA (ccfDNA) in plasma provides an easily accessible source of circulating tumor DNA (ctDNA) for detecting actionable genomic alterations that can be used to guide colorectal cancer (CRC) treatment and surveillance. The goal of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5378d633d4d3189e14d0b0b9e083e1e
https://pubmed.ncbi.nlm.nih.gov/31447070