Výsledky vyhledávání - "Michael A Freitas"

Akademický článek

Proteomic analysis of the umbilical cord in fetal growth restriction and preeclampsia.

Autor: Matthew S Conrad, Miranda L Gardner, Christine Miguel, Michael A Freitas, Kara M Rood, Marwan Ma'ayeh

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0262041 (2022)

Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE is understudied. This st

Externí odkaz: https://doaj.org/article/283b6b21467d472dbd78e6f48bfd0232

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Akademický článek

Proteomic Signatures of Thymomas.

Autor: Linan Wang, Owen E Branson, Konstantin Shilo, Charles L Hitchcock, Michael A Freitas

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166494 (2016)

Based on the histological features and outcome, the current WHO classification separates thymomas into A, AB, B1, B2 and B3 subtypes. It is hypothesized that the type A thymomas are derived from the thymic medulla while the type B thymomas are derive

Externí odkaz: https://doaj.org/article/3057be92edc74044b094f6ed3fcee197

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Akademický článek

Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins.

Autor: Eric K Johnson, Liwen Zhang, Marvin E Adams, Alistair Phillips, Michael A Freitas, Stanley C Froehner, Kari B Green-Church, Federica Montanaro

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43515 (2012)

Mutations affecting the expression of dystrophin result in progressive loss of skeletal muscle function and cardiomyopathy leading to early mortality. Interestingly, clinical studies revealed no correlation in disease severity or age of onset between

Externí odkaz: https://doaj.org/article/3c5decfd48fe4009b024f1b4aa48a87d

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Akademický článek

The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e10941 (2010)

While deacetylase (DAC) inhibitors show promise for the treatment of B-cell malignancies, those introduced to date are weak inhibitors of class I and II DACs or potent inhibitors of class I DAC only, and have shown suboptimal activity or unacceptable

Externí odkaz: https://doaj.org/article/b8f82372d6bd484e99c19bd6510c448b

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Derivation of the Buffalo Concussion Physical Examination risk of delayed recovery (RDR) score to identify children at risk for persistent postconcussive symptoms

Autor: John J. Leddy, Michael S. Freitas, Mohammad N Haider, Scott R. Darling, Adam Cunningham, Rajiv Jain, Heidi N Suffoletto, Barry Willer

Publikováno v: British Journal of Sports Medicine. 55:1427-1434

ObjectiveThe Buffalo Concussion Physical Examination (BCPE) is a brief, but pertinent physical examination designed for the subacute, outpatient assessment of concussion. The purpose of this study was to perform the BCPE on a larger sample and derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aa8fa4e320ba90c25725273320555b
https://doi.org/10.1136/bjsports-2020-103690

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Posttranslational modifications of the DUX4 protein impact toxic function

Autor: Renatta N. Knox, Jocelyn O. Eidahl, Lindsay Wallace, Sarah Choudury, Afrooz Rashnonejad, Nizar Y. Saad, Michael E. Hoover, Liwen Zhang, Owen E. Branson, Michael A. Freitas, Scott Q. Harper

ObjectiveFacioscapulohumeral muscular dystrophy (FSHD) is caused by abnormal de-repression of the transcription factor DUX4, which is toxic to muscle in vitro and in vivo. While the transcriptional targets of DUX4 are known, the regulation of DUX4 pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::054a7464ca0ed455707f3dc5a3cb508f
https://doi.org/10.1101/2022.07.22.501148

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