Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Michael A Farrar"'
Autor:
Kamran Kaveh, Yutaka Takahashi, Michael A Farrar, Guy Storme, Marcucci Guido, Jamie Piepenburg, Jackson Penning, Jasmine Foo, Kevin Z Leder, Susanta K Hui
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005482 (2017)
Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is characterized by a very poor prognosis and a high likelihood of acquired chemo-resistance. Although tyrosine kinase inhibitor (TKI) therapy has improved clinical outcome, mo
Externí odkaz:
https://doaj.org/article/1cb6e7965526413d84fc296a2d2a4f48
Autor:
Kelly M. Makielski, Aaron L. Sarver, Michael S. Henson, Kathleen M. Stuebner, Antonella Borgatti, Lukkana Suksanpaisan, Caitlin Preusser, Alexandru-Flaviu Tabaran, Ingrid Cornax, M. Gerard O’Sullivan, Andrea Chehadeh, Donna Groschen, Kelly Bergsrud, Sara Pracht, Amber Winter, Lauren J. Mills, Marc D. Schwabenlander, Melissa Wolfe, Michael A. Farrar, Gary R. Cutter, Joseph S. Koopmeiners, Stephen J. Russell, Jaime F. Modiano, Shruthi Naik
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100736- (2023)
Osteosarcoma is a devastating bone cancer that disproportionally afflicts children, adolescents, and young adults. Standard therapy includes surgical tumor resection combined with multiagent chemotherapy, but many patients still suffer from metastati
Externí odkaz:
https://doaj.org/article/f4f7cab98bbe4ae5a0cfe31df10cc42c
Autor:
Pietro Caprioglio, Joel A. Smith, Robert D. J. Oliver, Akash Dasgupta, Saqlain Choudhary, Michael D. Farrar, Alexandra J. Ramadan, Yen-Hung Lin, M. Greyson Christoforo, James M. Ball, Jonas Diekmann, Jarla Thiesbrummel, Karl-Augustin Zaininger, Xinyi Shen, Michael B. Johnston, Dieter Neher, Martin Stolterfoht, Henry J. Snaith
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
A mismatch between quasi-Fermi level splitting and open-circuit voltage is detrimental to wide bandgap perovskite pin solar cells. Here, through theoretical and experimental approaches, the authors optimize n- and p-type interfaces to achieve open-ci
Externí odkaz:
https://doaj.org/article/c5ceec8162f642538069e9e3e7e7af6d
Publikováno v:
Agronomy, Vol 14, Iss 1, p 122 (2024)
Optimal fruit production from many tree crops relies on the transfer of cross-pollen between trees of different cultivars rather than the transfer of self-pollen between trees of the same cultivar. However, many orchards are established with wide blo
Externí odkaz:
https://doaj.org/article/6216ceebaf1a414fb0cf026810a762b0
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells). Since then, a plethora of functionally distinct helper and regulatory CD4 T cell subsets hav
Externí odkaz:
https://doaj.org/article/e216fd75110f4078a7e52558d8fae34f
Autor:
Robin D. Lee, Sarah A. Munro, Todd P. Knutson, Rebecca S. LaRue, Lynn M. Heltemes-Harris, Michael A. Farrar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The characterisation of B cell progenitors could benefit from single cell RNA analysis. Here the authors show distinct transcriptional profiles of B cell progenitors which are dependent upon pre-BCR and these profiles can be related to B cell transfo
Externí odkaz:
https://doaj.org/article/bf459a4d617646fcb5ab701582999f27
Autor:
Nimanie S. Hapuarachchi, Stephen J. Trueman, Wiebke Kämper, Michael B. Farrar, Helen M. Wallace, Joel Nichols, Shahla Hosseini Bai
Publikováno v:
Remote Sensing, Vol 15, Iss 12, p 3100 (2023)
Rapid assessment tools are required for monitoring crop nutrient status and managing fertiliser applications in real time. Hyperspectral imaging has emerged as a promising assessment tool to manage crop nutrition. This study aimed to determine the po
Externí odkaz:
https://doaj.org/article/0ae64f461b9348ae894ca9ddcb61c36c
Autor:
Jason B. Wong, Susannah L. Hewitt, Lynn M. Heltemes-Harris, Malay Mandal, Kristen Johnson, Klaus Rajewsky, Sergei B. Koralov, Marcus R. Clark, Michael A. Farrar, Jane A. Skok
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the
Externí odkaz:
https://doaj.org/article/187b8150da99438da49e30693e5b9441
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The concept that a subset of T cells exists that specifically suppresses immune responses was originally proposed over 50 years ago. It then took the next 30 years to solidify the concept of regulatory T cells (Tregs) into the paradigm we understand
Externí odkaz:
https://doaj.org/article/d6db43e9cf1b40ae8dd460864f0a1865
Autor:
Bing Liu, Oscar C. Salgado, Sangya Singh, Keli L. Hippen, Jason C. Maynard, Alma L. Burlingame, Lauren E. Ball, Bruce R. Blazar, Michael A. Farrar, Kristin A. Hogquist, Hai-Bin Ruan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is ess
Externí odkaz:
https://doaj.org/article/753e12c8c75848d7bf15336570926002